# US 11,439,977 B2 · Hybrid material for chromatographic separations comprising a superficially porous core and a surrounding material

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- Number: US 11,439,977 B2
- Document ID: US11439977B2
- Status: Granted
- Kind: B2
- Application number: 15/451,005
- Filed: 2017-03-06
- Published: 2017-06-22
- Granted: 2022-09-13
- Earliest claimed: 2009-06-01
- Assignees: Waters Technologies Corporation
- Applicants: Waters Technologies Corporation
- Inventors: Nicole L. Lawrence; Beatrice W. Muriithi; Kevin D Wyndham
- Web page: https://patentgrep.com/patent/US11439977B2

## CPC

- B01J 20/289: bonded via a spacer
- B01D 15/305: {Hydrophilic interaction chromatography [HILIC]}
- B01D 15/322: {Normal bonded phase}
- B01D 15/325: {Reversed phase}
- B01D 15/34: Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
- B01D 15/3804: {Affinity chromatography}
- B01D 15/40: using supercritical fluid as mobile phase or eluent
- B01J 20/3204: {Inorganic carriers, supports or substrates}
- B01J 20/3257: {the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such}
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)

## Abstract

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The preparation of the inorganic/organic hybrid materials of the invention wherein a surrounding material is condensed on a superficially porous hybrid core material will allow for families of different hybrid packing materials to be prepared from a single core hybrid material. Differences in hydrophobicity, ion-exchange capacity, chemical stability, surface charge or silanol activity of the surrounding material may be used for unique chromatographic separations of small molecules, carbohydrates, antibodies, whole proteins, peptides, and/or DNA.

## Claims

### Claim 1

An inorganic/organic hybrid material comprising an inorganic/organic hybrid surrounding material and a superficially porous core, wherein the inorganic/organic surrounding material is derived from (a) condensation of one or more organofunctional silanes or condensation of one or more organofunctional silanes and tetraalkoxysilane on the surface of the superficially porous core, or (b) application of a partially condensed organofunctional silane, a mixture of two or more organofunctional silanes, or a mixture of one or more organofunctional silanes with a tetraalkoxysilane on the surface of the superficially porous core wherein said inorganic/organic hybrid material has been surface modified with a surface modifier selected from the group consisting of octyltrichlorosilane, octadecyltrichlorosilane, octyldimethylchlorosilane and octadecyldimethylchlorosilane.