# US 11,439,532 B2 · Point of delivery cold slurry generation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,439,532 B2 - Document ID: US11439532B2 - Status: Granted - Kind: B2 - Application number: 15/946,410 - Filed: 2018-04-05 - Published: 2018-10-11 - Granted: 2022-09-13 - Earliest claimed: 2017-04-05 - Assignees: Miraki Innovation Think Tank LLC - Applicants: Miraki Innovation Think Tank LLC - Inventors: Christopher Velis - Web page: https://patentgrep.com/patent/US11439532B2 ## CPC - A61F 7/123: {using a flexible balloon containing the thermal element} - A61F 7/0085: {Devices for generating hot or cold treatment fluids} - A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)} - A61K 47/02: Inorganic compounds - A61P 41/00: Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution - A61F 2007/0057: {of gas, e.g. air or carbon dioxide} - A61F 2007/0095: {with a temperature indicator} - A61F 2007/126: {for invasive application, e.g. for introducing into blood vessels} - A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers - A61M 25/1011: {Multiple balloon catheters} - A61M 2025/1013: {with concentrically mounted balloons, e.g. being independently inflatable} - A61M 2025/105: {having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes} - A61M 2205/3368: Temperature - A61M 2205/3606: cooled - A61M 2205/362: by gas flow - A61M 2205/366: by liquid heat exchangers - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract The present invention provides methods and devices for making a cold slurry at a point of delivery. A point of delivery device delivers cold slurry components to a location at or near a target tissue. The components are combined to form the cold slurry at or near the point of delivery. This approach to generating a cold slurry at the point of delivery allows the characteristics of the cold slurry, such as temperature, particle shape and particle size, to be maintained and controlled. ## Claims ### Claim 1 A method of making a cold slurry at or near a target tissue underneath a subject's skin, the method comprising: delivering a first component to a target tissue underneath a subject's skin; delivering a second component to the target tissue; and forming a cold slurry at or near the target tissue from an interaction between the first component and the second component. ### Claim 2 (depends on 1) The method of claim 1, wherein the steps of delivering and the step of forming the cold slurry are carried out continuously. ### Claim 3 (depends on 1) The method of claim 1, wherein the first component is a liquid water and the second component is solid water. ### Claim 4 (depends on 3) The method of claim 3 further comprising breaking the solid water into particles of solid water at or near the target tissue. ### Claim 5 (depends on 3) The method of claim 3 further comprising forming the solid water by freezing liquid water at or near the target tissue. ### Claim 6 (depends on 1) The method of claim 1, wherein the first component is supercooled water and the second component is pellets of solid water; and wherein the interaction is crystal nucleation of the supercooled water caused by the pellets of solid water. ### Claim 7 (depends on 1) The method of claim 1, wherein the first component is liquid water contained in an inner balloon and the second component is a cooling fluid surrounding the inner balloon and contained within an outer balloon; and wherein the interaction is heat transferring from the liquid water to the cooling fluid. ### Claim 8 (depends on 7) The method of claim 7 further comprising puncturing the inner and outer balloons to release the cold slurry at or near the target tissue. ### Claim 9 A device for making a cold slurry at or near a target tissue underneath a subject's skin, the device comprising: a first cannula for delivering a first component to a target tissue underneath a subject's skin, the first cannula comprising a first open distal end and first longitudinal axis extending from the first open distal end; a second cannula for delivering a second component to the target tissue, the second cannula comprising a second open distal end and a second longitudinal axis extending from the second open distal end, the second longitudinal axis aligned with the first longitudinal axis; wherein the first open distal end is proximate to the second open distal end for forming a cold slurry at or near the target tissue from an interaction between the first component and the second component. ### Claim 10 (depends on 9) The device of claim 9, wherein the first component is liquid water and the second component is solid water. ### Claim 11 (depends on 10) The device of claim 10 further comprising a grinder disposed about the second open distal end to break the solid water into particles of solid water at or near the target tissue. ### Claim 12 (depends on 10) The device of claim 10 further comprising a vibrator disposed about the second open distal end to break the solid water into particles of solid water at or near the target tissue. ### Claim 13 (depends on 10) The device of claim 10 further comprising a third cannula extending along the second cannula for carrying a cooling gas to form the solid water from liquid water at or near the target tissue. ### Claim 14 (depends on 9) The device of claim 9, wherein the first component is supercooled water and the second component is pellets of solid water; and wherein the interaction is crystal nucleation of the supercooled water caused by the pellets of solid water. ### Claim 15 (depends on 9) The device of claim 9 further comprising: an inner balloon disposed around the first open distal end of the first cannula, the inner balloon comprising an outer surface and a volume in fluid communication with the first cannula to receive the first component; an outer balloon disposed around the second open distal end of the second cannula, the outer balloon comprising an inner surface and a volume in fluid communication with the second cannula to receive the second component; and wherein the outer surface of the inner balloon and the inner surface of the outer balloon form a space for the interaction between the first and second components to occur, and form the cold slurry inside the inner balloon. ### Claim 16 (depends on 15) The device of claim 15, wherein the first component is a mixture of water and glycerol; and wherein the second component is a cooling gas. ### Claim 17 (depends on 15) The device of claim 15 further comprising a puncture needle extending along the second cannula and movable between an extended position and a retracted position; and wherein the puncture needle in the extended position breaks the inner balloon and the outer balloon, and releases the cold slurry at or near the target tissue. ### Claim 18 (depends on 9) The device of claim 9 further comprising a temperature sensor extending beyond the first and second open distal ends to measure the temperature of the cold slurry made at or near the target tissue. ### Claim 19 (depends on 9) The device of claim 9, wherein the first and second cannulas each have a size and shape suitable for inserting through the subject's skin.