# US 11,440,883 B2 · Heterocyclic compound and use thereof

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- Number: US 11,440,883 B2
- Document ID: US11440883B2
- Status: Granted
- Kind: B2
- Application number: 16/811,426
- Filed: 2020-03-06
- Published: 2020-07-02
- Granted: 2022-09-13
- Earliest claimed: 2017-08-03
- Assignees: Takeda Pharmaceutical Company Limited
- Applicants: Takeda Pharmaceutical Company Limited
- Inventors: Yuichi Kajita; Yuhei Miyanohana; Tatsuki Koike; Kohei Takeuchi; Yoshiteru Ito; Norihito Tokunaga; Takahiro Sugimoto; Tohru Miyazaki; Tsuneo Oda; Yasutaka Hoashi; Yasushi Hattori; Keisuke Imamura
- Web page: https://patentgrep.com/patent/US11440883B2

## CPC

- C07D 211/56: Nitrogen atoms (nitro radicals C07D211/38)
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/26: Psychostimulants, e.g. nicotine, cocaine
- C07D 205/04: having no double bonds between ring members or between ring members and non-ring members
- C07D 207/14: Nitrogen atoms not forming part of a nitro radical
- C07D 211/36: with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D 401/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 401/10: linked by a carbon chain containing aromatic rings
- C07D 401/14: containing three or more hetero rings
- C07D 403/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 405/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 405/10: linked by a carbon chain containing aromatic rings
- C07D 405/12: linked by a chain containing hetero atoms as chain links
- C07D 409/10: linked by a carbon chain containing aromatic rings
- C07D 413/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 417/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 417/14: containing three or more hetero rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, is useful as an agent for the prophylaxis or treatment of narcolepsy.

## Claims

### Claim 1

N-((2S,3S)-1-(2-hydroxy-2-methylpropanoyl)-2-((2,3′,5′-trifluorobiphenyl-3-yl)methyl)pyrrolidin-3-yl)ethanesulfonamide or a salt thereof.