# US 11,439,809 B2 · Systems, devices, and methods for ovarian denervation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,439,809 B2 - Document ID: US11439809B2 - Status: Granted - Kind: B2 - Application number: 16/121,582 - Filed: 2018-09-04 - Published: 2019-03-21 - Granted: 2022-09-13 - Earliest claimed: 2017-09-21 - Assignees: Covidien LP - Applicants: Covidien LP - Inventors: Dale E. Whipple; Mireille K. Akilian; Nikolai D. Begg; Chad A. Pickering - Web page: https://patentgrep.com/patent/US11439809B2 ## CPC - A61N 1/0524: {Vaginal electrodes} - A61B 8/12: in body cavities or body tracts, e.g. by using catheters - A61B 17/32: Surgical cutting instruments ({A61B18/042 takes precedence; suture cutters A61B17/0467;} implements for ligaturing and cutting {A61B17/122, A61B17/12; instruments for rupturing the amniotic membrane A61B17/4208; specially adapted knives for eye surgery A61F9/0133}) - A61B 17/320068: {using mechanical vibrations, e.g. ultrasonic (A61B17/22012 takes precedence; dental tooth drilling devices operated by vibration A61C3/03; removing intra-ocular material using mechanical vibrations A61F9/00745)} - A61B 18/0206: {ultrasonic, e.g. for destroying tissue or enhancing freezing} - A61B 18/042: {using additional gas becoming plasma} - A61B 18/14: Probes or electrodes therefor - A61B 18/1485: {having a short rigid shaft for accessing the inner body through natural openings} - A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)} - A61B 18/1815: {using microwaves} - A61M 29/02: Dilators made of swellable material {(balloon catheters for angioplasty A61M25/104)} - A61N 1/0521: {Genital electrodes} - A61N 1/44: Applying ionised fluids {(ion generators H01J37/00)} - A61N 5/022: {Apparatus adapted for a specific treatment} - A61N 7/022: {intracavitary} - A61B 17/22012: {in direct contact with, or very close to, the obstruction or concrement (for removing obstructions in blood vessels by laser A61B18/245)} - A61B 17/32002: {with continuously rotating, oscillating or reciprocating cutting instruments} - A61B 17/42: Gynaecological or obstetrical instruments or methods {(ligaturing clamps or clips for the umbilical cord A61B17/122; curettage A61B17/320708)} - A61B 18/24: with a catheter (A61B18/26, A61B18/28 take precedence) - A61B 2017/22051: {with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation (A61B2017/22048, A61B2017/3486 take precedence)} - A61B 2017/320008: {Scrapers} - A61B 2017/320069: {for ablating tissue} - A61B 2018/00404: {Blood vessels other than those in or around the heart} - A61B 2018/00434: {Neural system} - A61B 2018/00559: {Female reproductive organs} - A61B 2018/00577: {Ablation} - A61B 2018/0212: {using an instrument inserted into a body lumen, e.g. catheter} - A61B 2018/1861: {with an instrument inserted into a body lumen or cavity, e.g. a catheter} - A61B 2090/3784: {both receiver and transmitter being in the instrument or receiver being also transmitter} - A61M 2205/3368: Temperature - A61M 2205/3375: Acoustical, e.g. ultrasonic, measuring means - A61M 2210/1408: Ovaries - A61N 1/36057: {adapted for stimulating afferent nerves} - A61N 1/36062: {Spinal stimulation} - A61N 1/36103: {Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke} - A61N 2007/003: {Destruction of nerve tissue} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract Methods for effectuating ovarian denervation include advancing a disruptor intravaginally to access an ovarian nerve and applying the disruptor to the ovarian nerve to denervate the ovarian nerve to limit ovarian sympathetic neural activity and control hormonal secretion. ## Claims ### Claim 1 A method for effectuating ovarian denervation, the method comprising: fixedly implanting at least one electrode within a portion of an ovarian vessel within an infundibulopelvic ligament of a person; fixedly implanting at least one additional electrode adjacent the ovarian vessel and adjacent the infundibulopelvic ligament of the person; and activating the at least one electrode and the at least one additional electrode after fixedly implanting the at least one electrode and the at least one additional electrode to disrupt an overactive ovarian nerve by applying an intermittent electrical signal to the overactive ovarian nerve to provide a therapeutic treatment to the overactive ovarian nerve, wherein the at least one additional electrode is activated through a wired connection extending into the infundibulopelvic ligament of the person, and wherein the at least one electrode and the at least one additional electrode remain fixedly implanted for at least a duration of the therapeutic treatment provided to the overactive ovarian nerve. ### Claim 2 (depends on 1) The method of claim 1, wherein activating the at least one additional electrode includes intermittently conducting electrical energy through the at least one additional electrode to disrupt sympathetic nerve signals of the overactive ovarian nerve. ### Claim 3 (depends on 1) The method of claim 1, wherein activating the at least one electrode includes intermittently passing electrical energy through the at least one electrode to disrupt sympathetic nerve signals of the overactive ovarian nerve. ### Claim 4 (depends on 3) The method of claim 3, wherein activating the at least one additional electrode includes intermittently passing electrical energy through the at least one additional electrode to disrupt sympathetic nerve signals of the overactive ovarian nerve. ### Claim 5 (depends on 1) The method of claim 1, wherein the intermittent electrical signal is applied to the at least one electrode and the at least one additional electrode from an electrosurgical generator positioned outside a body of the person. ### Claim 6 (depends on 5) The method of claim 5, wherein the at least one electrode is connected to the electrosurgical generator by a second wired connection and the at least one additional electrode is connected with the electrosurgical generator by the wired connection separate from the second wired connection, and wherein the electrosurgical generator applies electrical energy to the at least one electrode through the second wired connection and the electrosurgical generator applies electrical energy to the at least one additional electrode through the wired connection. ### Claim 7 A method for effectuating ovarian denervation, the method comprising: fixedly implanting at least one electrode within a portion of an ovarian vessel within an infundibulopelvic ligament of a person; fixedly implanting at least one additional electrode adjacent the infundibulopelvic ligament of the person; and activating the at least one electrode or the at least one additional electrode after fixedly implanting the at least one electrode or the at least one additional electrode to disrupt an overactive ovarian nerve by applying an intermittent electrical signal to the overactive ovarian nerve to provide a therapeutic treatment to the overactive ovarian nerve, wherein the at least one additional electrode is activated through a wired connection extending into the infundibulopelvic ligament of the person, and wherein the at least one electrode and the at least one additional electrode remain fixedly implanted for at least a duration of the therapeutic treatment provided to the overactive ovarian nerve. ### Claim 8 (depends on 7) The method of claim 7, wherein activating the at least one additional electrode includes intermittently conducting electrical energy through the at least one additional electrode to disrupt sympathetic nerve signals of the overactive ovarian nerve. ### Claim 9 (depends on 7) The method of claim 7, wherein activating the at least one electrode includes intermittently passing electrical energy through the at least one electrode to disrupt sympathetic nerve signals of the overactive ovarian nerve. ### Claim 10 (depends on 9) The method of claim 9, wherein activating the at least one additional electrode includes intermittently passing electrical energy through the at least one additional electrode to disrupt sympathetic nerve signals of the overactive ovarian nerve. ### Claim 11 (depends on 7) The method of claim 7, wherein the intermittent electrical signal is applied to the at least one electrode and the at least one additional electrode from an electrosurgical generator positioned outside a body of the person. ### Claim 12 (depends on 11) The method of claim 11, wherein the at least one electrode is connected to the electrosurgical generator by a second wired connection and the at least one additional electrode is connected with the electrosurgical generator by the wired connection separate from the second wired connection, and wherein the electrosurgical generator applies electrical energy to the at least one electrode through the second wired connection and the electrosurgical generator applies electrical energy to the at least one additional electrode through the wired connection.