Ketamine derivatives and compositions thereof

A method of treating a psychiatric disease or disorder in a patient comprising administering to a patient in need of such treatment, a therapeutically effective amount of the compound of Formula (1):

• or a pharmaceutically acceptable salt thereof, wherein,
• R1 is selected from hydrogen and C1-3 alkyl;
• and
• R2 is selected from a moiety of Formula (2) and a moiety of Formula (4):
• wherein,
• R3 is selected from hydrogen and C1-6 alkyl;
• R4 is selected from hydrogen and C1-3 alkyl;
• R5 is selected from C1-3 alkyl and —C(═O)—R10, wherein R10 is selected from C1-6 alkyl and —CF3;
• n is 1;
• and
• R9 is C1-3 alkyl,
• wherein the psychiatric disease or disorder is selected from an alcohol use disorder, an anxiety disorder, an obsessive-compulsive disorder, an opioid use disorder, and a posttraumatic stress disorder.