# US 11,440,913 B2 · Aminoimidazopyridazines as kinase inhibitors

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- Number: US 11,440,913 B2
- Document ID: US11440913B2
- Status: Granted
- Kind: B2
- Application number: 16/758,892
- Filed: 2018-10-29
- Published: 2020-09-03
- Granted: 2022-09-13
- Earliest claimed: 2017-10-30
- Assignees: Bristol-Myers Squibb Company
- Applicants: Bristol-Myers Squibb Company
- Inventors: Michael E. Mertzman; Carolyn Diane Dzierba; Jason M. Guernon; Amy C. Hart; Guanglin Luo; John E. Macor; William J. Pitts; Jianliang Shi; Steven H. Spergel
- Web page: https://patentgrep.com/patent/US11440913B2

## CPC

- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C07D 487/04: Ortho-condensed systems
- C07D 471/04: Ortho-condensed systems
- C07F 9/6561: containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, (I) are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

## Claims

### Claim 1

A compound having formula (I):
or pharmaceutically acceptable salt thereof,
wherein:
X is CR7 or N;
(i) L is —C(O)NRa— or
and
A is C1-4 alkyl, C1-4 deuteroalkyl, C1-3 alkyl-C3-6 cycloalkyl, C0-3 alkyl-heterocyclyl, C1-4 alkoxy, or C3-6 cycloalkyl-C1-3 alkyl;
wherein the C1-4 alkyl, C1-4 deuteroalkyl, or C1-4 alkoxy is substituted with 0-1 OH substituent;
wherein the alkyl of the C0-3 alkyl-heterocyclyl is substituted with 0-1 OH substituent;
wherein the heterocyclyl of the C0-3 alkyl-heterocyclyl is a 3-6 membered ring containing 1-2 heteroatoms independently selected from the group consisting of N, O, and S; and
wherein the heterocyclyl of the C0-3 alkyl-heterocyclyl is substituted with 0-2 substituents independently selected from the group consisting of halo, C1-3 alkyl, and OH; or
(ii) L is —CH2—; and
A is —NRaC(O)—;
Ra is H, C1-4 alkyl, C1-4 deuteroalkyl, ((phosphonooxy)alkylcarbonyloxy)alkyl, ((amino)alkylcarbonyloxy)alkyl, ((amino)cycloalkylcarbonyloxy)alkyl, ((((phosphonooxy)alkyl)carbonyloxy)alkyl)oxycarbonyl, ((((phosphonooxy)cycloalkyl)carbonyloxy)alkyl)oxycarbonyl, ((((amino)alkyl)carbonyloxy)alkyl)oxycarbonyl, ((((amino)cycloalkyl)carbonyloxy)alkyl)oxycarbonyl, or ((((phosphonooxy)(alkoxy)benzoyl)alkyloxycarbonyl;
R1 is H, halo, C1-3 alkyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 deuteroalkoxy, or C1-3 haloalkoxy;
R2 is H, halo, CN, C1-3 alkyl, C1-3 deuteroalkyl, C1-3 haloalkyl, NH2, C1-3 alkoxy, C1-3 deuteroalkoxy, or C1-3 haloalkoxy;
R3 is phenyl, pyrrolyl, or pyridinyl, wherein the phenyl, pyrrolyl, or pyridinyl is substituted with 0-3 independently selected R3a substituents;
each R3a is independently halo, C1-6 alkyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-3 alkyl-C1-6 alkoxy, C1-3 alkyl-C3-6 cycloalkoxy, CH2-heterocyclyl, C(O)NRcRd, C(O)heterocyclyl, C1-6 alkoxy, hydroxy-C1-6 alkoxy, C1-6 deuteroalkoxy, C1-6 haloalkoxy, C1-3 alkoxy-C3-6 cycloalkyl, C1-3 deuteroalkoxy-C3-6 cycloalkyl, C1-3 haloalkoxy-C3-6 cycloalkyl, OP(O)(OH)2, Oheterocyclyl, OC6-10 aryl, SC6-10 aryl, S(O)2C1-4 alkyl, S(O)2C3-6 cycloalkyl, C3-6 cycloalkyl, C3-6 halocycloalkyl, C3-6 cycloalkoxy, heterocyclyl, or aryl;
wherein each heterocyclyl is independently a 4-6 membered ring containing 1-2 heteroatoms independently selected from the group consisting of N and O; and
wherein each alkyl, cycloalkyl, heterocyclyl, and aryl is independently substituted with 0-2 independently selected Rb substituents; or
two R3a on adjacent atoms join to form —OCH2CH2—, —OCH2CH2CH2—, —OCH2O—, or —OCH2CH2O—;
each Rb is independently halo, C1-3 alkyl, C1-3 haloalkyl, hydroxy-C1-3 alkyl, OH, C1-3 alkoxy, ═O, or C3-6 cycloalkyl;
each Rc is independently H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl;
each Rd is independently H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl; or
each Rc and Rd, taken together with the nitrogen atom to which they are attached, independently forms a 4-6 membered heterocyclyl;
wherein each 4-6 membered heterocyclyl independently contains 0-1 additional heteroatom selected from the group consisting of N, O, and S; and
wherein each 4-6 membered heterocyclyl is independently substituted with 0-4 substituents independently selected from the group consisting of deuterium and halo;
R4 is H, F, Cl, Br, C1-4 alkyl, C1-4 deuteroalkyl, C1-4 haloalkyl, NReRf, C1-4 alkoxy, C1-4 deuteroalkoxy, or cyclopropyl;
Re is H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl;
Rf is H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl; or
Re and Rf, taken together with the nitrogen atom to which they are attached, form a 4-6 membered heterocyclyl, wherein the heterocyclyl is substituted with 0-4 substituents independently selected from the group consisting of deuterium and halo;
(iii) R5 is H, CN, C(O)CHR8NH2, NRgRh, OH, C1-3 alkoxy, OC(O)C1-3 alkyl, or OP(O)(OH)2;
R5a is H or C1-3 alkyl; and
R5b is H or C1-3 alkyl; or
R5a and R5b, taken together with the carbon atom to which they are attached, form a 3-6 membered carbocyclyl or 3-6 membered heterocyclyl;
wherein the 3-6 membered heterocyclyl contains 0-2 heteroatoms independently selected from the group consisting of N, O, and S; and
wherein the 3-6 membered carbocyclyl or 3-6 membered heterocyclyl is substituted with 0-2 substituents independently selected from the group consisting of F, C1-3 alkyl, and C1-3 haloalkyl; or
(iv) R5 is absent; and
R5a and R5b, taken together with the carbon atom to which they are attached, form a 3-6 membered carbocyclyl or 3-6 membered heterocyclyl;
wherein the 3-6 membered heterocyclyl contains 0-2 heteroatoms independently selected from the group consisting of N, O, and S; and
wherein the 3-6 membered carbocyclyl or 3-6 membered heterocyclyl is substituted with 0-1 substituent selected from the group consisting of F and C1-3 alkyl;
Rg is H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl;
Rh is H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl; or
Rg and R1, taken together with the nitrogen atom to which they are attached, form azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl, piperazin-1-yl, or morpholin-4-yl, wherein the azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl, piperazin-1-yl, or morpholin-4-yl is substituted with 0-3 independently selected Ri substituents;
each Ri is independently halo, C1-3 alkyl, or C1-3 haloalkyl;
each Rj is independently halo or OH;
R6 is H or C1-3 alkyl;
R7 is H, halo, CN, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, or C1-3 haloalkoxy;
R8 is H, C1-3 alkyl, or C1-3 alkyl-C1-3 alkoxy; and
n is 0, 1, or 2.

### Claim 2 (depends on 1)

A compound of claim 1, or pharmaceutically acceptable salt thereof, wherein A is C1-4 alkyl or C1-4 deuteroalkyl, wherein the C1-4 alkyl or C1-4 deuteroalkyl is substituted with 0-1 OH substituent.

### Claim 3 (depends on 2)

A compound of claim 2, or pharmaceutically acceptable salt thereof, wherein R3 is phenyl, wherein the phenyl is substituted with 0-3 independently selected R3a substituents.

### Claim 4 (depends on 3)

A compound of claim 3, or pharmaceutically acceptable salt thereof, wherein each R3a is independently halo, C1-6 alkyl, C(O)NRcRd, or C1-6 alkoxy.

### Claim 5 (depends on 3)

A compound of claim 3, or pharmaceutically acceptable salt thereof, wherein:
R1 is H or C1-3 alkyl;
R2 is H, C1-3 alkyl, or C1-3 alkoxy; and
R4 is H, F, Cl, C1-4 alkyl, or C1-4 alkoxy.

### Claim 6 (depends on 5)

A compound of claim 5, or pharmaceutically acceptable salt thereof, wherein A is —CH2—, —CD2-, —CH2CH2—, —CH(CH3)—, —CH(CD3)—, —CH2CH2CH(CH3)—, or —CH2CH2CH(OH)—.

### Claim 7 (depends on 6)

A compound of claim 6, or pharmaceutically acceptable salt thereof, wherein:
X is CR7 or N;
L is —C(O)NH—;
R6 is H; and
R7 is H or halo.

### Claim 8 (depends on 7)

A compound of claim 7, or pharmaceutically acceptable salt thereof, wherein X is CR7.

### Claim 9 (depends on 7)

A compound of claim 7, or pharmaceutically acceptable salt thereof, wherein X is N.

### Claim 10 (depends on 1)

A pharmaceutical composition comprising at least one compound of claim 1, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

### Claim 11 (depends on 1)

A method for inhibiting casein kinase receptor interacting protein kinase 1 (RIPK1) activity in a patient, wherein the method comprises administering to the patient in need thereof a therapeutically effective amount of at least one compound of claim 1, or pharmaceutically acceptable salt thereof.

### Claim 12 (depends on 1)

A method for treating a disease in a patient, wherein the method comprises administering to the patient in need thereof a therapeutically effective amount of at least one compound of claim 1, or pharmaceutically acceptable salt thereof;
wherein treatment of the disease in the patient requires inhibiting casein kinase receptor interacting protein kinase 1 (RIPK1) activity in the patient; and
wherein the disease is selected from the group consisting of Crohn's disease, heart failure, inflammatory bowel disease, psoriasis, rheumatoid arthritis, and ulcerative colitis.

### Claim 13

A compound having formula (I):
or pharmaceutically acceptable salt thereof,
wherein:
X is CR7 or N;
(i) L is —C(O)NRa— or —NRaC(O)—; and
A is C1-4 alkyl, C1-4 deuteroalkyl, C1-3 alkyl-C3-6 cycloalkyl, or C3-6 cycloalkyl-C1-3 alkyl, wherein the C1-4 alkyl or C1-4 deuteroalkyl is substituted with 0-1 OH substituent; or
(ii) L is —CH2—; and
A is —NRaC(O)—;
Ra is H, C1-4 alkyl, or C1-4 deuteroalkyl;
R1 is H, halo, C1-3 alkyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 deuteroalkoxy, or C1-3 haloalkoxy;
R2 is H, halo, CN, C1-3 alkyl, C1-3 deuteroalkyl, C1-3 haloalkyl, NH2, C1-3 alkoxy, C1-3 deuteroalkoxy, or C1-3 haloalkoxy;
R3 is phenyl, pyrrolyl, or pyridinyl, wherein the phenyl, pyrrolyl, or pyridinyl is substituted with 0-3 independently selected R3a substituents;
each R3a is independently halo, C1-6 alkyl, C1-6 deuteroalkyl, C1-6 haloalkyl, C1-3 alkyl-C1-6 alkoxy, C1-3 alkyl-C3-6 cycloalkoxy, CH2-heterocyclyl, C(O)NRcRd, C1-6 alkoxy, hydroxy-C1-6 alkoxy, C1-6 deuteroalkoxy, C1-6 haloalkoxy, C1-3 alkoxy-C3-6 cycloalkyl, C1-3 deuteroalkoxy-C3-6 cycloalkyl, C1-3 haloalkoxy-C3-6 cycloalkyl, Oheterocyclyl, SC6-10 aryl, S(O)2C1-4 alkyl, S(O)2C3-6 cycloalkyl, C3-6 cycloalkyl, C3-6 halocycloalkyl, C3-6 cycloalkoxy, or heterocyclyl;
wherein each heterocyclyl is independently a 4-6 membered ring containing 1-2 heteroatoms independently selected from the group consisting of N and O; and
wherein each alkyl, cycloalkyl, and heterocyclyl is independently substituted with 0-2 independently selected Rb substituents;
each Rb is independently halo, C1-3 alkyl, C1-3 haloalkyl, or =0;
each Rc is independently H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl;
each Rd is independently H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl; or
each Rc and Rd, taken together with the nitrogen atom to which they are attached, independently forms a 4-6 membered heterocyclyl;
wherein each 4-6 membered heterocyclyl independently contains 0-1 additional heteroatom selected from the group consisting of N, O, and S; and
wherein each 4-6 membered heterocyclyl is independently substituted with 0-4 substituents independently selected from the group consisting of deuterium and halo;
R4 is H, F, Cl, Br, C1-4 alkyl, C1-4 deuteroalkyl, C1-4 haloalkyl, NReRf C1-4 alkoxy, C1-4 deuteroalkoxy, or cyclopropyl;
Re is H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl;
Rf is H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl; or
Re and Rf, taken together with the nitrogen atom to which they are attached, form a 4-6 membered heterocyclyl, wherein the heterocyclyl is substituted with 0-4 substituents independently selected from the group consisting of deuterium and halo;
(iii) R5 is H, CN, C(O)CHRgNH2, NRgRh, OH, C1-3 alkoxy, OC(O)C1-3 alkyl, or OP(O)(OH)2;
R5a is H or C1-3 alkyl; and
R5b is H or C1-3 alkyl; or
R5a and R5b, taken together with the carbon atom to which they are attached, form a 3-6 membered carbocyclyl or 3-6 membered heterocyclyl;
wherein the 3-6 membered heterocyclyl contains 0-2 heteroatoms independently selected from the group consisting of N, O, and S; and
wherein the 3-6 membered carbocyclyl or 3-6 membered heterocyclyl is substituted with 0-1 substituent selected from the group consisting of F and C1-3 alkyl; or
(iv) R5 is absent; and
R5a and R5b, taken together with the carbon atom to which they are attached, form a 3-6 membered carbocyclyl or 3-6 membered heterocyclyl;
wherein the 3-6 membered heterocyclyl contains 0-2 heteroatoms independently selected from the group consisting of N, O, and S; and
wherein the 3-6 membered carbocyclyl or 3-6 membered heterocyclyl is substituted with 0-1 substituent selected from the group consisting of F and C1-3 alkyl;
Rg is H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl;
Rh is H, C1-3 alkyl, C1-3 deuteroalkyl, or C3-6 cycloalkyl;
R6 is H or C1-3 alkyl;
R7 is H, halo, CN, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, or C1-3 haloalkoxy; and
R8 is H, C1-3 alkyl, or C1-3 alkyl-C1-3 alkoxy.

### Claim 14

A compound selected from the group consisting of:
N-[(5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridin-3-yl)methyl]-2-fluoro-5-(trifluoromethoxy)benzamide;
N-{[3,5-difluoro-2-(oxan-4-yloxy)phenyl](D2)methyl}-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-methoxypyridine-3-carboxamide;
2-methoxy-5-[2-(2-methoxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}-2-methoxy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}-2-methoxy-5-[2-(2-methylpropanamido)imidazo[1,2-b]pyridazin-6-yl]pyridine-3-carboxamide;
5-{2-acetamido-3-methylimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
5-[2-(2-cyanoacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}-2-methoxypyridine-3-carboxamide;
5-[2-(2-cyano-2,2-dimethylacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methylpyridine-3-carboxamide;
N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxy-5-[2-(2-methylpropanamido)imidazo[1,2-b]pyridazin-6-yl]pyridine-3-carboxamide;
2-chloro-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxy-6-methyl-N-{1-[2-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxy-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3-fluorophenyl]methyl}-5-[2-(2-hydroxy-2-methylpropanamido)imidazo[1,2-b]pyridazin-6-yl]-2-methoxypyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-({2-[(1-hydroxypropan-2-yl)oxy]phenyl}methyl)-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-(trifluoromethyl)pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methyl-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methyl-N-{[2-(propan-2-yloxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopentyloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-[3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
2-fluoro-N-(6-{3-[(3-phenylbutyl)carbamoyl]phenyl}imidazo[1,2-b]pyridazin-2-yl)pyridine-4-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-(3-phenylbutyl)pyridine-3-carboxamide;
5-[2-(2-cyano-2,2-dimethylacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-[(2-{[2-(hydroxymethyl)phenyl]sulfanyl}phenyl)methyl]-2-methylpyridine-3-carboxamide;
5-[2-(2-cyano-2,2-dimethylacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methylpyridine-3-carboxamide;
5-[2-(2-cyano-2,2-dimethylacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
5-[2-(2-cyano-2,2-dimethylacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[5-(cyclopropylmethoxy)-2-fluorophenyl]methyl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-2-(trifluoromethyl)pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,6-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(trifluoromethyl)pyridine-3-carboxamide;
5-[2-(2-cyanoacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-[2-(2-cyanoacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-methoxypyridine-3-carboxamide;
N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-methoxypyridine-3-carboxamide;
N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-5-[2-(2-hydroxy-2-methylpropanamido)imidazo[1,2-b]pyridazin-6-yl]-2-methoxypyridine-3-carboxamide;
5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-N-(2-fluoro-5-methoxybenzyl)-2,6-dimethylnicotinamide;
N-(2-fluoro-5-(trifluoromethoxy)benzyl)-5-(2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl)-2,6-dimethylnicotinamide;
N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(2-fluoro-5-methoxyphenyl)methyl]-2-(D3)methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-(D3)methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-6-(2,2,2-trifluoroethoxy)phenyl]methyl}-2-(D3)methoxypyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-3-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxypyridine-3-carboxamide;
N-({3,5-difluoro-2-[(3R)-oxolan-3-yloxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxypyridine-3-carboxamide;
N-({3,5-difluoro-2-[(3S)-oxolan-3-yloxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxypyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-4-yloxy)phenyl](deutero)methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-(D3)methoxypyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxetan-3-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxypyridine-3-carboxamide;
N-({2-[cyclopropyl(deutero)methoxy]-3,5-difluorophenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxypyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-4-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl}-2-(D3)methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl}-2-(D3)methoxypyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,4-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxy-N-{1-[2-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxypyridine-3-carboxamide;
N-{[5-(cyclopropylmethoxy)-2-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(D3)methoxy-N-{1-[2-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-(D3)methoxypyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-3-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-({3,5-difluoro-2-[(3S)-oxolan-3-yloxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-({3,5-difluoro-2-[(3R)-oxolan-3-yloxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-({3,5-difluoro-2-[(2-methyloxan-4-yl)oxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-[(2-{[(2R,6S)-2,6-dimethyloxan-4-yl]oxy}-3-fluorophenyl)methyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-({2-[(2,6-dimethyloxan-4-yl)oxy]-3,5-difluorophenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethyl-N-{[3-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}pyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-4-yloxy)phenyl](deutero)methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl](2,2,2-deutero)ethyl]-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethyl-N-{[2-(2,2,2-trifluoroethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]methyl}-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethyl-N-{[3-(2,2,2-trifluoroethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethyl-N-{[3-(trifluoromethyl)phenyl](deutero)methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl](deutero)methyl}-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl](deutero)methyl}-2,6-dimethylpyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxetan-3-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-4-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2,6-dimethylpyridine-3-carboxamide;
N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-{[2-(cyclopentylmethoxy)pyridin-3-yl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-{[2-(cyclopentylmethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-{[2-(cyclobutylmethoxy)pyridin-3-yl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethyl-N-{[3-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethyl-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopentylmethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
N-({3,5-difluoro-2-[(3S)-oxolan-3-yloxy]phenyl}methyl)-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2,6-dimethylpyridine-3-carboxamide;
N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2,6-dimethylpyridine-3-carboxamide;
N-{[2-fluoro-5-(trifluoromethyl)phenyl](deutero)methyl}-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2,6-dimethylpyridine-3-carboxamide;
N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2,6-dimethylpyridine-3-carboxamide;
N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2,6-dimethylpyridine-3-carboxamide;
N-({3,5-difluoro-2-[(2-methyloxan-4-yl)oxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(cyclobutylmethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-({3,5-difluoro-2-[(3S)-oxolan-3-yloxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-3-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(2-fluoro-5-methoxyphenyl)methyl]-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{[3-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-6-(2,2,2-trifluoroethoxy)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
N-({2-[(2,6-dimethyloxan-4-yl)oxy]-3,5-difluorophenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-[(1R)-1-[2-(trifluoromethyl)phenyl]ethyl]pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1S)-1-[2-fluoro-5-(trifluoromethyl)phenyl](2,2,2-deutero)ethyl]-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl](2,2,2-deutero)ethyl]-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{[2-(2,2,2-trifluoroethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{[3-(trifluoromethyl)phenyl](deutero)methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl](deutero)methyl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-[(1R)-1-[3-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-({2-[(morpholin-4-yl)methyl]phenyl}methyl)pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-({2-[(propan-2-yloxy)methyl]phenyl}methyl)pyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxetan-3-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[3,5-difluoro-2-(2-methylpropoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{[2-(2-methylpropoxy)phenyl]methyl}pyridine-3-carboxamide;
N-[(2-cyclopropoxy-3,5-difluorophenyl)methyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[4-fluoro-2-(trifluoromethoxy)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
N-({2-[cyclopropyl(deutero)methoxy]-3,5-difluorophenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{1-[2-(cyclopropylmethoxy)-6-fluorophenyl]ethyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{1-[3-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
N-{1-[2-(cyclopropylmethoxy)-6-fluorophenyl]ethyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{1-[3-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{[3-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,6-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-6-(oxan-4-yloxy)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-4-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{1-[2-(cyclopropylmethoxy)-3,5-difluorophenyl]ethyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(1-cyclopropylethoxy)-3,4-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(1-cyclopropylethoxy)-3,4-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{1-[2-(cyclopropylmethoxy)-3,5-difluorophenyl]ethyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(1-cyclopropylethoxy)-3-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(1-cyclopropylethoxy)-3-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[3-(1-cyclopropylethoxy)pyridin-2-yl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{1-[2-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{1-[2-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
N-{[3-(cyclopropylmethoxy)-5-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-[(3,6-difluoro-2-methoxyphenyl)methyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[3-(cyclopropylmethoxy)-4-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-methyl-N-{[3-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(1-cyclopropylethoxy)-3-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl](deutero)methyl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
N-{[2-chloro-5-(trifluoromethyl)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(1-cyclopropylethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[5-(cyclopropylmethoxy)-2-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-4,6-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[4-fluoro-2-(oxan-4-yloxy)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-N-((3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)methyl-d2)-2-methoxynicotinamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
N-{[2-(cyclobutylmethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(cyclopentyloxy)-6-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopropanesulfonyl)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(cyclopentyloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{[2-(1H-pyrrol-1-yl)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[(1S,2S)-2-(4-fluorophenyl)cyclopropyl]methyl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{[2-(morpholin-4-yl)phenyl]methyl}pyridine-3-carboxamide;
N-{[3-(cyclopentyloxy)pyridin-2-yl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(cyclopentylmethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{[2-(propan-2-yloxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopentyloxy)-5-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-({2-[(2,6-dimethyloxan-4-yl)oxy]-3,5-difluorophenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
N-[(2-{[(2R,6S)-2,6-dimethyloxan-4-yl]oxy}-3-fluorophenyl)methyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
N-({3,5-difluoro-2-[(3R)-oxolan-3-yloxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-3-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
N-({3,5-difluoro-2-[(3S)-oxolan-3-yloxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
N-({3,5-difluoro-2-[(2-methyloxan-4-yl)oxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-6-(2,2,2-trifluoroethoxy)phenyl]methyl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
N-({2-[cyclopropyl(deutero)methoxy]-3,5-difluorophenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl](deutero)methyl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,4-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)methoxy-6-methyl-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
N-{[5-(cyclopropylmethoxy)-2-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-(deutero)methoxy-6-methylpyridine-3-carboxamide;
N-[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-methylpyridine-3-carboxamide;
N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-methylpyridine-3-carboxamide;
N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-methylpyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-4-yloxy)phenyl](deutero)methyl}-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-methylpyridine-3-carboxamide;
N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-5-[2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl]-2-methylpyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-3-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-({3,5-difluoro-2-[(3S)-oxolan-3-yloxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-({3,5-difluoro-2-[(2-methyloxan-4-yl)oxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-({2-[(2,6-dimethyloxan-4-yl)oxy]-3,5-difluorophenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-6-(2,2,2-trifluoroethoxy)phenyl]methyl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methyl-N-{[4-(trifluoromethyl)pyridin-2-yl]methyl}pyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-4-yloxy)phenyl](deutero)methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methyl-N-{[2-(2,2,2-trifluoroethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methyl-N-{[3-(2,2,2-trifluoroethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]methyl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1S)-1-[2-fluoro-5-(trifluoromethyl)phenyl](2,2,2-deutero)ethyl]-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl](2,2,2-deutero)ethyl]-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl](deutero)methyl}-2-methylpyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-4-yloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methyl-N-{1-[2-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methyl-N-{1-[2-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl](deutero)methyl}-2-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,4-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-{[2-(cyclobutylmethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-{[5-(cyclopropylmethoxy)-2-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-{[2-(cyclopentylmethoxy)pyridin-3-yl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-{[2-(cyclopentylmethoxy)-5-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-{[2-(cyclobutylmethoxy)-6-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methyl-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methyl-N-{[3-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopentyloxy)-5-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-{[2-(cyclopentyloxy)-6-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methyl-N-{[2-(oxolan-3-yloxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopentyloxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-6-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl](deutero)methyl}-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-6-methyl-N-(3-phenylbutyl)pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-6-methyl-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide;
N-{[5-(cyclopropylmethoxy)-2-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-(3-phenylbutyl)pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-{[2-(cyclopentyloxy)-6-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-{[3-(cyclopentyloxy)pyridin-2-yl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-{[2-(cyclopentyloxy)-5-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-({2-[cyclopropyl(deutero)methoxy]-3,5-difluorophenyl}methyl)-2-methoxy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-{[2-fluoro-5-(trifluoromethoxy)phenyl](deutero)methyl}-2-methoxy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methoxy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-2-methoxy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-4-yloxy)phenyl]methyl}-2-methoxy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
2-methoxy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,4-difluorophenyl]methyl}-2-methoxy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-{[5-(cyclopropylmethoxy)-2-fluorophenyl]methyl}-2-methoxy-5-{2-propanamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
5-{2-acetamido-3-methylimidazo[1,2-b]pyridazin-6-yl}-2-methyl-N-{[3-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamido-3-methylimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-2-methylpyridine-3-carboxamide;
5-{2-acetamido-3-methylimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methylpyridine-3-carboxamide;
5-{2-acetamido-3-methylimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamido-3-methylimidazo[1,2-b]pyridazin-6-yl}-N-{[4-fluoro-3-(trifluoromethoxy)phenyl]methyl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamido-3-methylimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-(3-phenylbutyl)pyridine-3-carboxamide;
5-{2-acetamido-3-methylimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{[3-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamido-3-methylimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-({2-[cyclopropyl(deutero)methoxy]-3,5-difluorophenyl}methyl)-5-{2-acetamido-3-methylimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[5-(cyclopropylmethoxy)-2-fluorophenyl]methyl}-2-methoxy-5-[2-(2-methoxyacetamido)imidazo[1,2-b]pyridazin-6-yl]pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}-2-methoxy-5-[2-(2-methoxyacetamido)imidazo[1,2-b]pyridazin-6-yl]pyridine-3-carboxamide;
N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxy-5-[2-(2-methoxyacetamido)imidazo[1,2-b]pyridazin-6-yl]pyridine-3-carboxamide;
2-methoxy-5-[2-(2-methylpropanamido)imidazo[1,2-b]pyridazin-6-yl]-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,4-difluorophenyl]methyl}-2-methoxy-5-[2-(2-methylpropanamido)imidazo[1,2-b]pyridazin-6-yl]pyridine-3-carboxamide;
N-{[3,5-difluoro-2-(oxan-4-yloxy)phenyl]methyl}-2-methoxy-5-[2-(2-methylpropanamido)imidazo[1,2-b]pyridazin-6-yl]pyridine-3-carboxamide;
2-chloro-N-({2-[cyclopropyl(deutero)methoxy]-3,5-difluorophenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
2-chloro-N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
2-chloro-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
2-chloro-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl}pyridine-3-carboxamide;
2-chloro-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl}pyridine-3-carboxamide;
2-chloro-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
2-chloro-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
2-chloro-N-{[2-(1-cyclobutylethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
2-chloro-N-{[2-chloro-5-(trifluoromethyl)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
2-chloro-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl}-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl}-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl}-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl}-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N,6-dimethyl-N-{[3-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl](deutero)methyl}-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-N,6-dimethyl-N-{[2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-4,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-[(3,6-difluoro-2-methoxyphenyl)methyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,4-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl](deutero)methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclobutylmethoxy)-3-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methyl-N-{1-[3-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methyl-N-{1-[2-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methyl-N-{1-[2-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methyl-N-{1-[3-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclobutylmethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methyl-N-{[2-(trifluoromethoxy)phenyl](deutero)methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[5-(cyclopropylmethoxy)-2-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-4,6-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(1-cyclopentylethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(1-cyclopentylethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methyl-N-{2-[3-(trifluoromethoxy)phenyl]ethyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methyl-N-{[3-(trifluoromethyl)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methyl-N-{[2-(oxolan-3-yloxy)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methyl-N-{[2-(oxolan-3-yloxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(cyclopentylmethoxy)-4,6-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[3-(cyclopropylmethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-({2-[(4,4-difluorocyclohexyl)methoxy]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[3-(cyclopentylmethoxy)pyridin-2-yl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopentylmethoxy)pyridin-3-yl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclobutylmethoxy)pyridin-3-yl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopentylmethoxy)-5-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopentylmethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)-4-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
N-{[2-(cyclopropylmethoxy)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxy-6-methyl-N-{[3-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
2-((6-(5-((2-fluoro-5-(trifluoromethoxy)benzyl)carbamoyl)-2,6-dimethylpyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl)amino)-2-oxoethyl dihydrogen phosphate;
6-chloro-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluoro-2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
6-chloro-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluoro-2-(trifluoromethoxy)phenyl]methyl}pyridine-3-carboxamide;
N-{[2-(3,3-difluoropyrrolidine-1-carbonyl)-5-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
N-{[2-(3,3-difluoropyrrolidine-1-carbonyl)-3,5-difluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methoxypyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-6-(2,2,2-trifluoroethoxy)phenyl]methyl}-2,6-dimethylpyridine-3-carboxamide;
N-{[5-(cyclopropylmethoxy)-2-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-dimethylpyridine-3-carboxamide;
({6-[5-({[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}carbamoyl)-2,6-dimethylpyridin-3-yl]imidazo[1,2-b]pyridazin-2-yl}carbamoyl)methyl acetate;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-ethyl-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-ethyl-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}pyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-N,2-dimethylpyridine-3-carboxamide;
N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]-2-methyl-5-(2-{2-[4-(trifluoromethyl)piperidin-1-yl]acetamido}imidazo[1,2-b]pyridazin-6-yl)pyridine-3-carboxamide;
N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]-2-methyl-5-{2-[2-(4-methylpiperazin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]-2-methyl-5-{2-[2-(pyrrolidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
5-{2-[2-(4,4-difluoropiperidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methylpyridine-3-carboxamide;
5-{2-[2-(3,3-difluoroazetidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methylpyridine-3-carboxamide;
N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methyl-5-{2-[2-(4-methylpiperazin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methyl-5-{2-[2-(morpholin-4-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
5-{2-[2-(dimethylamino)acetamido]imidazo[1,2-b]pyridazin-6-yl}-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methylpyridine-3-carboxamide;
N—((R)-1-(2-fluoro-5-(trifluoromethoxy)phenyl)ethyl)-5-(2-((S)-2-hydroxypropanamido)imidazo[1,2-b]pyridazin-6-yl)-2-methylnicotinamide;
N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methyl-5-{2-[2-(methylamino)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
5-[2-(2-aminoacetamido)imidazo[1,2-b]pyridazin-6-yl]-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methylpyridine-3-carboxamide;
{[6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]carbamoyl}-6-methylpyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl]carbamoyl}methyl acetate;
N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-[2-(4,4-difluoropiperidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-[2-(3,3-difluoroazetidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-2-methyl-5-{2-[2-(morpholin-4-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-2-methyl-5-{2-[2-(morpholin-4-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}pyridine-3-carboxamide;
N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-[2-(dimethylamino)acetamido]imidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[1-(4-fluorophenyl)ethyl]-1H-pyrazol-4-yl}-2-methylpyridine-3-carboxamide;
N-{1-[(4-chlorophenyl)methyl]-1H-imidazol-4-yl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{1-[(4-fluorophenyl)methyl]-1H-imidazol-4-yl}-2-methylpyridine-3-carboxamide;
N-(1-benzyl-1H-imidazol-4-yl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylpyridine-3-carboxamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl}-2-methylpyridine-3-carboxamide;
N-[6-(5-{3-[(4-fluorophenyl)(hydroxy)methyl]piperidine-1-carbonyl}-6-methylpyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl]acetamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-[3-(4-fluorophenyl)-2-hydroxy-2-methylpropyl]-2-methylpyridine-3-carboxamide;
N-[6-(5-{3-[(4-fluorophenyl)methyl]-3-hydroxypiperidine-1-carbonyl}-6-methylpyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl]acetamide;
5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-3-fluoro-N-(2-fluoro-5-(1-methyl-1H-pyrazol-4-yl)benzyl)-2-methylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluoro-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluoro-N-[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-2-methylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluoro-N-{[2-fluoro-3-(trifluoromethoxy)phenyl]methyl}-2-methylbenzamide;
N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-[2-(dimethylamino)acetamido]imidazo[1,2-b]pyridazin-6-yl}-3-fluoro-2-methylbenzamide;
N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-3-fluoro-2-methyl-5-{2-[2-(methylamino)acetamido]imidazo[1,2-b]pyridazin-6-yl}benzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluoro-2-methyl-N-[(2-phenoxyphenyl)methyl]benzamide;
N-{[2-(3,3-difluoropyrrolidine-1-carbonyl)-6-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluoro-2-methylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,3-difluoro-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}benzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,3-difluoro-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]benzamide;
3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4,5-trifluoro-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}benzamide;
3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4,5-trifluoro-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}benzamide;
N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-5-fluorobenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-3-fluoro-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxybenzamide;
3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-5-fluoro-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-4-methylbenzamide;
N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-5-fluoro-4-methylbenzamide;
N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-6-methoxybenzamide;
3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-N-[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]-6-methoxybenzamide;
N-{[2-(3,3-difluoropyrrolidine-1-carbonyl)-5-fluorophenyl]methyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-6-methoxybenzamide;
N-{[2-(cyclopropylmethoxy)phenyl]methyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-6-methoxybenzamide;
(R)-3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluoro-N-(1-(2-fluoro-5-(trifluoromethoxy)phenyl)ethyl-2,2,2-d3)-6-methoxybenzamide;
3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-difluoro-N-[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]benzamide;
(R)-3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2,6-difluoro-N-(1-(2-fluoro-5-(trifluoromethoxy)phenyl)ethyl-2,2,2-d3)benzamide;
N-{[2-(4,4-difluoropiperidine-1-carbonyl)-5-fluorophenyl]methyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,6-difluorobenzamide;
N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4-dimethylbenzamide;
N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4-dimethylbenzamide;
N-{[3-chloro-2-fluoro-5-(trifluoromethyl)phenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4-dimethylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethyl)phenyl]methyl}-2-(trifluoromethyl)benzamide;
2-chloro-N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}benzamide;
2-chloro-N-{[2-(3,3-difluoropyrrolidine-1-carbonyl)-5-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}benzamide;
6-chloro-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]benzamide;
6-chloro-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-N-{[2-fluoro-5-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl}benzamide;
6-chloro-N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluorobenzamide;
6-chloro-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-N-{[4-(trifluoromethoxy)phenyl]methyl}benzamide;
2-chloro-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluoro-N-[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]benzamide;
2-chloro-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-4-methylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methylbenzamide;
(S)—N-(2-fluoro-5-(trifluoromethoxy)benzyl)-5-(2-(2-hydroxypropanamido)imidazo[1,2-b]pyridazin-6-yl)-2-methylbenzamide;
(R)-5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-N-(1-(2-fluoro-5-(trifluoromethoxy)phenyl)ethyl)-2-methylbenzamide;
N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylbenzamide;
N-[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylbenzamide;
N-(1-benzyl-1H-pyrazol-4-yl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-(2-hydroxy-3-phenoxypropyl)-2-methylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[(1S,2S)-2-(4-fluorophenyl)cyclopropyl]methyl}-2-methylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-6-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl}-2-methylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluoro-2-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl}-2-methylbenzamide;
N-{[5-(3,3-difluoroazetidine-1-carbonyl)-2-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylbenzamide;
N-{[2-(3,3-difluoropyrrolidine-1-carbonyl)-4-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylbenzamide;
N-{[5-(3,3-dimethylpyrrolidine-1-carbonyl)-2-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylbenzamide;
N-({3,5-difluoro-2-[(3S)-3-hydroxypyrrolidine-1-carbonyl]phenyl}methyl)-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-methylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[5-fluoro-2-(piperidine-1-carbonyl)phenyl]methyl}-2-methylbenzamide;
N-{[5-(1-cyclopropyl-1H-pyrazol-4-yl)-2-fluorophenyl]methyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-6-methylbenzamide;
N-{[2-(1-cyclopropyl-1H-pyrazol-4-yl)-5-fluorophenyl]methyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-6-methylbenzamide;
N-{[2-(3,3-difluoropyrrolidine-1-carbonyl)-3,4-difluorophenyl]methyl}-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-6-methylbenzamide;
(R)-3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluoro-N-(1-(2-fluoro-5-(trifluoromethoxy)phenyl)ethyl-2,2,2-d3)-6-methylbenzamide;
(R)-3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluoro-N-(1-(2-fluoro-5-(trifluoromethyl)phenyl)ethyl-2,2,2-d3)-6-methylbenzamide;
N-[(3,5-difluoro-2-methoxyphenyl)methyl]-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-6-methylbenzamide;
N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluoro-2-methylbenzamide;
N-{[5-(2,2-dimethylpyrrolidine-1-carbonyl)-2-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluoro-2-methylbenzamide;
5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-N-(2-fluoro-5-(trifluoromethoxy)benzyl)-2-(methoxy-d3)-4-methylbenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxybenzamide;
N-{[2-(2,2-dimethylpyrrolidine-1-carbonyl)-5-fluorophenyl]methyl}-5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluoro-2-methoxybenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluoro-N-[(2-fluoro-6-methoxyphenyl)methyl]-2-methoxybenzamide;
5-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-2-methoxy-4-methylbenzamide;
N-(2-fluoro-5-(trifluoromethoxy)benzyl)-5-(2-(2-hydroxyacetamido)imidazo[1,2-b]pyridazin-6-yl)-2-methoxy-4-methylbenzamide;
3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2,4-difluoro-N-[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]benzamide;
3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-2-fluoro-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}benzamide;
3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-N-(5-(2,2-dimethylazetidine-1-carbonyl)-2-fluorobenzyl)-2-fluorobenzamide;
3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluoro-N-((2-fluoro-5-(trifluoromethoxy)phenyl)methyl-d2)benzamide;
3-{2-[2-(4,4-difluoropiperidin-1-yl)acetamido]imidazo[1,2-b]pyridazin-6-yl}-2-fluoro-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}benzamide;
N-[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]-2-fluoro-3-(2-{2-[4-(trifluoromethyl)piperidin-1-yl]acetamido}imidazo[1,2-b]pyridazin-6-yl)benzamide;
(S)-3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluoro-N-(1-(2-fluoro-5-(trifluoromethoxy)phenyl)ethyl-2,2,2-d3)-4-methylbenzamide;
3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-fluoro-N-((2-fluoro-5-(trifluoromethoxy)phenyl)methyl-d2)-4-methylbenzamide;
4-chloro-3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}benzamide;
3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-4-fluoro-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}benzamide;
3-{2-acetamidoimidazo[1,2-b]pyridazin-6-yl}-N-{[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}-4-methylbenzamide; and
(R)-(((5-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)-2-methylnicotinoyl)(1-(2-fluoro-5-(trifluoromethoxy)phenyl)ethyl)carbamoyl)oxy)methyl 3-methoxy-4-(phosphonooxy)benzoate, or pharmaceutically acceptable salt thereof.