# US 11,440,927 B2 · Hydroxyapatite janus particles

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- Number: US 11,440,927 B2
- Document ID: US11440927B2
- Status: Granted
- Kind: B2
- Application number: 15/823,838
- Filed: 2017-11-28
- Published: 2020-02-27
- Granted: 2022-09-13
- Earliest claimed: 2017-11-28
- Assignees: International Business Machines Corporation
- Applicants: International Business Machines Corporation
- Inventors: Sarah Czaplewski-Campbell; Jason T. Wertz; Brandon M. Kobilka; Eric Campbell
- Web page: https://patentgrep.com/patent/US11440927B2

## CPC

- C07F 9/06: without P—C bonds
- C01B 25/327: {After-treatment}
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)
- C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C}
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

A hydroxyapatite particle having a plurality of functionalities on a surface, a process for forming a hydroxyapatite particle having a plurality of functionalities on a surface, and an article of manufacture including a hydroxyapatite particle having a plurality of functionalities on a surface are disclosed. The hydroxyapatite particle includes a first functionality on a first surface of the hydroxyapatite particle, where the first functionality includes first moieties to bind to polymer constructs, and a second functionality on a second surface of the hydroxyapatite particle. The process for forming the hydroxyapatite particle includes providing one or more hydroxyapatite particles, forming one or more wax particles, functionalizing a first exposed surface of the one or more hydroxyapatite particles, removing the one or more hydroxyapatite particles from the wax core, and functionalizing the second exposed surface of the one or more hydroxyapatite particles.

## Claims

### Claim 1

A hydroxyapatite particle incorporated into a biodegradable polymer construct, the hydroxyapatite particle having a plurality of functionalities on a surface of the hydroxyapatite particle, the hydroxyapatite particle comprising at least:
a first functionality concentrated on a first surface of the hydroxyapatite particle, wherein the first functionality includes first moieties to bind to biodegradable polymer constructs, and wherein the first surface is bound to the biodegradable polymer construct through the first functionality; and
a second functionality concentrated on a second surface of the hydroxyapatite particle, the second surface separate from the first surface, wherein the second functionality includes second moieties.

### Claim 2 (depends on 1)

The hydroxyapatite particle of claim 1, wherein the first moieties to bind to the polymer constructs are selected from a group consisting of azide groups and alkyne groups.

### Claim 3 (depends on 2)

The hydroxyapatite particle of claim 2, wherein the first moieties are azide groups and the polymer constructs are alkyne-functionalized polymer constructs.

### Claim 4 (depends on 2)

The hydroxyapatite particle of claim 2, wherein the first moieties are alkyne groups and the polymer constructs are azide-functionalized polymer constructs.

### Claim 5 (depends on 1)

The hydroxyapatite particle of claim 1, wherein the polymer constructs comprise at least one of polylactic acid, polycaprolactone, polyglycolic acid, and poly(lactic-co-glycolic) acid.

### Claim 6 (depends on 1)

The hydroxyapatite particle of claim 1, wherein the second moieties are bioactive molecules.

### Claim 7 (depends on 6)

The hydroxyapatite particle of claim 6, wherein the bioactive molecules are selected from a group consisting of growth factors, growth factor binding domains derived from proteins, protein domains, peptide sequences, proteins, antibodies, antibodies, cytokines, drugs, deoxyribonucleic acid (DNA), and ribonucleic acid (RNA).

### Claim 8

An article of manufacture comprising a hydroxyapatite particle incorporated into a biodegradable polymer construct, the hydroxyapatite particle having a plurality of functionalities on a surface of the hydroxyapatite particle, the hydroxyapatite particle comprising at least:
a first functionality concentrated on a first surface of the hydroxyapatite particle, wherein the first functionality includes first moieties to bind to biodegradable polymer constructs, and wherein the first surface is bound to the biodegradable polymer construct through the first functionality; and
a second functionality concentrated on a second surface of the hydroxyapatite particle, the second surface separate from the first surface, wherein the second functionality includes second moieties.

### Claim 9 (depends on 8)

The article of manufacture of claim 8, wherein the first moieties to bind to the polymer constructs include at least one of azide groups and alkyne groups.

### Claim 10 (depends on 8)

The article of manufacture of claim 8, wherein the polymer constructs comprise at least one of polylactic acid, polycaprolactone, polyglycolic acid, and poly(lactic-co-glycolic) acid.