# US 11,439,654 B2 · Topical analgesic

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- Number: US 11,439,654 B2
- Document ID: US11439654B2
- Status: Granted
- Kind: B2
- Application number: 17/467,629
- Filed: 2021-09-07
- Published: 2021-12-30
- Granted: 2022-09-13
- Earliest claimed: 2019-07-18
- Applicants: Concept Matrix Solutions
- Inventors: Tony LaRosa; Robert Davidson; David Reid
- Web page: https://patentgrep.com/patent/US11439654B2

## CPC

- A61K 31/7034: attached to a carbocyclic compound, e.g. phloridzin
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 31/045: Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K 31/522: having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol}
- A61K 36/3482: {Cannabis}
- A61K 36/76: Salicaceae (Willow family), e.g. poplar
- A61K 47/02: Inorganic compounds
- A61K 47/12: Carboxylic acids; Salts or anhydrides thereof
- A61K 47/22: Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A61K 47/24: containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61K 47/44: Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin (synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14)
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided herein is a topical analgesic composition that includes an external analgesic agent, one or more pharmaceutically acceptable excipients, and at least one of a cannabinoid, terpene, and flavonoid. Also provided is a method that includes topically administering to a skin surface of a subject (e.g., human) the topical analgesic composition.

## Claims

### Claim 1

A method for the temporary relief of aches or pains of affected muscles or joints areas, the method comprising topically administering to the affected areas of a subject in need thereof a topical analgesic comprising:
menthol, present in 2.5±0.5 wt. %;
cannabidiol (CBD), present in 0.33±0.07 wt. %;
carbopol, present in 1.4±0.3 wt. %;
lecithin, present in 2±0.4 wt. %;
caffeine anhydrous, present in 1.5±0.3 wt. %;
salicin, in an amount consisting of 1.25±0.25 wt. %;
organic hemp oil, present in 1±0.2 wt. %;
sodium benzoate, present in 0.1±0.02 wt. %,
tocopheryl acetate, present in 0.2±0.04 wt. %,
sodium bicarbonate, present in 1.5±0.3 wt. %; and
water, present in 88.22±5 wt. %;
wherein,
the topical analgesic is configured and formulated as a cream, lotion, or roll-on liquid.

### Claim 2 (depends on 1)

The method of claim 1, wherein the menthol is an external analgesic agent and is delivered to the skin or a localized region of the body.

### Claim 3 (depends on 1)

The method of claim 1, wherein the menthol is an external analgesic agent and is absorbed into the skin.

### Claim 4 (depends on 1)

The method of claim 1, wherein the aches or pains of affected muscles or joints areas are associated with at least one of: simple backache, sore muscles, muscle fatigue, muscle stiffness, joint stiffness, arthritis, muscle strains, bursitis, tendonitis, bruises, contusion, cramps, and sprain.

### Claim 5 (depends on 1)

The method of claim 1, wherein the topical analgesic is applied to at least one of the back, neck, shoulder, knee, elbow, foot, ankle, leg, arm, hand, and wrist of the subject and the method further comprises after topically administering the topical analgesic to the subject, rubbing or massaging the topical analgesic over the affected areas until thoroughly absorbed into the skin.

### Claim 6 (depends on 1)

The method of claim 1, wherein the cannabidiol (CBD) is present in 0.33±0.07 wt. %.

### Claim 7 (depends on 1)

The method of claim 1, wherein the cannabidiol (CBD) is obtained from cannabis as a CBD distillate, as a CBD isolate, or a combination thereof.

### Claim 8 (depends on 1)

The method of claim 1, wherein the lecithin is present in 2±0.4 wt. %.

### Claim 9 (depends on 1)

The method of claim 1, wherein the salicin is 98 wt. % pure.

### Claim 10 (depends on 1)

The method of claim 1, wherein the topical analgesic further comprises isopropyl alcohol.

### Claim 11 (depends on 1)

The method of claim 1, wherein the topical analgesic further comprises cannabigerol (CBG).

### Claim 12 (depends on 1)

The method of claim 1, wherein the topical analgesic is configured and formulated as a cream.

### Claim 13 (depends on 1)

The method of claim 1, wherein the topical analgesic is configured and formulated as a lotion.

### Claim 14 (depends on 1)

The method of claim 1, wherein the topical analgesic is configured and formulated as a roll-on liquid.

### Claim 15

A method for the temporary relief of aches or pains of affected muscles or joints areas, the method comprising topically administering to the affected areas of a subject in need thereof a topical analgesic comprising:
menthol, present in 2.5±0.5 wt. %;
cannabidiol (CBD), present in 0.33±0.07 wt. %;
carbopol, present in 1.4±0.3 wt. %;
lecithin, present in 2±0.4 wt. %;
caffeine anhydrous, present in 1.5±0.3 wt. %;
salicin, in an amount consisting of 1.25±0.25 wt. %;
organic hemp oil, present in 1±0.2 wt. %;
sodium benzoate, present in 0.1±0.02 wt. %;
tocopheryl acetate, present in 0.2±0.04 wt. %;
sodium bicarbonate, present in 1.5±0.3 wt. %;
water, present in 88.22±5 wt. %;
optionally cannabigerol (CBG);
optionally isopropyl alcohol;
wherein,
the topical analgesic is configured and formulated as a cream, lotion, or roll-on liquid;
and
the cannabidiol (CBD) is obtained from cannabis as a CBD distillate, a CBD isolate, or a combination thereof.