# US 11,439,374 B2 · Devices and methods for endoscopic patch delivery

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,439,374 B2
- Document ID: US11439374B2
- Status: Granted
- Kind: B2
- Application number: 16/525,888
- Filed: 2019-07-30
- Published: 2020-02-06
- Granted: 2022-09-13
- Earliest claimed: 2018-07-31
- Assignees: Boston Scientific Scimed, Inc.
- Applicants: Boston Scientific Scimed, Inc.
- Inventors: Amanda Smith; Andrew Pic; Hannah Rebar
- Web page: https://patentgrep.com/patent/US11439374B2

## CPC

- A61B 17/00234: {for minimally invasive surgery (A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence)}
- A61B 17/0057: {Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect (sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009)}
- A61L 24/0005: {Ingredients of undetermined constitution or reaction products thereof}
- A61L 24/08: Polysaccharides {(A61L24/043 takes precedence)}
- A61B 2017/00269: {endoscopic mucosal resection EMR}
- A61B 2017/00296: {mounted on an endoscope}
- A61B 2017/00323: {Cables or rods}
- A61B 2017/0034: {adapted to be inserted through a working channel of an endoscope}
- A61B 2017/00477: {Coupling (A61B2017/0046 takes precedence)}
- A61B 2017/00557: {inflatable (A61B2017/22051 takes precedence)}
- A61B 2017/0061: {Implements located only on one side of the opening}
- A61B 2017/00623: {Introducing or retrieving devices therefor}
- A61B 2017/00902: {transparent or translucent}
- A61B 2217/005: with suction drainage system
- A61B 2217/007: with irrigation system
- A61F 2/0063: {Implantable repair or support meshes, e.g. hernia meshes}
- A61F 2/04: Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts (A61F2/18, A61F2/20 take precedence; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95)
- A61F 2002/0072: {Delivery tools therefor}
- A61F 2002/044: {Oesophagi or esophagi or gullets}
- A61F 2002/045: {Stomach, intestines}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

Systems and methods of delivering a patch to a target site of a patient are described herein. The patch may comprise a biomaterial such as chitosan or extracellular matrix and may be biocompatible and/or bioresorbable. The system may include an endoscope, a patch, and one of an instrument or a cap, the patch being coupled to the respective instrument or cap and detachable therefrom. Methods of delivering the patch to the target site may include introducing an endoscope into a gastrointestinal tract of a patient, e.g., the patch being in a folded or crimped configuration, navigating a distal end of the endoscope proximate a target site; and applying the patch to the target site while releasing the patch from the endoscope.

## Claims

### Claim 1

A method of delivering a patch to a target site of a patient, the method comprising:
introducing an endoscope into a gastrointestinal tract of a patient, wherein the endoscope includes a patch in a folded or crimped configuration, the patch comprising a biocompatible material;
positioning a distal end of the endoscope proximate a target site; and
applying the patch to the target site while releasing the patch from the endoscope;
wherein the target site includes a laceration in tissue following endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or tissue biopsy; or wherein the target site includes an anastomosis;
wherein the endoscope includes a cap coupled to the distal end of the endoscope, the patch covering a distal end of the cap and being releasable from the cap;
wherein the patch is secured to an outer surface of the cap with a flexible band; and
wherein releasing the patch from the cap includes actuating a wire to cut the flexible band from the cap.

### Claim 2 (depends on 1)

The method of claim 1, wherein the patch comprises chitosan, extracellular matrix, or a combination thereof.

### Claim 3 (depends on 1)

The method of claim 1, wherein the cap has a frustoconical shape and a ridge on an outer surface of the cap.

### Claim 4 (depends on 1)

The method of claim 1, wherein the distal end of the endoscope includes an optical device, and the patch includes an opening aligned with the optical device.

### Claim 5 (depends on 1)

The method of claim 1, wherein the cap is fixedly coupled to the distal end of the endoscope.

### Claim 6 (depends on 1)

The method of claim 1, wherein releasing the patch from the cap includes applying pressure to the patch with the endoscope.

### Claim 7

A method of delivering a patch to a target site of a patient, the method comprising:
introducing a system comprising an endoscope into a gastrointestinal tract of a patient, wherein the system includes a patch comprising a biocompatible material and
a cap fixedly coupled to a distal end of the endoscope, wherein the patch is secured to an outer surface of the cap with a flexible band, covers a distal opening of the cap, and is releasable from the cap;
positioning a distal end of the endoscope proximate a target site; and
applying the patch to the target site while releasing the patch from cap;
wherein releasing the patch from the cap includes actuating a wire to release the flexible band.

### Claim 8 (depends on 7)

The method of claim 7, wherein applying the patch includes blowing air or spraying water from a channel of the endoscope onto the patch.

### Claim 9 (depends on 7)

The method of claim 7, wherein releasing the patch from the cap includes actuating the wire to cut the flexible band, and a portion of the flexible band remains tethered to the cap after the flexible band is cut.

### Claim 10

A medical system comprising:
an endoscope defining at least one working channel;
a patch comprising a biocompatible material; and
a cap coupled to a distal end of the endoscope, the patch covering a distal end of the cap and being releasable from the cap;
wherein the patch is secured to an outer surface of the cap with a flexible band;
wherein a wire extending through the at least one working channel is coupled to the flexible band;
wherein the distal end of the endoscope includes an optical device, and the patch includes an opening aligned with the optical device.