# US 11,439,841 B2 · Methods and devices for treatment of subcutaneous fat > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,439,841 B2 - Document ID: US11439841B2 - Status: Granted - Kind: B2 - Application number: 16/608,848 - Filed: 2018-05-01 - Published: 2020-06-25 - Granted: 2022-09-13 - Earliest claimed: 2017-05-18 - Assignees: Lightfective Ltd - Applicants: Lightfective Ltd. - Inventors: Yotam Zimmerman - Web page: https://patentgrep.com/patent/US11439841B2 ## CPC - A61B 18/203: {applying laser energy to the outside of the body} - A61N 5/0625: {Warming the body, e.g. hyperthermia treatment} - A61H 7/005: {hand-held} - A61H 9/0057: {Suction (suction kneading A61H7/008)} - A61H 15/02: adapted for simultaneous treatment with light, heat or drugs - A61B 2018/00005: {Cooling or heating of the probe or tissue immediately surrounding the probe} - A61B 2018/00464: {Subcutaneous fat, e.g. liposuction, lipolysis} - A61H 2201/0207: heated - A61H 2201/0214: cooled - A61H 2207/00: Anti-cellulite devices - A61N 5/0616: {Skin treatment other than tanning} - A61N 2005/005: {for cooling the radiator} - A61N 2005/007: {for cooling the patient} - A61N 2005/0632: {Constructional aspects of the apparatus} - A61N 2005/0643: {Applicators, probes irradiating specific body areas in close proximity} - A61N 2005/0652: {Arrays of diodes} - A61N 2005/0659: {infrared} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61H: PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY (electrotherapy, magnetotherapy, radiation therapy or ultrasound therapy A61N) ## Abstract Disclosed are methods and devices suitable for transdermally killing adipocytes in a subcutaneous fat layer of a human subject. ## Claims ### Claim 1 A skin illumination device for treating subcutaneous fat of a subject, comprising: a panel that comprises: a plurality of LEDs operable to generate light in a near-infrared range to transdermally heat subcutaneous fat of the subject, the LEDs being arranged in a matrix with rows; a substrate for positioning proximate to epidermis of the subject, the substrate being transparent to permit light from the LEDs to pass through; a frame to which the LEDs and the substrate are mounted, the frame having a plurality of coolant conduits located between the rows of the LEDs, the coolant conduits being configured to transport a cooling-liquid to cool the LEDs and the substrate; a generator configured to generate a pulsed electromagnetic field having a field strength of between 10 Gauss and 30 Gauss and a frequency of between 0.1 Hz and 100 Hz; and wherein each LED is individually activatable and is operable to be activated alone or together with all or a portion of the other LEDs. ### Claim 2 (depends on 1) The skin illumination device of claim 1, wherein separation between the LEDs in the matrix of LEDs is 0.5 cm to 2 cm. ### Claim 3 (depends on 1) The skin illumination device of claim 1, wherein each LED emits 1000 mW of near-infrared light. ### Claim 4 (depends on 1) The skin illumination device of claim 1, wherein the panel is configured to produce an illumination light with a cross-sectional area of 35 cm2. ### Claim 5 (depends on 1) The skin illumination device of claim 1, wherein the panel is configured to produce an illumination light, with a power density of 1.6 W/cm2, and wherein an intensity of illumination that passes through epidermis and dermis is sufficient to heat adipocytes to a temperature of above 42° C. ### Claim 6 (depends on 1) The skin illumination device of claim 1, wherein the substrate is a sapphire window, wherein one surface of the sapphire window is configured to contact the frame with the coolant conduits, and another surface of the sapphire window is configured to contact epidermis of the subject. ### Claim 7 (depends on 1) The skin illumination device of claim 1, wherein the frame is comprised of aluminum, and wherein the coolant conduits are configured to transport a cooling-liquid with a cooling capacity of at least 0.3 W/cm2. ### Claim 8 (depends on 1) The skin illumination device of claim 1, wherein the panel is a first panel and wherein the skin illumination device further comprises a second panel comprising a second substrate and plurality of second LEDs mounted to a second frame, the second LEDs being operable to generate light in a near-infrared range to transdermally heat subcutaneous fat of the subject; and wherein the first and second panels are oriented at an angle to each other and form an irradiation enclosure, and wherein the angle between the first and second panels is at least 30 degrees. ### Claim 9 (depends on 8) The skin illumination device of claim 8, further comprising a sealing rim that is configured to contact epidermis of the subject. ### Claim 10 (depends on 8) The skin illumination device of claim 8, further comprising a suction system that is operable to draw tissue of the subject into the irradiation enclosure. ### Claim 11 (depends on 1) The skin illumination device of claim 1, wherein a plurality of the LEDs forming the matrix of LEDs are configured to generate and project an illumination light, consisting of wavelengths of 850 nm to 1100 nm and wherein wavelengths of the plurality of the LEDs are selected to effectively pass-through epidermis and dermis of the subject. ### Claim 12 (depends on 1) The skin illumination device of claim 1, wherein the near-infrared range of light generated by the LEDs is selected from the group of ranges consisting of: 900 nm to 920 nm, 940 nm to 960 nm and 1010 nm to 1100 nm; and wherein the generator is a pulsed electromagnetic field generator comprising a coil with a ferromagnetic core for generating the pulsed electromagnetic field. ### Claim 13 A method for cosmetic treatment of skin of a subject, comprising: providing a skin illumination device having a panel with a matrix of LEDs configured to generate light in near-infrared range; applying the panel of the skin illumination device to epidermis of the subject; operating the skin illumination device to generate light in a near-infrared range with wavelengths selected to penetrate through the epidermis and dermis of the subject; employing an intensity of the light to penetrate through the epidermis and the dermis to heat adipocytes in a portion of a subcutaneous fat layer of the subject; concurrently applying a pulsed electromagnetic field to the volume of tissue that includes the subcutaneous fat layer; wherein the pulsed electromagnetic field has a field strength of not less than 10 Gauss and not more than 30 Gauss and has a magnetic pulse frequency of not less than 0.1 Hz and not more than 100 Hz; and initiating adipocytes apoptosis and destroying adipocytes. ### Claim 14 (depends on 13) The method for cosmetic treatment of skin of claim 13, wherein the intensity of the light employed causes the light to heat the adipocytes to a temperature of above 42° C. ### Claim 15 (depends on 13) The method for cosmetic treatment of skin of claim 13, further comprising: concurrently with applying light to a portion of epidermis sufficiently, cooling the illuminated portion of epidermis to prevent burn damage to the epidermis. ### Claim 16 (depends on 15) The method for cosmetic treatment of skin of claim 15, wherein the cooling comprises contacting the portion of epidermis with a cooling surface of a sapphire window having a temperature of 5° C. to 20° C. ### Claim 17 (depends on 13) The method for cosmetic treatment of skin of claim 13, wherein the operating of the skin illumination device to generate light comprises operating a plurality of LEDs forming the matrix of LEDs to generate an illumination light consisting of wavelengths of 850 nm to 1100 nm and having a power density in a range from 0.3 W/cm2 to 5 W/cm2. ### Claim 18 (depends on 13) The method for cosmetic treatment of skin of claim 13, wherein the operating of the skin illumination device comprises generating the illumination light continuously with a duration of at least 10 minutes. ### Claim 19 A method for cosmetic treatment of a portion of a human body, comprising: employing an incoherent multi-source and multi-wavelength illumination light for, transdermally heating a portion of a subcutaneous fat layer of a subject and wherein illumination at a surface of epidermis has a cross-sectional area with dimensions of 35 cm2 with a power density of 1.6 W/cm2, the heating sufficient to destroy at least one adipocyte in the portion of the subcutaneous fat layer and to initiate apoptosis thereof; applying a pulsed electromagnetic field to the volume of tissue that includes the subcutaneous fat layer, the electromagnetic field having a field strength of between 10 Gauss and 30 Gauss and a frequency of between 0.1 Hz and 100 Hz; and cooling the portion of epidermis sufficiently to prevent burn damage to the epidermis; and wherein the illumination includes wavelengths in a near-infrared range of 850 nm to 1100 nm.