# US 11,439,336 B2 · Biological information measurement system and recording medium > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,439,336 B2 - Document ID: US11439336B2 - Status: Granted - Kind: B2 - Application number: 16/589,695 - Filed: 2019-10-01 - Published: 2020-04-02 - Granted: 2022-09-13 - Earliest claimed: 2019-10-01 - Assignees: Ricoh Company, Ltd. - Applicants: Yoshihiro Misaka; Hirofumi Morise; Kiwamu Kudo - Inventors: Yoshihiro Misaka; Hirofumi Morise; Kiwamu Kudo - Web page: https://patentgrep.com/patent/US11439336B2 ## CPC - A61B 5/064: {using markers (A61B5/062 takes precedence)} - A61B 5/245: specially adapted for magnetoencephalographic [MEG] signals - A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging - A61B 5/291: for electroencephalography [EEG] - A61B 5/6803: {Head-worn items, e.g. helmets, masks, headphones or goggles} - A61B 5/70: {Means for positioning the patient in relation to the detecting, measuring or recording means} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A biological information measurement system includes a dewar, a single imaging device, and a hardware processor. The dewar covers a head of a subject and contains sensors that are arranged for detecting biological signals. The single imaging device acquires an image in which three or more reference points and the dewar are captured, the reference points being set in relation to the subject. The hardware processor is configured to: measure brain neural activity of the subject based on the biological signals detected by the sensors; determine positional relationships between the reference points of the subject and the sensors based on the reference points and positional relationship data of the dewar; and re-determine the positional relationships between the reference point of the subject and the sensors, based on images that are acquired by the single imaging device at different times. ## Claims ### Claim 1 A biological information measurement system comprising: a dewar covering a head of a subject and containing a plurality of sensors that are arranged for detecting biological signals; a single imaging device configured to acquire an image in which three or more reference points and the dewar are captured, the reference points being set in relation to the subject; a memory; and a hardware processor coupled to the memory, the hardware processor being configured to: measure brain neural activity of the subject based on the biological signals detected by the plurality of sensors; determine positional relationships between the reference points of the subject and the plurality of sensors based on the reference points and positional relationship data of the dewar; and re-determine the positional relationships between the reference points of the subject and the plurality of sensors, based on images that are acquired by the single imaging device at different times. ### Claim 2 (depends on 1) The biological information measurement system according to claim 1, further comprising three or more magnetic generators arranged on the subject, wherein the positional relationship data of the dewar is data representing positions at which the plurality of sensors are arranged, and the hardware processor is configured to perform the determination on the positional relationships between the reference points of the subject and the plurality of sensors, based on detection values of magnetic fields generated by the magnetic generators, the detection values being detected by the plurality of sensors, and the data representing the positions at which the plurality of sensors are arranged. ### Claim 3 (depends on 1) The biological information measurement system according to claim 1, wherein the positional relationship data of the dewar is data representing a shape of the dewar and positions at which the plurality of sensors are arranged, and the hardware processor is configured to: make, based on the image, positional relationships between the reference points and the dewar; and determine positional relationships between the reference points of the subject and the plurality of sensors in a three-dimensional space by using the data representing the shape of the dewar and the positions at which the plurality of sensors are arranged. ### Claim 4 (depends on 1) The biological information measurement system according to claim 1, wherein the single imaging device is capable of acquiring a three-dimensional shape image, the positional relationship data of the dewar is data representing a shape of the dewar and positions at which the plurality of sensors are arranged, and the hardware processor is configured to: make positional relationships between the reference points and the dewar in three-dimensional head shape data of the subject, based on an image that is acquired by the single imaging device and that includes the three-dimensional head shape data of the subject and three-dimensional shape data of the dewar; and determine positional relationships in a three-dimensional space between the reference points of the subject and the plurality of sensors, based on the data representing the shape of the dewar and the positions at which the plurality of sensors are arranged. ### Claim 5 (depends on 1) The biological information measurement system according to claim 1, wherein the reference points are feature points of a head of the subject. ### Claim 6 (depends on 1) The biological information measurement system according to claim 1, wherein the reference points are each provided with a mark having a known dimension that allows the single imaging device to capture the mark on the image. ### Claim 7 (depends on 1) The biological information measurement system according to claim 1, wherein the reference points are provided on skin over any of a maxilla bone, a frontal bone, a nasal bone, a zygomatic bone, and a temporal bone. ### Claim 8 A non-transitory computer-readable recording medium on which an executable program is recorded, the program giving an instruction to a hardware processor of a biological information measurement system that includes a dewar covering a head of a subject and containing a plurality of sensors that are arranged for detecting biological signals and includes a single imaging device configured to acquire an image in which three or more reference points and the dewar are captured, the reference points being set in relation to the subject, the instruction causing the hardware processor to: measure brain neural activity of the subject based on the biological signals detected by the plurality of sensors; determine positional relationships between the reference points of the subject and the plurality of sensors based on the reference points and positional relationship data of the dewar; and re-determine the positional relationships between the reference points of the subject and the plurality of sensors, based on images that are acquired by the single imaging device at different times. ### Claim 9 (depends on 8) The non-transitory computer-readable recording medium according to claim 8, wherein the biological information measurement system further includes three or more magnetic generators arranged on the subject, wherein the positional relationship data of the dewar is data representing positions at which the plurality of sensors are arranged, and the instruction further causes the hardware processor to perform the determination on the positional relationships between the reference points of the subject and the plurality of sensors, based on detection values of magnetic fields generated by the magnetic generators, the detection values being detected by the plurality of sensors, and the data representing the positions at which the plurality of sensors are arranged. ### Claim 10 (depends on 8) The non-transitory computer-readable recording medium according to claim 8, wherein the positional relationship data of the dewar is data representing a shape of the dewar and positions at which the plurality of sensors are arranged, and the instruction further causes the hardware processor to: make, based on the image, positional relationships between the reference points and the dewar; and determine positional relationships between the reference points of the subject and the plurality of sensors in a three-dimensional space by using the data representing the shape of the dewar and the positions at which the plurality of sensors are arranged. ### Claim 11 (depends on 8) The non-transitory computer-readable recording medium according to claim 8, wherein the single imaging device is capable of acquiring a three-dimensional shape image, the positional relationship data of the dewar is data representing a shape of the dewar and positions at which the plurality of sensors are arranged, and the instruction further causes the hardware processor to: make positional relationships between the reference points and the dewar in three-dimensional head shape data of the subject, based on an image that is acquired by the single imaging device and that includes the three-dimensional head shape data of the subject and three-dimensional shape data of the dewar; and determine positional relationships in a three-dimensional space between the reference points of the subject and the plurality of sensors, based on the data representing the shape of the dewar and the positions at which the plurality of sensors are arranged. ### Claim 12 (depends on 8) The non-transitory computer-readable recording medium according to claim 8, wherein the reference points are feature points of a head of the subject. ### Claim 13 (depends on 8) The non-transitory computer-readable recording medium according to claim 8, wherein the reference points are each provided with a mark having a known dimension that allows the single imaging device to capture the mark on the image. ### Claim 14 (depends on 8) The non-transitory computer-readable recording medium according to claim 8, wherein the reference points are provided on skin over any of a maxilla bone, a frontal bone, a nasal bone, a zygomatic bone, and a temporal bone. ### Claim 15 (depends on 8) The non-transitory computer-readable recording medium according to claim 8, wherein the instruction further causes the hardware processor to: determine distances from the single imaging device to the reference points of the subject based on three-dimensional head shape data of the subject and three- dimensional shape data of the dewar; and determine the positional relationships between the reference points of the subject and the plurality of sensors based on the determined distances. ### Claim 16 (depends on 8) The non-transitory computer-readable recording medium according to claim 8, wherein the instruction further causes the hardware processor to: determine a relative position change of the subject based on the images that are acquired by the single imaging device at different times. ### Claim 17 (depends on 16) The non-transitory computer-readable recording medium according to claim 16, wherein the instruction further causes the hardware processor to: correct the position of the subject based on the determined relative position change. ### Claim 18 (depends on 1) The biological information measurement system according to claim 1, wherein the hardware processor is further configured to: determine distances from the single imaging device to the reference points of the subject based on three-dimensional head shape data of the subject and three- dimensional shape data of the dewar; and determine the positional relationships between the reference points of the subject and the plurality of sensors based on the determined distances. ### Claim 19 (depends on 1) The biological information measurement system according to claim 1, wherein the hardware processor is further configured to: determine a relative position change of the subject based on the images that are acquired by the single imaging device at different times. ### Claim 20 (depends on 19) The biological information measurement system according to claim 19, wherein the hardware processor is further configured to: correct the position of the subject based on the determined relative position change.