# US 11,439,618 B2 · Compositions and methods for lowering triglycerides

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- Number: US 11,439,618 B2
- Document ID: US11439618B2
- Status: Granted
- Kind: B2
- Application number: 17/148,449
- Filed: 2021-01-13
- Published: 2021-07-08
- Granted: 2022-09-13
- Earliest claimed: 2009-06-15
- Assignees: Amarin Pharmaceuticals Ireland Limited
- Applicants: Amarin Pharmaceuticals Ireland Limited
- Inventors: Ian Osterloh; Pierre Wicker; Rene Braeckman; Paresh Soni; Mehar Manku
- Web page: https://patentgrep.com/patent/US11439618B2

## CPC

- A61K 31/232: having three or more double bonds, e.g. etretinate
- A61K 9/48: Preparations in capsules, e.g. of gelatin, of chocolate {(A61K9/0004 takes precedence; bite capsules A61K9/0056)}
- A61K 31/202: having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557)
- A61K 31/366: having six-membered rings, e.g. delta-lactones
- A61K 31/40: having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K 31/505: Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00)
- A61P 3/06: Antihyperlipidemics
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 7/00: Drugs for disorders of the blood or the extracellular fluid
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/04: Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A61P 9/06: Antiarrhythmics
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 9/12: Antihypertensives
- C07C 57/03: Monocarboxylic acids
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.

## Claims

### Claim 1

A method of lowering triglycerides in a subject on stable statin therapy having type 2 diabetes mellitus and fasting triglycerides of about 200 mg/dl to about 500 mg/dl, the method comprising administering to the subject a composition comprising about 4 g of ethyl eicosapentaenoate per day for a period of time effective to reduce the fasting triglycerides in the subject wherein the composition comprises at least 96% by weight ethyl eicosapentanoate.

### Claim 2 (depends on 1)

The method of claim 1, wherein the subject has serum LDL-C levels of about 40 mg/dl to about 115 mg/dl.

### Claim 3 (depends on 1)

The method of claim 1, wherein the composition is administered to the subject 1 to 4 times per day.

### Claim 4 (depends on 3)

The method of claim 3, wherein the composition is present in one or more capsules.

### Claim 5 (depends on 1)

The method of claim 1, wherein the composition contains not more than about 10% by weight of docosahexaenoic acid or derivatives thereof.

### Claim 6 (depends on 1)

The method of claim 1, wherein the period is about 1 week to about 12 weeks.

### Claim 7 (depends on 1)

The method of claim 1, wherein the period is about 12 weeks.