# US 11,439,341 B2 · Diffusion imaging in Parkinson's disease and Parkinsonism > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,439,341 B2 - Document ID: US11439341B2 - Status: Granted - Kind: B2 - Application number: 16/904,750 - Filed: 2020-06-18 - Published: 2020-10-08 - Granted: 2022-09-13 - Earliest claimed: 2017-04-18 - Assignees: University of Florida Research Foundation, Inc. - Applicants: University of Florida Research Foundation, Incorporated - Inventors: David E. Vaillancourt - Web page: https://patentgrep.com/patent/US11439341B2 ## CPC - A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging - A61B 5/4082: {Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette} - A61B 5/4848: {Monitoring or testing the effects of treatment, e.g. of medication} - A61B 2576/026: for the brain - G16H 30/40: for processing medical images, e.g. editing - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract A treatment efficacy of a treatment for treating a parkinsonian disease is determined. A first set of imaging information/data associated with a dMRI scan of an individual's brain captured at a first time and a second set of imaging information/data associated with a dMRI scan of the individual's brain captured at a second time are received. The individual underwent the treatment for a time period comprising at least part of the time between the first and second times. An expected change between the first and second times is determined based on a natural progression of the parkinsonian disease. The first and second sets of imaging information/data are analyzed to determine a first free-water pattern and a second free-water pattern. Based on the first and second free-water patterns, a disease progression score is determined. Based on the disease progression score and the expected change, a treatment efficacy for treating the individual with the treatment is determined. ## Claims ### Claim 1 A method for determining a free-water pattern of an individual, the method comprising: receiving, at a computing entity, an instance of imaging information/data associated with a dMRI scan of an individual's brain; and using, by the computing entity, at least one linear registration followed by at least one non-linear warping and at least one of (a) a free-water pattern template or (b) 2D or 3D threshold requirements to determine a free-water pattern for one or more areas of the individual's brain based at least in part on a portion of the instance of imaging data, wherein the free-water pattern is used to determine the individual's parkinsonian state, and wherein the at least one linear registration comprises: b0 registration to a mean b0 template; fractional anisotropy (FA) registration to a mean FA template; and FA*b0 registration to a mean FA*b0 template. ### Claim 2 (depends on 1) The method of claim 1, wherein the free-water pattern comprises a free-water fraction of the one or more areas of the individual's brain and the one or more areas of the individual's brain comprise one or more of the anterior substantia nigra, posterior substantia nigra, putamen, caudate nucleus, globus pallidus, subthalamic nucleus, middle cerebellar peduncle, superior cerebellar peduncle, cerebellar lobule VI, inferior vermis, pedunculopontine nucleus, or hippocampus. ### Claim 3 (depends on 1) The method of claim 1, wherein a type of parkinsonian disease is determined based at least in part on the free-water pattern. ### Claim 4 (depends on 1) The method of claim 1, wherein the one or more areas of the individual's brain are automatically identified by the computing entity. ### Claim 5 (depends on 1) The method of claim 1, wherein at least one of the (a) free-water pattern template or (b) 2D or 3D threshold requirements is generated using an automated normalization pipeline. ### Claim 6 An apparatus comprising at least one processor, a communications interface configured for communicating via at least one network, and at least one memory storing computer program code, the at least one memory and the computer program code configured to, with the processor, cause the apparatus to at least: receive an instance of imaging information/data associated with a dMRI scan of an individual's brain; and use at least one linear registration followed by at least one non-linear registration and at least one of (a) a free-water pattern template or (b) 2D or 3D threshold requirements to determine a free-water pattern for one or more areas of the individual's brain based at least in part on a portion of the instance of imaging data, wherein the free-water pattern is used to determine the individual's parkinsonian state, and wherein the at least one linear registration comprises: b0 registration to a mean b0 template; fractional anisotropy (FA) registration to a mean FA template; and FA*b0 registration to a mean FA*b0 template. ### Claim 7 (depends on 6) The apparatus of claim 6, wherein the free-water pattern comprises a free-water fraction of the one or more areas of the individual's brain and the one or more areas of the individual's brain comprise one or more of the anterior substantia nigra, posterior substantia nigra, putamen, caudate nucleus, globus pallidus, subthalamic nucleus, middle cerebellar peduncle, superior cerebellar peduncle, cerebellar lobule VI, inferior vermis, pedunculopontine nucleus, or hippocampus. ### Claim 8 (depends on 6) The apparatus of claim 6, wherein a type of parkinsonian disease is determined based at least in part on the free-water pattern. ### Claim 9 (depends on 6) The apparatus of claim 6, wherein the one or more areas of the individual's brain are automatically identified by the computing entity. ### Claim 10 (depends on 6) The apparatus of claim 6, wherein at least one of the (a) free-water pattern template or (b) 2D or 3D threshold requirements is generated using an automated normalization pipeline. ### Claim 11 A computer program product comprising at least one non-transitory computer-readable storage medium having computer-readable program code portions stored therein, the computer-readable program code portions comprising executable portions configured, when executed by a processor of an apparatus, to cause the apparatus to: receive an instance of imaging information/data associated with a dMRI scan of an individual's brain; and use at least one linear registration followed by at least one non-linear registration and at least one of (a) a free-water pattern template or (b) 2D or 3D threshold requirements to determine a free-water pattern for one or more areas of the individual's brain based at least in part on a portion of the instance of imaging data, wherein the free-water pattern is used to determine the individual's parkinsonian state, and wherein the at least one linear registration comprises: b0 registration to a mean b0 template; fractional anisotropy (FA) registration to a mean FA template; and FA*b0 registration to a mean FA*b0 template. ### Claim 12 (depends on 11) The computer program product of claim 11, wherein the free-water pattern comprises a free-water fraction of the one or more areas of the individual's brain and the one or more areas of the individual's brain comprise one or more of the anterior substantia nigra, posterior substantia nigra, putamen, caudate nucleus, globus pallidus, subthalamic nucleus, middle cerebellar peduncle, superior cerebellar peduncle, cerebellar lobule VI, inferior vermis, or pedunculopontine nucleus, hippocampus. ### Claim 13 (depends on 11) The computer program product of claim 11, wherein a type of parkinsonian disease is determined based at least in part on the free-water pattern. ### Claim 14 (depends on 11) The computer program product of claim 11, wherein the one or more areas of the individual's brain are automatically identified by the computing entity. ### Claim 15 (depends on 11) The computer program product of claim 11, wherein at least one of the (a) free-water pattern template or (b) 2D or 3D threshold requirements is generated using an automated normalization pipeline.