Hypocrellin derivative substituted both in a peri-position and in 2-position by amino, preparation method, and application thereof

A hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino, wherein a general structural formula of the derivative is as represented by formulas I-a to I-d:

• wherein the peri-position of hypocrellin is a 3-, 4-, 9-, or 10-position marked in formulas I-a to I-d;
• a substituent R3 is —COOH3 or —H;
• a substituent R4 is —H, —F, —Cl, —Br, —I, or —S—R5, wherein R5 is a C2-12 alkyl group, a C2-12 alkyl group having a hydroxyl group as a terminal group, or a C2-12 alkyl group having a carboxyl group as a terminal group;
• general structural formulas of substituents R1 and R2 are respectively as represented by formula II:
• in formula II, 0≤m≤8, 0≤n≤50, 0≤p≤8, 0≤q≤8, 0≤r≤1, and 0≤s≤8;
• m, n, p, q, r, and s are respectively zero or a positive integer;
• linking groups X and Y in formula II are respectively —NH—, —O—, —S—, a carboxylate group, an amide group, a sulfonate group, a sulfonamide group, a carbonyl group, a phosphate group, a C3-12 unsaturated hydrocarbyl group, a C3-12 cyclic hydrocarbyl group, a C6-12 aryl group, or a C3-12 heterocyclic group;
• the C3-12 unsaturated hydrocarbyl group is substituted or unsubstituted or heteroatom-containing alkene or alkyne;
• the C3-12 cyclic hydrocarbyl group is substituted or unsubstituted or heteroatom-containing cycloalkane, cycloalkene, or cycloalkyne, and the heteroatom is an oxygen, nitrogen, or sulfur atom;
• the C6-12 aryl group is a substituted or unsubstituted aryl group, wherein the substituted aryl group is a mono- or poly-substituted aryl group, and a substituted position is an ortho-position, a meta-position, or a para-position in the aryl group;
• the C3-12 heterocyclic group is a substituted or unsubstituted heterocyclic group, the substituted heterocyclic group is mono- or poly-substituted, and a substituted position is an ortho-position, a meta-position, or a para-position in a heterocycle;
• the heterocyclic group is furan, pyrrole, thiophene, pyrazole, imidazole, oxazole, thiazole, pyridine, piperidine, pyrimidine, pyrazine, piperazine, indole, quinoline, isoquinoline, purine, pyrimidine, or acridine;
• a substituent in the above cycloalkyl, cycloalkenyl, aryl, or heterocyclic group is respectively a C1-8 alkyl group, a C2-8 alkenyl group, a C2-8 alkynyl group, a C3-8 cycloalkyl group, an aryl group, a C6-12 aralkyl group, or an alkyl group having a terminal group containing a hydroxyl group, a carboxylic acid group, a sulfonic acid group, or a carboxylate group;
• a terminal group Z in formula II is selected from hydrogen, a C1-8 alkyl group, a C1-8 alkoxy group, a C3-8 cycloalkyl group, a phenyl group, a pyridyl group, a hydroxyl group, an amino group, a mercapto group, a carboxylic acid group, a carboxylate group, a sulfonic acid group, a sulfonate, a phosphoric acid group, a phosphate, an amino acid, triphenylphosphine, a quaternary ammonium salt, and a pyridine salt;
• when the terminal group Z in formula II is a quaternary ammonium salt, three substituents of the quaternary ammonium salt are respectively:
• a C1-8 alkyl group, a C2-8 alkenyl group, a C2-8 alkynyl group, a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, an aryl group, a C6-12 aralkyl group, or an alkyl group having a terminal group containing a hydroxyl group, a carboxylic acid group, a sulfonic acid group, or a carboxylate;
• and
• when the terminal group Z in formula II is a pyridine salt, a substituent on a pyridine ring of the pyridine salt is in an ortho-position, a meta-position, or a para-position, and the pyridine salt is obtained by quaternizing pyridine and halogenated hydrocarbons having 1 to 8 carbon atoms of different chain lengths.