# US 11,439,690 B2 · Methods of treating spinal cord injury > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,439,690 B2 - Document ID: US11439690B2 - Status: Granted - Kind: B2 - Application number: 14/766,449 - Filed: 2014-02-06 - Published: 2015-12-31 - Granted: 2022-09-13 - Earliest claimed: 2013-02-07 - Assignees: The Cleveland Clinic Foundation - Applicants: The Cleveland Clinic Foundation - Inventors: Vinod Labhasetwar; Hayder H. Jaffer - Web page: https://patentgrep.com/patent/US11439690B2 ## CPC - A61K 38/446: {Superoxide dismutase (1.15)} - A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)} - A61K 9/19: lyophilised {, i.e. freeze-dried, solutions or dispersions (lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00)} - A61K 9/5153: {Polyesters, e.g. poly(lactide-co-glycolide)} - A61K 38/44: Oxidoreductases (1) - A61P 25/16: Anti-Parkinson drugs - A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia - C12Y 111/01006: Catalase (1.11.1.6) - C12Y 115/01001: Superoxide dismutase (1.15.1.1) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - C12Y: ENZYMES ## Abstract The invention is directed to a method of treating a spinal cord injury, a neurodegenerative disease or a neuronal injury in an individual in need thereof comprising administering an effective amount of superoxide dismutase (SOD) and catalase to the individual, wherein the superoxide dismutase and the catalase are encapsulated in one or more nanoparticles that release the SOD and catalase upon administration. Another aspect of the invention is directed to compositions comprising superoxide dismutase (SOD) and catalase encapsulated in one or more nanoparticles. ## Claims ### Claim 1 A method of treating a spinal cord injury in an individual in need thereof comprising: administering intravenously an effective amount of superoxide dismutase (SOD) and catalase to the individual in need thereof, wherein the superoxide dismutase and the catalase are encapsulated in one or more nanoparticles that localize at the spinal cord injury and release the SOD and the catalase upon administration, wherein the nanoparticles comprise poly (D,L-lactide co-glycolide) (PLGA) and polyvinyl alcohol; wherein the spinal cord injury is caused by a sudden fall, a vehicle accident, sports, or violence, and results in impact of mechanical force on the spinal cord that causes hemorrhage as a consequence of a primary injury and damages spinal cord tissue, and whereby the individual is treated for the spinal cord injury. ### Claim 2 (depends on 1) The method of claim 1, wherein the SOD and the catalase are encapsulated in separate nanoparticles. ### Claim 3 (depends on 1) The method of claim 1, wherein each of the nanoparticles comprise the SOD and the catalase. ### Claim 4 (depends on 1) The method of claim 1, wherein the SOD and the catalase are administered simultaneously to the individual. ### Claim 5 (depends on 1) The method of claim 1, wherein first the catalase is administered to the individual, then the SOD is administered to the individual. ### Claim 6 (depends on 1) The method of claim 1, wherein the one or more nanoparticles are biodegradable. ### Claim 7 (depends on 1) The method of claim 1, wherein each milligram of nanoparticles comprising the SOD is loaded with about 10 μg to about 150 μg SOD. ### Claim 8 (depends on 1) The method of claim 1, wherein each milligram of nanoparticles comprising the catalase is loaded with about 10 μg to about 150 μg catalase. ### Claim 9 (depends on 1) The method of claim 1, wherein after administration, some of the SOD and some of the catalase are released rapidly from the one or more nanoparticles, and then the SOD and the catalase that remains in the one or more nanoparticles is released slowly over a sustained period of time. ### Claim 10 (depends on 1) The method of claim 1 further comprising administering one or more cells, growth factors, tissue grafts, antioxidants, hormones, steroids, vitamins, minerals or a combination thereof to facilitate treatment of the spinal cord injury. ### Claim 11 (depends on 1) The method of claim 1, wherein the one or more nanoparticles are formulated as a lyophilized powder. ### Claim 12 (depends on 1) The method of claim 1, wherein the SOD and the catalase are administered upon or after removal of scar tissue from the spinal cord injury in the individual. ### Claim 13 (depends on 1) The method of claim 1, wherein the individual is a human. ### Claim 14 (depends on 1) The method of claim 1, wherein the spinal cord injury is caused by said sudden fall. ### Claim 15 (depends on 1) The method of claim 1, wherein the spinal cord injury is caused by said vehicle accident. ### Claim 16 (depends on 1) The method of claim 1, wherein the spinal cord injury is caused by said sports. ### Claim 17 (depends on 1) The method of claim 1, wherein the spinal cord injury is caused by said violence. ### Claim 18 (depends on 1) The method of claim 1, wherein said administering is performed by a paramedic.