# US 11,439,339 B1 · Method and system for measuring cardiac tissue health based on DV/DTmin of a depolarization wave within a cardiac electrogram

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- Number: US 11,439,339 B1
- Document ID: US11439339B1
- Status: Granted
- Kind: B1
- Application number: 17/073,230
- Filed: 2020-10-16
- Granted: 2022-09-13
- Earliest claimed: 2020-10-16
- Assignees: Neucures Inc.
- Applicants: Neucures Inc.
- Inventors: Robert L. Lux
- Web page: https://patentgrep.com/patent/US11439339B1

## CPC

- A61B 5/349: Detecting specific parameters of the electrocardiograph cycle
- A61B 5/367: Electrophysiological study [EPS], e.g. electrical activation mapping or electro-anatomical mapping
- A61B 5/346: Analysis of electrocardiograms
- A61B 5/062: {using magnetic field}
- A61B 5/283: Invasive
- A61B 5/7203: {for noise prevention, reduction or removal}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A method for determining cardiac tissue health based on a depolarization wave within an EGM is disclosed. The method includes computing a first derivative with respect to time (DV/DT) of the EGM, determining extrema for the first derivative, establishing a value DV/DTMIN based on the extrema and mapping the value DV/DTMIN to cardiac tissue.

## Claims

### Claim 1

A method for determining cardiac tissue health based on a depolarization wave within an electrogram (EGM), comprising:
receiving, by a processor, an electrogram (EGM), wherein the EGM comprises at least one of a unipolar EGM and a bipolar EGM;
removing, by the processor, noise from the EGM when the noise is above a predefined threshold;
computing, by the processor, a first derivative with respect to time (DV/DT) of the EGM;
determining, by the processor, extrema for the first derivative, wherein the extrema comprises at least a maxima and a minima;
based on the extrema, establishing, by the processor, a value DV/DTMIN by selecting at least one of
the minima as the value for DV/DTMIN for the unipolar EGM;
the maxima and the minima for the bipolar EGM as the value for DV/DTMIN based on a ratio; and
mapping, by the processor, the value DV/DTMIN to cardiac tissue.

### Claim 2 (depends on 1)

The method of claim 1, wherein the value for DV/DTMIN for the bipolar EGM is selected as Min dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is greater than or equal to one.

### Claim 3 (depends on 1)

The method of claim 1, wherein the value for DV/DTMIN for the bipolar EGM is selected as the −Max dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is less than one.

### Claim 4 (depends on 1)

The method of claim 1, wherein the noise is removed by applying a power line filter or a random noise filter to the EGM.

### Claim 5

A system for determining cardiac tissue health based on a depolarization wave within an electrogram (EGM), comprising:
a memory; and
one or more processors coupled to the memory programmed with executable instructions to:
receive an electrogram (EGM), wherein the EGM comprises at least one of a unipolar EGM and a bipolar EGM;
remove noise from the EGM when the noise is above a predefined threshold;
compute a first derivative with respect to time (DV/DT) of the EGM;
determine extrema for the first derivative, wherein the extrema comprise at least a maxima and a minima;
based on the extrema, establish a value DV/DTMIN by selecting at least one of
the minima as the value for DV/DTMIN for the unipolar EGM;
the maxima and the minima for the bipolar EGM as the value for DV/DTMIN based on a ratio; and
map the value DV/DTMIN to cardiac tissue.

### Claim 6 (depends on 5)

The system of claim 5, wherein the value for DV/DTMIN for the bipolar EGM is selected as Min dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is greater than or equal to one.

### Claim 7 (depends on 5)

The system of claim 5, wherein the value for DV/DTMIN for the bipolar EGM is selected as the −Max dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is less than one.

### Claim 8 (depends on 5)

The system of claim 5, wherein the noise is removed by applying a power line filter or a random noise filter to the EGM.

### Claim 9

A non-transitory computer readable storage medium, having stored thereon, a set of computer-executable instructions that causes a computer to perform the method comprising:
receiving an electrogram (EGM), wherein the EGM comprises at least one of a unipolar EGM and a bipolar EGM;
removing noise from the EGM when the noise is above a predefined threshold;
computing a first derivative with respect to time (DV/DT) of the EGM;
determining extrema for the first derivative, wherein the extrema comprise at least a maxima and a minima;
based on the extrema, establishing a value DV/DTMIN by selecting at least one of
the minima as the value for DV/DTMIN for the unipolar EGM;
the maxima and the minima for the bipolar EGM as the value for DV/DTMIN based on a ratio; and
mapping the value DV/DTMIN to cardiac tissue.

### Claim 10 (depends on 9)

The non-transitory computer readable storage medium of claim 9, wherein the value for DV/DTMIN for the bipolar EGM is selected as Min dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is greater than or equal to one.

### Claim 11 (depends on 9)

The non-transitory computer readable storage medium of claim 9, wherein the value for DV/DTMIN for the bipolar EGM is selected as the −Max dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is less than one.

### Claim 12 (depends on 9)

The non-transitory computer readable storage medium of claim 9, wherein the noise is removed by applying a power line filter or a random noise filter to the EGM.