# US 11,439,729 B2 · Implantable medical product with permanently negatively charged surface

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- Number: US 11,439,729 B2
- Document ID: US11439729B2
- Status: Granted
- Kind: B2
- Application number: 16/546,693
- Filed: 2019-08-21
- Published: 2020-02-27
- Granted: 2022-09-13
- Earliest claimed: 2018-08-23
- Assignees: Uronova GmbH Medizinische Implantate
- Applicants: UroNova GmbH medizinische Implantate
- Inventors: Peter Hildebrandt
- Web page: https://patentgrep.com/patent/US11439729B2

## CPC

- A61L 27/30: Inorganic materials
- A61L 27/34: Macromolecular materials
- A61K 31/09: having two or more such linkages
- A61K 38/46: Hydrolases (3)
- A61L 27/306: {Other specific inorganic materials not covered by A61L27/303 - A61L27/32}
- A61L 27/32: Phosphorus-containing materials, e.g. apatite
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 29/10: Inorganic materials
- A61L 29/106: {Inorganic materials other than carbon}
- A61L 29/16: Biologically active materials, e.g. therapeutic substances {(A61L29/048 takes precedence)}
- A61L 31/082: {Inorganic materials}
- A61L 31/086: {Phosphorus-containing materials, e.g. apatite}
- A61L 31/088: {Other specific inorganic materials not covered by A61L31/084 or A61L31/086}
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- A61F 2310/0097: Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
- A61L 2300/10: containing or releasing inorganic materials
- A61L 2300/112: Phosphorus-containing compounds, e.g. phosphates, phosphonates
- A61L 2300/202: with halogen atoms, e.g. triclosan, povidone-iodine
- A61L 2300/254: Enzymes, proenzymes
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2300/424: Anti-adhesion agents
- A61L 2300/80: characterised by a special chemical form
- A61L 2420/02: Methods for coating medical devices
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

An entirely or partially implantable medical product with a negatively charged surface for repulsing bacteria has a superficially bonded substance with a permanently negative excess charge, which substance is inert against cells of the human body and the bacteria contained therein.

## Claims

### Claim 1

A medical product, which is either entirely or partially implantable, with a negatively charged surface for repulsing bacteria, comprising a superficially bonded substance with a permanently negative excess charge, which substance, having no pharmacological effect and with the proviso that it is not heparin, is inert against cells of the human body and the bacteria contained therein, wherein the substance carrying negative charges is a sulfonic acid having an amino group and is covalently bonded to the surface via a peptide bond and deprotonated as well as the resulting negative charge being stabilized by the establishment of a mesomerism.

### Claim 2 (depends on 1)

The medical product according to claim 1, wherein the sulfonic acid used is 6-aminonaphthalene-2-sulfonic acid.

### Claim 3 (depends on 1)

The medical product according to claim 1, wherein the substance is deprotonated with the help of diluted sodium hydroxide.