# US 11,439,695 B2 · Kidney injury treatment

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- Number: US 11,439,695 B2
- Document ID: US11439695B2
- Status: Granted
- Kind: B2
- Application number: 17/151,027
- Filed: 2021-01-15
- Published: 2021-05-13
- Granted: 2022-09-13
- Earliest claimed: 2018-07-18
- Assignees: The Regents of the University of California; Fudan University
- Applicants: The Regents of the University of California; Fudan University
- Inventors: Keith E. Mostov; Liang Cai
- Web page: https://patentgrep.com/patent/US11439695B2

## CPC

- A61K 38/1709: {from mammals}
- A61K 38/57: from animals; from humans {(A61K38/553, A61K38/556 take precedence)}
- A61K 47/60: the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
- A61K 47/643: {Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]}
- A61K 47/68: the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61P 13/12: of the kidneys
- C07K 14/435: from animals; from humans
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

Methods and compositions for treating kidney injury are provided.

## Claims

### Claim 1

A method of treating acute kidney injury in a human, the method comprising administering to the human a sufficient amount of a polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO:1, to reduce at least one symptom of the acute kidney injury.

### Claim 2 (depends on 1)

The method of claim 1, wherein the polypeptide comprises SEQ ID NO:1.

### Claim 3 (depends on 1)

The method of claim 1, wherein the amino acid sequence is linked to a protein sequence that extends the circulating half-life in the blood of the polypeptide.

### Claim 4 (depends on 1)

The method of claim 1, wherein the amino acid sequence is linked to an antibody Fc domain or human serum albumin.

### Claim 5 (depends on 4)

The method of claim 4, wherein the amino acid sequence is linked to an antibody Fc domain that has been mutated to prolong the circulating half-life of polypeptide.

### Claim 6 (depends on 1)

The method of claim 1, wherein the polypeptide is PEGylated.

### Claim 7 (depends on 1)

The method of claim 1, wherein the polypeptide comprises at least one non-naturally-encoded amino acid.

### Claim 8 (depends on 1)

The method of claim 1, wherein the polypeptide is administered intravenously, orally, inhalationally, nasally, rectally, intraperitoneally, parenterally, intramuscularly, subcutaneously, or transdermally.