# US 11,439,760 B2 · Syringes

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- Number: US 11,439,760 B2
- Document ID: US11439760B2
- Status: Granted
- Kind: B2
- Application number: 16/510,955
- Filed: 2019-07-14
- Published: 2021-01-14
- Granted: 2022-09-13
- Earliest claimed: 2019-07-14
- Applicants: Nilesh Parikh; William Hite
- Inventors: Nilesh Parikh; William Hite
- Web page: https://patentgrep.com/patent/US11439760B2

## CPC

- A61M 5/31525: {Dosing (burettes, pipettes B01L3/02)}
- A61M 5/1412: {Burettes, measuring cylinders (for laboratory use B01L3/02)}
- A61M 5/3129: {Syringe barrels (A61M5/3205, A61M5/50 take precedence)}
- A61M 5/002: {Packages specially adapted therefor, e.g. packages for syringes or needles or kits for diabetics}
- A61M 5/28: Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M 2005/3126: {related to dosing}
- G09F 2003/0272: {Labels for containers}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- G09F: DISPLAYING; ADVERTISING; SIGNS; LABELS OR NAME-PLATES; SEALS

## Abstract

Embodiments of this invention provide syringes calibrated for use with a predetermined liquid medication having an active pharmaceutical ingredient (API) at a particular weight per unit volume (w/v) concentration. Such syringes comprising a plunger and a barrel are configured such that the plunger, and/or an end portion of the plunger, is sealingly receivable through an opening at one end the barrel and within the barrel and slidingly moveable lengthwise within the barrel. This configuration allows formation of a reservoir inside the barrel into which the liquid medication may be loaded through an intake opening for the liquid medication at the other end of the barrel. Syringe barrels according to this invention possess line increments that form two or more graduated scales of API weight dosages extending lengthwise along the barrels. The increment lines provide for highly precise and accurate measurement of fine-increment weight dosages of the API.

## Claims

### Claim 1

A syringe, calibrated for use with a predetermined liquid medication having a particular active pharmaceutical ingredient (API) at a particular weight per unit volume (w/v) concentration, the syringe comprising: a plunger and a barrel configured such that the plunger, or an end portion of the plunger, is sealingly receivable through an opening at one end of the barrel and within the barrel and slidingly moveable lengthwise within the barrel, which configuration forms a volumetrically adjustable reservoir inside the barrel into which only a single API weight dosage of the liquid medication is loaded through an intake opening for the liquid medication at the other end of the barrel,
wherein:
the barrel is made, in whole or in part, from substantially transparent material through which liquid medication inside the reservoir is visible;
the barrel comprises, extending along its lengthwise axis, two or more graduated scales of liquid medication API weight dosages on the substantially transparent material of the barrel, each of the two or more graduated scales occupying non-overlapping arcs running lengthwise along the circumference of the barrel;
each graduated scale is formed of a plurality of increment API weight dosage lines for the liquid medication, each increment line running perpendicular to the lengthwise axis of the barrel and immediately adjacent increment lines of any one graduated scale indicating API weight dosages that differ from each other by no more than 100 mg;
increment lines of one graduated scale are offset, along the lengthwise axis of the barrel, from increment lines of the other graduated scales;
at least every fifth increment line of any one graduated scale is labeled with the weight dosage of the API indicated thereby and such label is the only writing on the syringe unless the syringe is also marked with the name of the API, the medication, or both; and
the increment lines of all the graduated scales are arranged on the barrel in a manner such that, moving in a spiral fashion along the lengthwise axis of the barrel from any one increment line of a first graduated scale to another increment line of a second graduated scale that is closest in proximity to the one increment line, the one and the another increment lines indicate API weight dosages that differ front each other by no more than 50 mg.

### Claim 2 (depends on 1)

The syringe of claim 1, wherein a maximum API weight dosage indicated by any graduated scale corresponds to a volume of the liquid medication loaded into the reservoir that is 1 ml, 2 ml, 3 ml, 5 ml, 10 ml, 15 mL, 20 ml, 25 ml, or 50 ml.

### Claim 3 (depends on 2)

The syringe of claim 2, wherein each increment line and each increment line label is printed, stamped, embossed, engraved, and/or etched onto the barrel.

### Claim 4 (depends on 3)

The syringe of claim 3, wherein the syringe is calibrated for use with the predetermined liquid medication having the particular API w/v concentration that that falls in a range of 1 mg/ml to 999 mg/ml.

### Claim 5 (depends on 4)

The syringe of claim 4, wherein each immediately adjacent increment line of any one graduated scale indicate API weight dosages that differ from each other by no more than 90 mg, 80 mg, 70 mg, 60 mg, 50 mg, 40 mg, 30 mg, 20 mg, 15 mg, 10 mg, or 5 mg.

### Claim 6 (depends on 5)

The syringe of claim 5, wherein the API has a narrow therapeutic index.

### Claim 7 (depends on 6)

The syringe of claim 6, wherein the collection of increment lines of all the graduated scales are arranged on the barrel in a manner such that, moving in a spiral fashion along the lengthwise axis of the barrel from any one increment line of a first graduated scale to another increment line of a second graduated scale that is closest in proximity to the one increment line, the one and the another increment lines indicate API weight dosages that differ from each other by no more than 10 mg.

### Claim 8

A syringe, calibrated for use with a predetermined liquid medication having a particular active pharmaceutical ingredient (API) at a particular weight per unit volume (w/v) concentration, the syringe comprising: a plunger and a barrel configured such that the plunger, or an end portion of the plunger, is sealingly receivable through an opening at one end of the barrel and within the barrel and slidingly moveable lengthwise within the barrel, which configuration forms a volumetrically adjustable reservoir inside the barrel into which only a single API weight dosage of the liquid medication is loaded through an intake opening for the liquid medication at the other end of the barrel, wherein:
the barrel is made, in whole or in part, from substantially transparent material through which liquid medication inside the reservoir is visible;
the barrel comprises, extending along its lengthwise axis, two or more graduated scales of liquid medication API weight dosages on the substantially transparent material of the barrel, each of the two or more graduated scales occupying non-overlapping arcs running lengthwise along the circumference of the barrel;
each graduated scale is formed of a plurality of increment API weight dosage lines for the liquid medication, each increment line running perpendicular to the lengthwise axis of the barrel and immediately adjacent increment lines of any one graduated scale indicating API weight dosages that differ from each other by no more than 100 ug;
increment lines of one graduated scale are offset, along the lengthwise axis of the barrel, from increment lines of the other graduated scales; and
at least every fifth increment line of any one graduated scale is labeled with the weight dosage of the API indicated thereby such label is the only writing on the syringe unless the syringe is also marked with the name of the API, the medication, or both; and
the increment lines of all the graduated scales are arranged on the barrel in a manner such that, moving in a spiral fashion along the lengthwise axis of the barrel from any one increment line of a first graduated scale to another increment line of a second graduated scale that is closest in proximity to the one increment line the one and the another increment lines indicate API weight dosages that differ from each other by no more than 50 ug.

### Claim 9 (depends on 8)

The syringe of claim 8, wherein a maximum API weight dosage indicated by any graduated scale corresponds to a volume of the liquid medication loaded into the reservoir that is 1 ml, 2 ml, 3 ml, 5 ml, 10 ml, 15 mL, 20 ml, 25 ml, or 50 ml.

### Claim 10 (depends on 9)

The syringe of claim 9, wherein each increment line and each increment line label is printed, stamped, embossed, engraved, and/or etched onto the barrel.

### Claim 11 (depends on 10)

The syringe of claim 10, wherein the syringe is calibrated for use with the predetermined liquid medication having the particular API w/v concentration that falls in a range of 1 μg/ml to 999 μg/ml.

### Claim 12 (depends on 11)

The syringe of claim 11 wherein each immediately adjacent increment line of any one graduated scale indicate API weight dosages that differ from each other by no more than 90 μg, 80 μg, 70 μg, 60 μg, 50 μg, 40 μg, 30 μg, 20 μg, 15 μg, 10 μg, or 5 μg.

### Claim 13 (depends on 12)

The syringe of claim 12, wherein the API is levothyroxine or a pharmaceutically acceptable salt of levothyroxine.

### Claim 14 (depends on 13)

The syringe of claim 13, wherein there are three graduated scales on the barrel, and wherein a maximum API weight dosage indicated by any graduated scale corresponds to a volume of the liquid medication loaded into the reservoir that is 3 ml or 5 ml.

### Claim 15 (depends on 14)

The syringe of claim 14, wherein the graduated scales are calibrated for use with the predetermined liquid medication having the particular API w/v concentration that is 30 μg/ml or 50 μg/ml.

### Claim 16 (depends on 15)

The syringe of claim 15, wherein immediately adjacent increment lines of any one graduated scale indicate levothyroxine or a physiologically acceptable salt thereof weight dosages that differ from each other by 15 μg or less.

### Claim 17

A syringe, calibrated for use with a predetermined liquid medication having a particular active pharmaceutical ingredient (API) at a particular weight per unit volume (w/v) concentration, the syringe comprising: a plunger and a barrel configured such that the plunger, or an end portion of the plunger, is sealingly receivable through an opening at one end of the barrel and within the barrel and slidingly moveable lengthwise within the barrel, which configuration forms a volumetrically adjustable reservoir inside the barrel into which only a single API weight dosage of the liquid medication is loaded through an intake opening for the liquid medication at the other end of the barrel, wherein:
the barrel is made, in whole or in part, from substantially transparent material through which liquid medication inside the reservoir is visible;
the barrel comprises, extending along its lengthwise axis, three graduated scales of liquid medication API weight dosages on the substantially transparent material of the barrel, each of the three graduated scales occupying non-overlapping arcs running lengthwise along the circumference of the barrel;
each graduated scale is formed of a plurality of increment API weight dosage lines for the liquid medication, each increment line running perpendicular to the lengthwise axis of the barrel and immediately adjacent increment lines of any one graduated scale indicating API weight dosages that differ from each other by no more than 13 micrograms;
increment lines of one graduated scale are offset, along the lengthwise axis of the barrel, from increment lines of the other graduated scales; every increment line of any one graduated scale is labeled with the weight dosage of the API indicated thereby and such label is only writing on the syringe unless the syringe is also marked with the name of the API, the medication, or both; and
the increment lines of all the graduated scales are arranged on the barrel in a manner such that, moving in a spiral fashion along the lengthwise axis of the barrel from any one increment line of a first graduated scale to another increment line of a second graduated scale that is closest in proximity to the one increment line, the one and the another increment lines indicate API weight dosages that differ from each other by not more than 50 ug.