# US 11,439,606 B2 · Reduction of hyperglycemia by administration of dimethylformamide for treating hyperglycemic conditions, including diabetes mellitus

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- Number: US 11,439,606 B2
- Document ID: US11439606B2
- Status: Granted
- Kind: B2
- Application number: 16/699,674
- Filed: 2019-12-01
- Published: 2020-06-04
- Granted: 2022-09-13
- Earliest claimed: 2018-12-03
- Assignees: Guadalupe Cleva Villanueva Lopez
- Applicants: Robert D. Kross; Guadalupe Cleva Villanueva Lopez
- Inventors: Robert D. Kross; Guadalupe Cleva Villanueva Lopez
- Web page: https://patentgrep.com/patent/US11439606B2

## CPC

- A61K 31/16: Amides, e.g. hydroxamic acids
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A treatment for a hyperglycemic condition, including diabetes mellitus, includes the step of administering to a human being dimethylformamide (“DMF”), which has the chemical structural formula: DMF can be administered to the human patient in a wide variety of ways, however it is preferable that the administration of DMF be performed orally and the dose of DMF could be combined with numerous inert substances known to the prior art, such as a sugarless fruit juice concentrate. The preferred daily dosage of DMF administered to a person would be about 0.041 mg/kg body weight to about 1.23 mg/kg of body weight of the person.

## Claims

### Claim 1

A method for treating a hyperglycemic condition, comprising the step of:
administering dimethylformamide to a patient thereby reducing a glycemic level of the patient by providing the patient with a daily dosage of approximately 0.041 mg/kg body weight to approximately 1.23 mg/kg of body weight of the patient.

### Claim 2 (depends on 1)

The method for treating a hyperglycemic condition, according to claim 1, wherein said step for administering dimethylformamide is performed by orally administering dimethylformamide to the patient.

### Claim 3 (depends on 2)

The method for treating a hyperglycemic condition, according to claim 2, further comprising the step of:
mixing dimethylformamide with an inert substance prior to said orally administering dimethylformamide to the patient.

### Claim 4 (depends on 3)

The method for treating a hyperglycemic condition, according to claim 3, wherein said inert substance is a sugarless fruit juice concentrate with dimethylformamide being dissolved in the sugarless fruit juice concentrate.

### Claim 5 (depends on 3)

The method for treating a hyperglycemic condition, according to claim 3, wherein said inert substance includes a sugar-free acidic liquid including an acid selected from the group consisting of citric acid, malic acid and a combination thereof, with dimethylformamide dissolved in the sugar-free acidic liquid.

### Claim 6

A method for treating a hyperglycemic condition, comprising the steps of:
mixing dimethylformamide with an inert substance, wherein said inert substance is a sugarless fruit juice concentrate with dimethylformamide being dissolved in the sugarless fruit juice concentrate; and,
orally administering dimethylformamide with said inert substance mixed therewith to a patient thereby reducing a glycemic level of the patient.

### Claim 7 (depends on 6)

The method for treating a hyperglycemic condition according to claim 6, wherein said inert substance includes a sugar-free acidic liquid including an acid selected from the group consisting of citric acid, malic acid and a combination thereof, with dimethylformamide dissolved in the sugar-free acidic liquid.