# US 11,439,494 B2 · Medical devices

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- Number: US 11,439,494 B2
- Document ID: US11439494B2
- Status: Granted
- Kind: B2
- Application number: 15/977,967
- Filed: 2018-05-11
- Published: 2018-11-15
- Granted: 2022-09-13
- Earliest claimed: 2017-05-12
- Assignees: MicroVention, Inc.
- Applicants: MicroVention, Inc.
- Inventors: Xinping Wu; Jodi Hong; Gregory M. Cruise
- Web page: https://patentgrep.com/patent/US11439494B2

## CPC

- A61F 2/06: Blood vessels
- A61F 2/0077: {Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence)}
- A61L 31/022: {Metals or alloys}
- A61L 31/10: Macromolecular materials
- A61L 31/14: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61F 2/82: Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07)
- A61L 31/08: Materials for coatings
- A61L 2400/18: Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).

## Claims

### Claim 1

A method of coating an implantable medical device, the method comprising:
activating a surface of the implantable medical device by silanization with a silane, wherein the silane includes a reactive group selected from an acrylate, methacrylate, aldehyde, epoxy, ester, or a combination thereof, and
coupling a polymer formed from a first acrylate monomer and a second monomer containing an amine, a carboxylic acid, or a hydroxyl group to the reactive group of the activated surface, wherein the first monomer is alkoxyalkyl (meth)acrylate, tetrahydrofurfuryl acrylate, or
wherein
R1 is hydrogen,
R2 is an alkylene group with 1 to 4 carbons, and
R3 is an alkyl group with 1 to 4 carbons.

### Claim 2 (depends on 1)

The method of claim 1 further comprising hydroxylation of the surface using oxygen plasma.

### Claim 3 (depends on 2)

The method of claim 2, wherein the oxygen plasma is applied by an oxygen flow of about 120 sccm, a power of about 500 watts, a pressure of about 400 mTorr, a time of about 5 minutes, or a combination thereof.

### Claim 4 (depends on 1)

The method of claim 1, wherein silanization occurs through reaction with a silane selected from:
or a combination thereof.

### Claim 5 (depends on 4)

The method of claim 4, wherein n is 8-12.

### Claim 6 (depends on 1)

The method of claim 1 further comprising argon plasma treatment after silanization.

### Claim 7 (depends on 6)

The method of claim 6, wherein the argon plasma is applied by an argon flow of about 365 sccm, a power of about 300 watts, a pressure of about 500 mTorr, a time of about 10 minutes, or a combination thereof.

### Claim 8 (depends on 1)

The method of claim 1, wherein the coupling is by dip coating, spraying, brushing, or a combination thereof.

### Claim 9 (depends on 1)

The method of claim 1, wherein the first monomer is tetrahydrofurfuryl acrylate.

### Claim 10 (depends on 1)

The method of claim 1, wherein the second monomer is acrylic acid, methacrylic acid, hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxybutyl acrylate, aminoethyl methacrylate, aminopropyl methacrylamide, a combination thereof.

### Claim 11 (depends on 1)

The method of claim 1, wherein the silane includes an epoxy reactive group.

### Claim 12 (depends on 1)

The method of claim 1, wherein the first monomer is alkoxyalkyl (meth)acrylate.

### Claim 13 (depends on 1)

The method of claim 1, wherein silanization occurs through reaction with a silane selected from:
or a combination thereof.

### Claim 14 (depends on 1)

The method of claim 1, wherein the second monomer is hydroxybutyl acrylate, aminopropyl methacrylamide, or a combination thereof.

### Claim 15 (depends on 1)

The method of claim 1, wherein the first monomer is methoxyethyl acrylate.