# US 11,439,601 B2 · Solid preparation composition for oral administration of colonic purgative containing anhydrous sodium sulfate, potassium sulfate, anhydrous magnesium sulfate and simethicone

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- Number: US 11,439,601 B2
- Document ID: US11439601B2
- Status: Granted
- Kind: B2
- Application number: 17/251,864
- Filed: 2019-05-27
- Published: 2021-08-19
- Granted: 2022-09-13
- Earliest claimed: 2018-06-18
- Assignees: Pharmbio Korea Co., Ltd.
- Applicants: Pharmbio Korea Co., Ltd.
- Inventors: Hyun Jung Jung; Zong Zhu Piao; Kyung Su Lee; Hwan Hyuk Lee
- Web page: https://patentgrep.com/patent/US11439601B2

## CPC

- A61K 9/2009: {Inorganic compounds}
- A61K 9/2853: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)}
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 9/2013: {Organic compounds, e.g. phospholipids, fats}
- A61K 9/2027: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates}
- A61K 9/2036: {Silicones; Polysiloxanes}
- A61K 9/2095: {Tabletting processes}
- A61K 31/695: Silicon compounds
- A61K 31/80: Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/04: Sulfur, selenium or tellurium; Compounds thereof
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61P 1/10: Laxatives
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a solid colonic purgative for oral application, containing anhydrous magnesium sulfate, potassium sulfate, anhydrous sodium sulfate, and, additionally, simethicone. The present invention is more satisfactory in the colon cleansing effect even with the doses reduced by up to about 20 percent compared to those of a conventional colonic purgative consisting of anhydrous magnesium sulfate, potassium sulfate and anhydrous sodium sulfate. Besides, the present invention, due to the reduced doses, has less unpleasant taste or odor caused by the main ingredients and requires a less intake of the preparation and water, improving drug compliance significantly. Further, unlike the conventional solid colonic purgative, the present invention can be prepared into tablets without using a water-soluble lubricant. In other words, the present invention can be formulated into a solid preparation for oral application by using a water-soluble lubricant, or even without using any water-soluble lubricant.

## Claims

### Claim 1

A tablet for oral application of a colonic purgative, consisting of anhydrous magnesium sulfate, potassium sulfate, anhydrous sodium sulfate, and simethicone, the tablet being manufactured into a preparation without adding a lubricant.

### Claim 2 (depends on 1)

The tablet according to claim 1, wherein water is added in an amount of 0.1 to 2.0 wt. % with respect to the total weight of an uncoated tablet in the manufacture of the tablet.

### Claim 3 (depends on 1)

The tablet for oral application according to claim 1, being manufactured by a direct tableting.