# US 11,440,005 B2 · Device comprising microbeads capable of adjusting pH of sample

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- Number: US 11,440,005 B2
- Document ID: US11440005B2
- Status: Granted
- Kind: B2
- Application number: 16/767,997
- Filed: 2019-08-30
- Published: 2020-11-19
- Granted: 2022-09-13
- Earliest claimed: 2018-08-30
- Assignees: LG Chem, Ltd.
- Applicants: LG Chem, Ltd.
- Inventors: Byung Hyun Park; Byoung Hyoun Kim; Su Youn Han
- Web page: https://patentgrep.com/patent/US11440005B2

## CPC

- B01L 3/502715: {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces}
- B01J 19/00: Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01L 3/50273: {characterised by the means or forces applied to move the fluids}
- B01L 2200/027: for microfluidic devices
- B01L 2200/0647: Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L 2200/16: Reagents, handling or storing thereof
- B01L 2300/0806: Standardised forms, e.g. compact disc [CD] format
- B01L 2300/0864: comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
- B01L 2400/0409: centrifugal forces
- B01L 2400/0478: pistons
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS

## Abstract

The present disclosure relates to a device capable of adjusting the pH of a sample and provides a device comprising microbeads capable of adjusting the pH of a sample to a predetermined value. The device comprises microbeads enabling adjustment to different pH values in each of a plurality of channels, and enables adjustment of the pH of the sample to a plurality of different pH values simultaneously upon injection of the sample.

## Claims

### Claim 1

A device containing microbeads capable of adjusting pH of a sample, comprising:
a channel filled with microbeads;
an inlet for injecting the sample into the channel; and
an outlet for discharging the sample having its pH adjusted in the channel,
wherein the pH of the injected sample is adjusted to the pH of the microbeads in the channel, and
wherein the surface of the microbeads is coated with salt so that the pH of the injected sample can be adjusted to a desired pH in the channel.

### Claim 2 (depends on 1)

The device according to claim 1, further comprising a main injection part for receiving the sample and injecting the sample into the inlet,
wherein the channel is provided in plurality, and each of the channels is provided with the inlet and the outlet,
wherein the microbeads filled in each of the channels are coated to have different pH, and
wherein the sample is branched and introduced into each of the channels from the main injection part.

### Claim 3 (depends on 2)

The device according to claim 2, further comprising a main passage part which connects the main injection part and each of the inlets and has an aliquot structure,
wherein the sample injected into the main injection part is distributed to each of the channels through the main passage part.

### Claim 4 (depends on 1)

The device according to claim 1, further comprising a frit between a region filled with the microbeads in the channel and the outlet,
wherein the sample passed through the microbeads passes through the frit to be discharged to the outlet, and the microbeads are prevented from exiting the outlet.

### Claim 5 (depends on 1)

The device according to claim 1, wherein the channel is provided in plurality, and each of the channels is provided with the inlet and the outlet.

### Claim 6 (depends on 5)

The device according to claim 5, further comprising a main injection part for receiving the sample and injecting the sample into the inlet, and an injection member connected with the main injection part,
wherein the injection member further comprises a piston,
wherein one end of the injection member is connected with the main injection part and the other end of the injection member is provided with the piston, and
wherein the sample is injected into the injection member by pushing the piston, thereby moving the injected sample to each of the channels.

### Claim 7 (depends on 1)

The device according to claim 1, wherein the sample to be injected into the inlet is neutral.

### Claim 8 (depends on 1)

The device according to claim 1, further comprising a main injection part for receiving the sample and injecting the sample into the inlet, wherein
the inlet, the channel and the outlet are provided in plurality respectively and paired with each other, and
each of the plurality of pairs of the inlet, the channel and the outlet is radially disposed on a rotating disk.

### Claim 9 (depends on 8)

The device according to claim 8, further comprising a main passage part connected with the main injection part; and aliquot passage parts extending radially from the main passage part to each of the inlets,
wherein the main injection part comprises an opening through which the sample is injected and a sample reservoir for storing the sample before the injected sample is distributed to each of the aliquot passage parts.

### Claim 10 (depends on 9)

The device according to claim 9, wherein the sample reservoir and the main passage part are coupled in a spiral shape.

### Claim 11 (depends on 10)

The device according to claim 10, wherein the rotating disk has a rotating shaft, and
wherein the main passage part is bent so that one end of the main passage part extends in a direction away from the rotating shaft of the rotating disk.

### Claim 12 (depends on 9)

The device according to claim 9, wherein a vent hole is connected to a flow path between the main passage part and the channel.