# US 11,439,404 B2 · Indwelling device for embolization and method for manufacturing the same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,439,404 B2 - Document ID: US11439404B2 - Status: Granted - Kind: B2 - Application number: 16/642,249 - Filed: 2018-07-27 - Published: 2020-11-12 - Granted: 2022-09-13 - Earliest claimed: 2017-09-12 - Assignees: Kaneka Corporation - Applicants: Kaneka Corporation - Inventors: Qian Wu - Web page: https://patentgrep.com/patent/US11439404B2 ## CPC - A61B 17/12154: {having stretch limiting means} - A61B 17/12113: {within an aneurysm} - A61B 2017/00526: {Methods of manufacturing} - A61B 2017/00867: {shape memory effect} - A61B 2017/1205: {Introduction devices} - A61B 2017/12068: {detachable by heat} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract An indwelling device for embolization comprises a coil portion (11) having a proximal side and a distal side and having a lumen extending in a longitudinal direction, a stretch-resistant member (20) disposed in the lumen, wherein the indwelling device has a fixing structure in which the stretch-resistant member (20) is knotted to the detachable portion attached in the lumen of a proximal end part of the coil portion (11) and extending proximally from a proximal end of the lumen, in order for the stretch-resistant member (20) to be more securely anchored to the coil portion (11). ## Claims ### Claim 1 An indwelling device for embolization comprising; a coil portion having a proximal end and a distal end and having a lumen extending in a longitudinal direction; a stretch-resistant member disposed in the lumen and extending from the proximal end part to the distal end part of the coil portion; a rod-shaped detachable portion having a rod part extending in the longitudinal direction, an end part of the rod-shaped detachable portion disposed in the lumen of the proximal end part of the coil portion so that another end part of the rod-shaped detachable portion proximally extends from the proximal end part of the coil portion, and a fixing structure including a knot in which the stretch-resistant member is knotted to the rod part of the detachable portion, the knot disposed on the rod part of the detachable portion. ### Claim 2 (depends on 1) The indwelling device for embolization according to claim 1, wherein an insulating portion is disposed on the detachable portion and proximal to the fixing structure. ### Claim 3 (depends on 1) The indwelling device for embolization according to claim 1, wherein the coil portions has a small diameter portion at a proximal end part, the small diameter portion has an inner diameter, which is smaller than an inner diameter of a distal part of the coil portion. ### Claim 4 (depends on 1) The indwelling device for embolization according to claim 1, wherein the knot is at least one half-knot disposed proximal to a proximal end of the lumen of the coil portion. ### Claim 5 (depends on 1) The indwelling device for embolization according to claim 1, wherein the knot is a plurality of half-knots located at different positions on the detachable portion. ### Claim 6 (depends on 1) The indwelling device for embolization according to claim 1, wherein the stretch-resistant member is folded in a two-folded state at a distal part of the coil portion. ### Claim 7 (depends on 1) The indwelling device for embolization according to claim 1, wherein the fixing structure includes a cured adhesive attached to a portion where the stretch-resistant member is knotted to the detachable portion, and an adhesive to form the cured adhesive is selected from a group consisting of an ultraviolet curable adhesive, a thermosetting adhesive and a moisture curable adhesive each having a viscosity of 10 mPa·s to 2000 mPa·s. ### Claim 8 (depends on 7) The indwelling device for embolization according to claim 7, wherein the cured adhesive is disposed to extend from a proximal part of the coil portion to a distal part of the detachable portion. ### Claim 9 (depends on 1) The indwelling device for embolization according to claim 1, wherein the knot of the stretch-resistant member is disposed out of the lumen of the coil portion. ### Claim 10 (depends on 1) The indwelling device for embolization according to claim 1, wherein the detachable portion comprises a heat-melt material. ### Claim 11 (depends on 1) The indwelling device for embolization according to claim 1, further comprises a pusher portion, wherein the coil portion, the detachable portion and the pusher portion are disposed in this order from a distal side of the indwelling device, and the coil portion and the pusher portion are connected to each other via the detachable portion. ### Claim 12 (depends on 1) The indwelling device for embolization according to claim 1, wherein the stretch-resistant member is a linear member, and one end of the stretch-resistant member is fixed at a distal portion of the coil portion, and another end of the stretch-resistant member is knotted to the detachable portion. ### Claim 13 (depends on 1) The indwelling device for embolization according to claim 1, wherein a distal end of the detachable portion is disposed inside the coil portion, and the knot of the stretch-resistant member is disposed out of the lumen of the coil portion. ### Claim 14 A method for manufacturing an indwelling device for embolization comprising: disposing a stretch-resistant member inside a coil portion which extends in a longitudinal direction; inserting a detachable portion into a proximal end part of the coil portion, wherein the detachable portion has a rod part extending in the longitudinal direction; forming a fixing structure by knotting the stretch-resistant member to the rod part of the detachable portion to fix the stretch-resistant member to the detachable portion, whereby a knot is formed on the rod part of the detachable portion; applying an adhesive to the fixing structure; and curing the adhesive. ### Claim 15 (depends on 14) The method for manufacturing an indwelling device for embolization according to claim 14, further comprising reducing an inner diameter of a proximal end of the coil portion after the step of disposing the stretch-resistant member inside the coil portion. ### Claim 16 (depends on 14) The method for manufacturing an indwelling device for embolization according to claim 14, wherein the knot is at least one half-knot disposed proximal to a proximal end of the lumen of the coil portion. ### Claim 17 (depends on 14) The method for manufacturing an indwelling device for embolization according to claim 14, wherein the knot of the stretch-resistant member is disposed out of the lumen of the coil portion. ### Claim 18 (depends on 14) The method for manufacturing an indwelling device for embolization according to claim 14, wherein a distal end of the detachable portion is disposed inside the coil portion, and the knot of the stretch-resistant member is disposed out of the lumen of the coil portion.