# US 11,439,583 B2 · Protective skin compositions

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- Number: US 11,439,583 B2
- Document ID: US11439583B2
- Status: Granted
- Kind: B2
- Application number: 15/501,782
- Filed: 2014-08-05
- Published: 2017-08-10
- Granted: 2022-09-13
- Earliest claimed: 2014-08-05
- Assignees: Amantin Experts
- Applicants: Amantin Experts
- Inventors: Elisabeth Briand; Jean-Baptiste Dumas Milne Edwards; Jacques Delort
- Web page: https://patentgrep.com/patent/US11439583B2

## CPC

- A61K 8/817: {Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)}
- A61K 8/0204: {Specific forms not provided for by any of groups A61K8/0208 - A61K8/14}
- A61K 8/19: containing inorganic ingredients
- A61K 8/73: Polysaccharides
- A61K 8/731: {Cellulose; Quaternized cellulose derivatives}
- A61K 8/733: {Alginic acid; Salts thereof}
- A61K 8/8147: {Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers}
- A61K 8/8158: {Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 31/731: Carrageenans
- A61K 31/734: Alginic acid
- A61K 31/78: of acrylic acid or derivatives thereof
- A61K 33/10: Carbonates; Bicarbonates
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/16: Emollients or protectives, e.g. against radiation
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61P 39/04: Chelating agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 17/00: Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A62D 5/00: Composition of materials for coverings or clothing affording protection against harmful chemical agents
- G21F 1/10: Organic substances; Dispersions in organic carriers
- G21F 3/02: Clothing
- A61K 2800/72: Hypo-allergenic
- A61K 2800/75: Anti-irritant
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A62D: CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING OR PROTECTING AGAINST HARMFUL CHEMICAL AGENTS; CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS
- G21F: PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR (radiation protection by pharmaceutical means A61K8/00, A61Q17/04; in cosmonautic vehicles B64G1/54; combined with a reactor G21C11/00; combined with X-ray tubes H01J35/16; combined with X-ray apparatus H05G1/02)

## Abstract

The subject of the present invention is cosmetic or pharmaceutical compositions which are protective against common skin irritants or allergens. The invention is also directed to the use of these compositions to protect skin from the effects of metal. Another object of the invention is a method of preventing or protecting the skin from the effects of metal, using the compositions of the invention.

## Claims

### Claim 1

A topical composition to protect skin against contact with metal irritants and allergens that comprises, at least one metal capturing agent bearing carboxyl moieties, and further comprising from 10% to 25% of the total weight of the composition of an agent chosen among zeolite, hydroxyapatite, calcium carbonate, calcium phosphate, ammonium calcium silicate, microporous aluminosilicate, sodium aluminosilicate, calcium silicate, sodium calcium aluminosilicate, and magnesium carbonates, tricalcium silicate, magnesium phosphate, manganese carbonate;
wherein the carboxyl bearing agent is a carbomer, present in an amount ranging from 0.1 to 10% of the total weight of the composition, and
wherein the topical composition has a pH of from 4 to 8.

### Claim 2 (depends on 1)

A topical composition according to claim 1, wherein the metal irritant or allergens is a metal cation.

### Claim 3 (depends on 1)

A topical composition according to claim 1, wherein the metal irritant or allergen is nickel, cobalt, chromium, zinc or lead.

### Claim 4 (depends on 1)

A topical composition according to claim 1, as a medicament.

### Claim 5 (depends on 1)

A topical composition according to claim 1 for its use to reduce or prevent contact dermatitis.

### Claim 6 (depends on 1)

A topical composition according to claim 1 for its use to prevent allergies to metals.

### Claim 7 (depends on 1)

A topical composition according to claim 1 for its use to reduce undesired effects on skin following to contact with irritating metals.

### Claim 8 (depends on 1)

A topical composition according to claim 1 for its use to limit risks induced by exposure to radioactive material.

### Claim 9 (depends on 8)

A topical composition according to claim 8, wherein the radioactive material is uranium.

### Claim 10 (depends on 1)

A topical composition according to claim 1, wherein the composition has a physiological pH.

### Claim 11 (depends on 1)

A topical composition according to claim 1, wherein the composition has a pH of from 5.5 to 6.9.