# US 11,439,577 B2 · Anti-aging or skin-regenerating composition comprising piperonylic acid as effective ingredient

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- Number: US 11,439,577 B2
- Document ID: US11439577B2
- Status: Granted
- Kind: B2
- Application number: 16/635,199
- Filed: 2018-07-23
- Published: 2021-04-08
- Granted: 2022-09-13
- Earliest claimed: 2017-08-02
- Assignees: Hesed Bio Co., Ltd.
- Applicants: Hesed Bio Co., Ltd.
- Inventors: Kyong Tai Kim; Dohyun Lee; Jinsun Lim
- Web page: https://patentgrep.com/patent/US11439577B2

## CPC

- A61K 8/4973: {with oxygen as the only hetero atom}
- A61P 17/00: Drugs for dermatological disorders
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 31/36: Compounds containing methylenedioxyphenyl groups, e.g. sesamin
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61Q 19/08: Anti-ageing preparations
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

The present invention relates to a pharmaceutical composition comprising piperonylic acid as an effective ingredient for anti-aging or regenerating the skin. A composition according to the present invention utilizes piperonylic acid that various plant species naturally contain therein and thus does not cause side effects. Piperonylic acid activates signals associated with cell survival, growth, and proliferation to exhibit the effect of increasing the resistance and survival of skin cells against external stimuli and enhancing the regeneration of the skin damaged due to external stimuli or senescence. In addition, piperonylic acid of the present invention has a similar function to EGF, but is stable and small in size in contrast to EGF. Thus, piperonylic acid of the present invention has the advantage of being able to easily move to the skin basal layer across the skin barrier and perform its function. Piperonylic acid of the present invention is expected to find applications in various fields including medicines, quasi-drugs, cosmetics, cosmetic substances, functional biomaterials, and functional food materials.

## Claims

### Claim 1

A method for anti-aging or regenerating the skin, the method comprising administering a pharmaceutically effective amount of piperonylic acid to an individual.

### Claim 2 (depends on 1)

The method of claim 1, wherein the piperonylic acid alleviates or treats skin wounds.

### Claim 3 (depends on 1)

The method of claim 1, wherein the piperonylic acid alleviates or treats burn wounds.

### Claim 4 (depends on 1)

The method of claim 1, wherein the piperonylic acid promotes the proliferation or growth of cells by binding to an epidermal growth factor receptor (EGFR).

### Claim 5 (depends on 4)

The method of claim 4, wherein the cells are keratinocytes.

### Claim 6 (depends on 1)

The method of claim 1, wherein the piperonylic acid enhances resistance to cell damage due to external stimuli.

### Claim 7 (depends on 6)

The method of claim 6, wherein the external stimuli is ultraviolet rays.

### Claim 8 (depends on 1)

The method of claim 1, wherein the piperonylic acid enhances skin elasticity.

### Claim 9 (depends on 1)

The method of claim 1, wherein the piperonylic acid alleviates skin wrinkles.