# US 11,439,740 B2 · Removable biocompatible substrate filter for a reaming and collection device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,439,740 B2 - Document ID: US11439740B2 - Status: Granted - Kind: B2 - Application number: 16/385,785 - Filed: 2019-04-16 - Published: 2019-08-08 - Granted: 2022-09-13 - Earliest claimed: 2010-04-21 - Assignees: Genesis Medical Devices LLC - Applicants: Genesis Medical Devices, LLC - Inventors: Daniel Nick Segina; James A. Proctor, Jr. - Web page: https://patentgrep.com/patent/US11439740B2 ## CPC - A61M 1/60: {Containers for suction drainage, adapted to be used with an external suction source (containers not adapted for subjection to vacuum A61M1/69)} - A61B 10/025: {for taking bone, bone marrow or cartilage samples} - A61B 17/1635: {for grafts, harvesting or transplants} - A61K 35/28: Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells - A61L 27/3608: {Bone, e.g. demineralised bone matrix [DBM], bone powder} - A61L 27/365: {Bones} - A61L 27/3691: {characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation} - A61M 1/79: {Filters for solid matter (specially adapted for dental use A61C17/065)} - A61P 41/00: Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution - A61B 10/0283: {with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe (A61B10/025, A61B10/0266 take precedence)} - A61B 2010/0258: {Marrow samples} - A61B 2017/00004: {(bio)absorbable, (bio)resorbable or resorptive} - A61B 2017/00969: {used for transplantation} - A61B 2217/005: with suction drainage system - A61B 2217/007: with irrigation system - A61M 2202/0014: removed from the body - A61M 2202/0021: removed from and reintroduced into the body, e.g. after treatment - A61M 2202/005: residue retained by the filter due to size - A61M 2202/10: Bone-marrow - A61M 2205/7545: for solid matter, e.g. microaggregates - A61M 2210/02: Bones - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A removable second stage biocompatible substrate filter including biocompatible implant material configured to trap second stage operative particulate matter, wherein the removable second stage biocompatible substrate filter is configured to combine with first stage operative particulate matter captured from irrigation fluid by a first stage filter, defining a combined product and the removable second stage biocompatible substrate filter is configured to be removable from a filter device container. ## Claims ### Claim 1 A removable second stage biocompatible substrate filter comprising: biocompatible implant material configured to trap second stage operative particulate matter; wherein the removable second stage biocompatible substrate filter is configured to combine with first stage operative particulate matter captured from irrigation fluid by a first stage filter, defining a combined product; and wherein the removable second stage biocompatible substrate filter is configured to be removable from a filter device container. ### Claim 2 (depends on 1) The removable second stage biocompatible substrate filter of claim 1 wherein the second stage operative particulate matter includes at least one of bone fragments, stem cells, cellular matter, and growth factors captured from irrigation fluid. ### Claim 3 (depends on 1) The removable second stage biocompatible substrate filter of claim 1 wherein the first stage operative particulate matter is a first size; and wherein the second stage operative particulate matter is a second size. ### Claim 4 (depends on 1) The removable second stage biocompatible substrate filter of claim 1 wherein the removable second stage biocompatible substrate filter is a porous and hydrophilic membrane configured as an implantable product for implantation within humans. ### Claim 5 (depends on 4) The removable second stage biocompatible substrate filter of claim 4 wherein the removable second stage biocompatible substrate filter is configured as an implantable product; and wherein the first stage operative particulate matter conforms to a size and geometric shape consistent with an undulated surface of the second stage filter. ### Claim 6 (depends on 1) The removable second stage biocompatible substrate filter of claim 1 wherein the second stage biocompatible substrate filter is contained in a centrifuge. ### Claim 7 (depends on 1) The removable second stage biocompatible substrate filter of claim 1 wherein the combined product is configured to unroll into sheets. ### Claim 8 (depends on 1) The removable second stage biocompatible substrate filter of claim 1 wherein the removable second stage biocompatible substrate filter is configured to be operable with a reaming and collection device. ### Claim 9 A removable second stage biocompatible substrate filter comprising: biocompatible implant material configured to retain second stage operative particulate matter; wherein the removable second stage filter is configured to combine with first stage operative particulate matter captured from irrigation fluid by a first stage filter, defining a combined product; wherein the first stage operative particulate matter includes material of a first size; and wherein the second stage operative particulate matter includes material of a second size. ### Claim 10 (depends on 9) The removable second stage biocompatible substrate filter of claim 9 wherein the removable second stage biocompatible substrate filter is configured to be operable with a reaming and collection device. ### Claim 11 (depends on 9) The removable second stage biocompatible substrate filter of claim 9 wherein the second stage operative particulate matter retained is one of bone fragments, plasma, stem cells, cellular matter, and growth factors captured from irrigation fluid. ### Claim 12 (depends on 9) The removable second stage biocompatible substrate filter of claim 9 wherein the removable second stage biocompatible substrate filter is configured to receive first stage operative particulate matter that includes bone fragments. ### Claim 13 (depends on 9) The removable second stage biocompatible substrate filter of claim 9 wherein the removable second stage biocompatible substrate filter is configured to receive first stage operative particulate matter that includes at least one of bone fragments, plasma, stem cells, cellular matter, and growth factors captured from irrigation fluid. ### Claim 14 A removable second stage biocompatible substrate filter comprising: biocompatible implant material configured to retain second stage operative particulate matter; wherein the removable second stage biocompatible substrate filter is configured to combine with operative particulate matter captured from irrigation fluid by a first stage filter; wherein the first stage retained material and the second stage retained material are obtained from a reaming device; wherein an output of the reaming device is connected to an input of a first stage filter container; wherein a flow of materials suspended in the irrigation fluid is filtered by the first stage filter; wherein the first stage retained material is separated from the flow of materials suspended in the irrigation fluid by a filter possessing a first particulate size selectivity that provides a first stage output flow of materials suspended in irrigation fluid; wherein the first stage output flow of materials is suspended in the irrigation fluid and passed through a first stage output; wherein an input of a second stage filter container is connected by a second connecting tube to the output of the first stage filter container; wherein the first stage output flow of materials suspended in the irrigation fluid is filtered by the second stage filter; wherein the second stage filter retains a second sized particulate matter different than the first stage filter; wherein the second stage filter collects a portion of at least one or more of plasma, stem cells, growth factors, and cellular matter, and allows for passing of a portion of the irrigation fluid, as output flow; wherein the second stage filter container includes an evacuation port to permit the flow of materials suspended in the irrigation fluid to be evacuated from the second stage filter container in a continuous process; wherein the continuous process further includes the first stage filter container receiving output from the reaming device; and wherein the biocompatible substrate is configured to be removable with at least a portion of the first stage retained material and to create a combined graft product in combination with at least a portion of the second stage retained material. ### Claim 15 (depends on 14) The removable second stage biocompatible substrate filter of claim 14 wherein the substrate is a porous and hydrophilic membrane configured as an implantable product for implantation within humans. ### Claim 16 (depends on 14) The removable second stage biocompatible substrate filter of claim 14 wherein the removable second stage biocompatible substrate filter is configured as an implantable product; and wherein the first stage retained material and the second stage retained material conform to a size and geometric shape consistent with an undulated surface of the second stage filter. ### Claim 17 (depends on 14) The removable second stage biocompatible substrate filter of claim 14 wherein the second stage comprises a centrifuge. ### Claim 18 (depends on 14) The removable second stage biocompatible substrate filter of claim 14 wherein the combined product is configured to unroll into sheets. ### Claim 19 (depends on 14) The removable second stage biocompatible substrate filter of claim 14 wherein the substrate is a porous and hydrophilic membrane of a size and geometric shape consistent with an undulated surface of the second stage filter configured as an implantable product to envelop a human bone.