# US 11,439,844 B2 · Systems and methods for shuttle mode radiation delivery > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,439,844 B2 - Document ID: US11439844B2 - Status: Granted - Kind: B2 - Application number: 17/150,977 - Filed: 2021-01-15 - Published: 2021-05-06 - Granted: 2022-09-13 - Earliest claimed: 2017-09-22 - Assignees: RefleXion Medical, Inc. - Applicants: RefleXion Medical, Inc. - Inventors: Debashish Pal; Ayan Mitra; Christopher Eric Brown; Peter Demetri Olcott; Yevgen Voronenko; Rostem Bassalow - Web page: https://patentgrep.com/patent/US11439844B2 ## CPC - A61N 5/1031: {using a specific method of dose optimization} - A61N 5/1001: {using radiation sources introduced into or applied onto the body; brachytherapy} - A61N 5/1045: {using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT} - A61N 5/1049: {for verifying the position of the patient with respect to the radiation beam} - A61N 5/1065: {Beam adjustment} - A61N 5/1067: {in real time, i.e. during treatment} - A61N 5/1069: {Target adjustment, e.g. moving the patient support} - A61N 5/107: {in real time, i.e. during treatment} - A61N 5/1081: {Rotating beam systems with a specific mechanical construction, e.g. gantries} - A61N 5/1036: {Leaf sequencing algorithms} - A61N 5/1039: {using functional images, e.g. PET or MRI} - A61N 5/1075: {for testing, calibrating, or quality assurance of the radiation treatment apparatus} - A61N 2005/1019: {Sources therefor} - A61N 2005/1041: {using a library of previously administered radiation treatment applied to other patients} - A61N 2005/1052: {using positron emission tomography [PET] single photon emission computer tomography [SPECT] imaging} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Systems and methods for shuttle mode radiation delivery are described herein. One method for radiation delivery comprises moving the patient platform through the patient treatment region multiple times during a treatment session. This may be referred to as patient platform or couch shuttling (i.e., couch shuttle mode). Another method for radiation delivery comprises moving the therapeutic radiation source jaw across a range of positions during a treatment session. The jaw may move across the same range of positions multiple times during a treatment session. This may be referred to as jaw shuttling (i.e., jaw shuttle mode). Some methods combine couch shuttle mode and jaw shuttle mode. Methods of dynamic or pipelined normalization are also described. ## Claims ### Claim 1 A radiation delivery system comprising: a gantry; a therapeutic radiation source mounted on the gantry and configured to apply radiation in a radiation treatment beam plane; a platform movable relative to the gantry; and a controller configured to provide instructions to: move a patient, using the patient platform, through the radiation treatment beam plane in a first pass; deliver a first quantity of radiation with the therapeutic radiation source in the first pass; move the patient, using the patient platform, through the radiation treatment beam plane in a second pass; and deliver a second quantity of radiation with the therapeutic radiation source in the second pass. ### Claim 2 (depends on 1) The system of claim 1, wherein the second quantity of radiation is different from the first quantity of radiation. ### Claim 3 (depends on 1) The system of claim 1, wherein the controller is configured to instruct the platform to move to a series of pre-defined platform locations. ### Claim 4 (depends on 1) The system of claim 1, wherein the controller is further configured to calculate a cumulative quantity of radiation that has been delivered after each pass through the radiation treatment beam plane. ### Claim 5 (depends on 1) The system of claim 1, wherein the controller is configured to instruct the platform to move the patient through the radiation treatment beam plane in a third pass and to deliver a third quantity of radiation with the therapeutic radiation source in the third pass. ### Claim 6 (depends on 1) The system of claim 1, wherein moving the patient in the first pass comprises moving the platform from a first location to a second location such that the patient passes through the radiation treatment beam plane, and wherein moving the patient in the second pass comprises moving the platform from the second location to the first location. ### Claim 7 (depends on 6) The system of claim 6, wherein the controller is further configured to instruct the platform to move the patient through the radiation treatment beam plane in a third pass and to deliver a third quantity of radiation in the third pass. ### Claim 8 (depends on 1) The system of claim 1, wherein the delivery of the first quantity of radiation is according to one or more radiation delivery parameters and the delivery of the second quantity of radiation is according to an updated one or more radiation delivery parameters. ### Claim 9 (depends on 8) The system of claim 8, wherein the controller is further configured to calculate a cumulative quantity of radiation that has been delivered after each pass through the radiation treatment beam plane, calculate a radiation fluence difference by comparing the cumulative delivered quantity of radiation with a planned quantity of radiation, and to update the one or more radiation delivery parameters based on the calculated radiation fluence difference. ### Claim 10 (depends on 9) The system of claim 9, wherein the system further comprises an MV detector located on the gantry opposite the therapeutic radiation source and the controller is configured to calculate the cumulative quantity of radiation that has been delivered using MV detector data. ### Claim 11 (depends on 9) The system of claim 9, wherein the one or more radiation delivery parameters comprises radiation delivery system machine instructions. ### Claim 12 (depends on 11) The system of claim 11, wherein the radiation delivery system machine instructions comprise jaw, multi-leaf collimator, platform, and/or gantry instructions. ### Claim 13 (depends on 9) The system of claim 9, wherein the one or more radiation delivery parameters comprises a radiation fluence to be delivered in a pass, and wherein the controller is configured to update the second quantity of radiation according to the radiation fluence to be delivered in a pass. ### Claim 14 (depends on 9) The system of claim 9, wherein the controller is configured to instruct delivery of the calculated radiation fluence difference in a subsequent pass. ### Claim 15 A method for radiation delivery, the method comprising: moving a patient on a patient platform of a radiation therapy system through a radiation treatment beam plane of a therapeutic radiation source in a first pass; delivering a first quantity of radiation with the therapeutic radiation source as the patient passes through the radiation treatment beam plane in the first pass; moving the patient through the radiation treatment beam plane in a second pass; and delivering a second quantity of radiation with the therapeutic radiation source as the patient passes through the radiation treatment beam plane in the second pass. ### Claim 16 (depends on 15) The method of claim 15, wherein the second quantity of radiation is different from the first quantity of radiation. ### Claim 17 (depends on 15) The method of claim 15, wherein moving the patient comprises moving the platform to a series of pre-defined platform locations. ### Claim 18 (depends on 15) The method of claim 15, further comprising moving the patient through the radiation treatment beam plane in a third pass and delivering a third quantity of radiation with the therapeutic radiation source as the patient passes through the radiation treatment beam plane in the third pass. ### Claim 19 (depends on 15) The method of claim 15, wherein moving the patient in the first pass comprises moving the platform from a first location to a second location such that the patient passes through the radiation treatment beam plane. ### Claim 20 (depends on 19) The method of claim 19, wherein moving the patient in the second pass comprises moving the platform from the second location to the first location such that the patient passes through the radiation treatment beam plane. ### Claim 21 (depends on 20) The method of claim 20, further comprising moving the patient through the radiation treatment beam plane in a third pass and to deliver a third quantity of radiation in the third pass, and wherein moving the patient in the third pass comprises moving the platform from the first location to the second location. ### Claim 22 (depends on 15) The method of claim 15, wherein delivering the first quantity of radiation comprises emitting radiation with the therapeutic radiation source according to one or more radiation delivery parameters, and wherein the method further comprises updating the one or more radiation delivery parameters and delivering the second quantity of radiation according to the updated one or more radiation delivery parameters. ### Claim 23 (depends on 22) The method of claim 22, further comprising calculating a cumulative quantity of radiation that has been delivered after each pass, calculating a radiation fluence difference by comparing the cumulative delivered quantity of radiation with a planned quantity of radiation, and updating the one or more radiation delivery parameters based on the calculated radiation fluence difference. ### Claim 24 (depends on 23) The method of claim 23, wherein calculating the cumulative quantity of radiation that has been delivered comprises using MV detector data located across from the therapeutic radiation source. ### Claim 25 (depends on 23) The method of claim 23, wherein the one or more radiation delivery parameters comprises radiation delivery system machine instructions. ### Claim 26 (depends on 25) The method of claim 25, wherein the radiation delivery system machine instructions comprise jaw, multi-leaf collimator, platform, and/or gantry instructions. ### Claim 27 (depends on 23) The method of claim 23, wherein the one or more radiation delivery parameters comprises a radiation fluence to be delivered in a pass, and wherein delivering the second quantity of radiation comprises updating the radiation fluence according to the radiation fluence to be delivered in a pass. ### Claim 28 (depends on 23) The method of claim 23, further comprising delivering the calculated radiation fluence difference in a subsequent pass. ### Claim 29 (depends on 15) The method of claim 15, further comprising calculating a cumulative quantity of radiation that has been delivered after each pass through the radiation treatment beam plane.