# US 11,439,733 B2 · Method for producing antithrombotic coating material

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- Number: US 11,439,733 B2
- Document ID: US11439733B2
- Status: Granted
- Kind: B2
- Application number: 16/207,546
- Filed: 2018-12-03
- Published: 2019-04-04
- Granted: 2022-09-13
- Earliest claimed: 2015-03-10
- Assignees: Terumo Kabushiki Kaisha
- Applicants: Terumo Kabushiki Kaisha
- Inventors: Takao Anzai
- Web page: https://patentgrep.com/patent/US11439733B2

## CPC

- A61L 33/064: {obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L33/062 takes precedence)}
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 29/085: {Macromolecular materials}
- A61L 31/10: Macromolecular materials
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Provided is a method for producing an antithrombotic coating material in which a high molecular weight polymer can be obtained by a solution polymerization using a radical polymerization initiator. The above-mentioned task is achieved by a method for producing an antithrombotic coating material, including steps of: preparing a methanol solution containing a monomer represented by formula (1): wherein in formula (1), R1, R2, and R3 are the same as those described in the specification, respectively; adding a radical polymerization initiator having a 10-hour half-life temperature of 60° C. or less to the methanol solution to prepare a polymerization reaction liquid; and polymerizing the monomer.

## Claims

### Claim 1

An antithrombotic coating material, comprising:
polyalkoxyalkyl (meth)acrylate that contains a structural unit (A) represented by formula (2):
wherein in formula (2), R1 represents a hydrogen atom or a methyl group, R2 represents an alkylene group having 1 to 4 carbon atoms, and R3 represents an alkyl group having 1 to 4 carbon atoms,
wherein the polyalkoxyalkyl (meth)acrylate has a weight average molecular weight of 200,000 or more,
wherein the polyalkoxyalkyl (meth)acrylate is dissolved in methanol or a mixture comprising water and methanol,
wherein the polyalkoxyalkyl (meth)acrylate is not a block copolymer, and
wherein the polyalkoxyalkyl (meth)acrylate is composed of 100 mol % of the structural unit (A).

### Claim 2 (depends on 1)

The antithrombotic coating material according to claim 1, wherein a ratio of intermediate water calculated by equation (1) below with respect to the polyalkoxyalkyl (meth)acrylate that is equilibrium-hydrated, exceeds 32%:
Ratio (%) of Intermediate Water=(a/x)×100 Equation (1):
wherein in equation (1), a and x represent an intermediate water content (wt %) and an equilibrium water content (wt %), respectively, in the polyalkoxyalkyl (meth)acrylate that is equilibrium-hydrated.

### Claim 3 (depends on 1)

The antithrombotic coating material according to claim 1, wherein the weight average molecular weight of the polyalkoxyalkyl (meth)acrylate is less than 1,000,000.

### Claim 4 (depends on 1)

The antithrombotic coating material according to claim 1, wherein the weight average molecular weight of the polyalkoxyalkyl (meth)acrylate is in a range of from 400,000 to 800,000.

### Claim 5 (depends on 1)

The antithrombotic coating material according to claim 1, wherein in formula (1), R1 is a hydrogen atom, R2 is a methylene group or an ethylene group, and R3 is a methyl group.

### Claim 6 (depends on 1)

The antithrombotic coating material according to claim 1, wherein the polymer is contained in the antithrombotic coating material in an amount of 0.2 to 10 wt % based on the antithrombotic coating material material.

### Claim 7 (depends on 1)

The antithrombotic coating material according to claim 1, wherein the polyalkoxyalkyl (meth)acrylate is dissolved in a solvent consisting of methanol or a solvent mixture consisting of water and methanol.

### Claim 8 (depends on 1)

A medical device, comprising:
a substrate comprising a polymer material, and
the antithrombotic coating material according to claim 1, wherein the antithrombotic coating material is coated on a surface of the substrate.

### Claim 9 (depends on 1)

The antithrombotic coating material according to claim 1, wherein the weight average molecular weight of the polyalkoxyalkyl (meth)acrylate is in a range of from 200,000 to 800,000.

### Claim 10

An antithrombotic coating material, comprising:
polyalkoxyalkyl (meth)acrylate that contains a structural unit (A) represented by formula (2):
wherein in formula (2), R1 represents a hydrogen atom or a methyl group, R2 represents an alkylene group having 1 to 4 carbon atoms, and R3 represents an alkyl group having 1 to 4 carbon atoms,
wherein the polyalkoxyalkyl (meth)acrylate has a weight average molecular weight in a range of from 200,000 to 800,000,
wherein the polyalkoxyalkyl (meth)acrylate is dissolved in methanol or a mixture comprising water and methanol, and
wherein the polyalkoxyalkyl (meth)acrylate is composed of 100 mol % of the structural unit (A).