# US 11,439,468 B2 · Fluorescent imaging device

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- Number: US 11,439,468 B2
- Document ID: US11439468B2
- Status: Granted
- Kind: B2
- Application number: 16/270,758
- Filed: 2019-02-08
- Published: 2019-08-15
- Granted: 2022-09-13
- Earliest claimed: 2018-02-09
- Assignees: Shimadzu Corporation
- Applicants: Shimadzu Corporation
- Inventors: Tatsuya Ikehara
- Web page: https://patentgrep.com/patent/US11439468B2

## CPC

- A61B 34/20: Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B 1/00045: {Display arrangement}
- A61B 1/00096: {Optical elements}
- A61B 1/043: {for fluorescence imaging}
- A61B 1/0638: {providing two or more wavelengths}
- A61B 1/0653: {with wavelength conversion}
- A61B 5/0071: {by measuring fluorescence emission}
- A61B 5/1128: {using image analysis (A61B5/1127 takes precedence)}
- A61B 5/14556: {by fluorescence (A61B5/14555 takes precedence)}
- A61B 5/7425: {Displaying combinations of multiple images regardless of image source, e.g. displaying a reference anatomical image with a live image}
- G06T 7/248: {involving reference images or patches}
- A61B 5/0033: {Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room}
- A61B 2034/2057: {Details of tracking cameras}
- G06T 2207/10048: Infrared image
- G06T 2207/10064: Fluorescence image
- G06T 2207/30048: Heart; Cardiac
- G06T 2207/30104: Vascular flow; Blood flow; Perfusion
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL

## Abstract

A fluorescent imaging device includes a light source unit including a first light source for radiating excitation light, a second light source for radiating visible illumination light, and a third light source for radiating non-visible light, an imager being configured to capture a fluorescent image, a visible image, and a non-visible image, and a tracking processor that is operable to perform moving-body tracking for a region of interest that is set in an image based on at least the non-visible image.

## Claims

### Claim 1

A fluorescent imaging device comprising:
a light source unit including a first light source for radiating excitation light for a fluorescent agent administered to a subject, a second light source for radiating visible illumination light in a visible wavelength range, and a third light source for radiating non-visible light outside the visible wavelength range;
an imager including an optical filter, the optical filter being configured to separate light in the visible wavelength range from both fluorescence outside the visible wavelength range excited by the excitation light and the non-visible light, the imager being configured to capture a fluorescent image based on the fluorescence, a visible image based on reflected light of the visible illumination light, and a non-visible image based on reflected light of the non-visible light; and
a tracking processor that is operable to perform moving-body tracking for a region of interest that is set in an image based on at least the non-visible image.

### Claim 2 (depends on 1)

The fluorescent imaging device according to claim 1, wherein the tracking processor is operable to perform the moving-body tracking for the region of interest based on the fluorescent image in addition to the non-visible image.

### Claim 3 (depends on 1)

The fluorescent imaging device according to claim 1, wherein the tracking processor is operable to perform the moving-body tracking for the region of interest based on the non-visible image before administration of the fluorescent agent to the subject, and is operable to perform the moving-body tracking for the region of interest based on the non-visible image or the fluorescent image after the administration of the fluorescent agent.

### Claim 4 (depends on 3)

The fluorescent imaging device according to claim 3, wherein the tracking processor is operable to use the non-visible image as an image used for the moving-body tracking at least before the administration of the fluorescent agent and is operable to switch the image used for the moving-body tracking to the fluorescent image based on a pixel value.

### Claim 5 (depends on 1)

The fluorescent imaging device according to claim 1, further comprising a selector for selecting an image that is used for the moving-body tracking, the image being one of the fluorescent image, the non-visible image, and the visible image.

### Claim 6 (depends on 5)

The fluorescent imaging device according to claim 5, wherein the selector is operable to switch the image used for the moving-body tracking from the fluorescent image, the visible image, or the non-visible image during the moving-body tracking by the tracking processor.

### Claim 7 (depends on 1)

The fluorescent imaging device according to claim 1, further comprising an analysis processor for analyzing flow of the fluorescent agent that is to pass through the region of interest in the fluorescent image based on the result of the moving-body tracking.

### Claim 8 (depends on 7)

The fluorescent imaging device according to claim 7, wherein the analysis processor is operable to generate a time intensity curve of the fluorescence generated as a result of the flow of the fluorescent agent through the region of interest in the fluorescent image.

### Claim 9 (depends on 1)

The fluorescent imaging device according to claim 1, wherein the third light source is configured to radiate the non-visible light in a near-infrared wavelength range.

### Claim 10 (depends on 1)

The fluorescent imaging device according to claim 1, wherein
the third light source is configured to radiate the non-visible light in a wavelength range that overlaps with a wavelength of the fluorescence, and
the imager includes a first imaging element for capturing the fluorescent image and the non-visible image and a second imaging element for capturing the visible image.

### Claim 11 (depends on 1)

The fluorescent imaging device according to claim 1, wherein the third light source is configured to radiate the non-visible light, which substantially excludes a wavelength range of light of a fluorescent lamp.

### Claim 12 (depends on 1)

The fluorescent imaging device according to claim 1, wherein the tracking processor is operable to perform the moving-body tracking of the region of interest via template matching performed between an image portion contained in an image and a template image.

### Claim 13 (depends on 12)

The fluorescent imaging device according to claim 12, wherein the tracking processor is operable to perform processing of updating the template image with a captured image.

### Claim 14 (depends on 1)

The fluorescent imaging device according to claim 1, wherein
the imager is configured to capture the fluorescent image, the visible image, and the non-visible image in the same field of view, and
the tracking processor is operable to perform the moving-body tracking of the region of interest of at least the non-visible image at the same position as that of the region of interest received on the visible image.

### Claim 15 (depends on 1)

The fluorescent imaging device according to claim 1, further comprising an endoscopic device in which the light source unit and the imager are provided.