# US 11,439,757 B2 · Medical delivery device with laminated stopper > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,439,757 B2 - Document ID: US11439757B2 - Status: Granted - Kind: B2 - Application number: 16/591,844 - Filed: 2019-10-03 - Published: 2020-02-27 - Granted: 2022-09-13 - Earliest claimed: 2016-01-15 - Assignees: W. L. Gore & Associates, Inc. - Applicants: W.L. Gore & Associates, Inc. - Inventors: Greg Rusch; Robert C. Basham - Web page: https://patentgrep.com/patent/US11439757B2 ## CPC - A61M 5/31505: {Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit} - A61L 31/048: {obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence)} - A61L 31/10: Macromolecular materials - A61M 5/3129: {Syringe barrels (A61M5/3205, A61M5/50 take precedence)} - A61M 5/31513: {Piston constructions to improve sealing or sliding} - A61M 2005/3101: {Leak prevention means for proximal end of syringes, i.e. syringe end opposite to needle mounting end} - A61M 2005/3131: {specially adapted for improving sealing or sliding} - A61M 2005/31506: {formed as a single piece, e.g. moulded} - A61M 2205/0216: Materials providing elastic properties, e.g. for facilitating deformation and avoid breaking - A61M 2205/0222: Materials for reducing friction - A61M 2205/0238: the material being a coating or protective layer - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract The present disclosure relates to a medical delivery device that includes a barrel having an inner surface, a plunger rod having a distal end inserted within the barrel, and a stopper attached to the distal end of the plunger rod and contacting at least a portion of the inner surface of the barrel. In at least one embodiment, the inner surface is hydrophilic. The stopper may include an elastomeric body, one or more fluoropolymer layers, and two or more ribs laminated with the one or more fluoropolymer layers. In some embodiments, the contact width between at least one rib having a sealing surface and the portion of the inner surface of the barrel measured at a compressibility of greater than about 7.9% of the stopper is less than about 1.0 mm. ## Claims ### Claim 1 A medical delivery device comprising: a barrel containing at least one therapeutic; a plunger rod having a distal end inserted within the barrel; a stopper attached to the distal end of the plunger rod and contacting at least a portion of the inner surface of the barrel, the stopper comprising an elastomeric body, one or more fluoropolymer layers, and two or more ribs having a sealing surface and being positioned on the one or more fluoropolymer layers; wherein a contact width between at least one of said two or more ribs and a portion of the inner surface of the barrel measured at a compressibility of greater than about 7.9% of the stopper is less than about 1.0 mm. ### Claim 2 (depends on 1) The medical delivery device of claim 1, wherein said barrel is a silicone free syringe barrel. ### Claim 3 (depends on 1) The medical delivery device of claim 1, wherein said therapeutic comprises at least one bioactive selected from coagulation factors, cytokines, epigenetic protein families, growth factors, hormones, peptides, signal transduction molecules, vaccines, and combinations thereof. ### Claim 4 (depends on 1) The medical delivery device of claim 1, wherein said therapeutic comprises mutations of a bioactive selected from coagulation factors, cytokines, epigenetic protein families, growth factors, hormones, peptides, signal transduction molecules, vaccines, and combinations thereof. ### Claim 5 (depends on 1) The medical delivery device of claim 1, wherein said therapeutic comprises at least one bioactive selected from protein kinases, esterases, phosphatases, ion channels, proteases, structural proteins, membrane transport proteins, nuclear hormone receptors, and mutations and combinations thereof. ### Claim 6 (depends on 1) The medical delivery device of claim 1, wherein said therapeutic comprises at least one bioactive selected from antibodies, antisense, RNA interference, target receptors, and combinations thereof. ### Claim 7 (depends on 1) The medical delivery device of claim 1, wherein said therapeutic comprises at least one bioactive selected from primary and embryonic stem cells. ### Claim 8 (depends on 1) The medical delivery device of claim 1, wherein the therapeutic is factor VII. ### Claim 9 (depends on 1) The medical delivery device of claim 1 used for treatment of ocular disease.