# US 11,439,304 B2 · Systems and methods including electrolyte sensor fusion

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- Number: US 11,439,304 B2
- Document ID: US11439304B2
- Status: Granted
- Kind: B2
- Application number: 16/038,737
- Filed: 2018-07-18
- Published: 2019-02-14
- Granted: 2022-09-13
- Earliest claimed: 2017-08-10
- Assignees: Cardiac Pacemakers, Inc.
- Applicants: Cardiac Pacemakers, Inc.
- Inventors: Jeffrey E. Stahmann; Yingbo Li; Michael John Kane
- Web page: https://patentgrep.com/patent/US11439304B2

## CPC

- A61B 5/0006: {ECG or EEG signals}
- A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes}
- A61B 5/1473: invasive, e.g. introduced into the body by a catheter
- A61B 5/29: for permanent or long-term implantation
- A61B 5/686: {Permanently implanted devices, e.g. pacemakers, other stimulators, biochips (A61B5/6861 takes precedence)}
- G01N 27/3273: {Devices therefor, e.g. test element readers, circuitry (details not specific to biochemical electrodes G01N33/4875)}
- A61B 5/0031: {Implanted circuitry}
- A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement}
- A61B 5/14539: {for measuring pH}
- A61B 5/7278: {Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals}
- G01N 27/413: Concentration cells using liquid electrolytes {measuring currents or voltages in voltaic cells}
- G01N 27/4167: {pH (electrodes therefor G01N27/302, G01N27/36)}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

Embodiments herein relate to systems and methods for combining data from different types of sensors. In an embodiment, a medical system is included. The medical system can include a first sensor configured to produce a first value for an analyte and a second sensor different than the first sensor, the second sensor configured to produce a second value for the analyte. The medical system can also include a controller configured to receive the first and second values. The controller can create a blended analyte value from the first value and second value. Other embodiments are included herein.

## Claims

### Claim 1

A medical system comprising
a first sensor configured to produce a first value for an analyte, wherein the analyte is an electrolyte;
a second sensor configured to produce a second value for the analyte, wherein the second sensor is a different type of sensor than the first sensor; and
a controller configured to receive the first and second values;
wherein the controller triggers a measurement change of the second sensor based on the first value for the analyte and;
wherein the first sensor and the second sensor are implantable;
wherein the first sensor has a faster response time than the second sensor;
wherein the first sensor is an implantable electrical ECG sensor; and
wherein the second sensor is an implantable diffusion based optical chemical sensor.

### Claim 2 (depends on 1)

The medical system of claim 1, wherein the measurement change is selected from the group consisting of sampling frequency, measurement schedule, measurement intensity, and turning the sensor on or off.

### Claim 3 (depends on 1)

The medical system of claim 1, wherein data from the first sensor is used for trend analysis of data from the second sensor.

### Claim 4 (depends on 1)

The medical system of claim 1, wherein data from the second sensor is used for trend analysis of data from the first sensor.

### Claim 5 (depends on 1)

The medical system of claim 1, wherein the controller creates a blended analyte value from the first value and second value.

### Claim 6 (depends on 5)

The medical system of claim 5, wherein the blended analyte value is created using a method that reduces at least one of sensor offset errors, sensor gain errors and sensor latency.

### Claim 7 (depends on 1)

The medical system of claim 1, wherein the first sensor is faster reacting than the second sensor.

### Claim 8 (depends on 1)

The medical system of claim 1, wherein the faster response time of the first sensor comprises a response time of from 1 second to 5 minutes, and wherein the response time comprises a time until a steady-state level of sensor response is achieved after a change in the intrinsic value being measure.

### Claim 9 (depends on 1)

The medical system of claim 1, wherein the chemical sensor is configured to detect an analyte of interest from the in vivo environment that has diffused into the optical chemical sensor and caused a detectable change in the optical properties of the chemical sensor.

### Claim 10

A medical system comprising
a first sensor configured to produce a first value for an analyte, wherein the analyte is an electrolyte;
a second sensor configured to produce a second value for the analyte, wherein the second sensor is a different type of sensor than the first sensor; and
a controller configured to receive the first and second values;
wherein the controller triggers a measurement change of the second sensor based on the first value for the analyte;
wherein the measurement change is selected from the group consisting of sampling frequency, measurement schedule, and measurement intensity; and
wherein the first sensor is an implantable electrical ECG sensor and the second sensor is an implantable diffusion based optical chemical sensor; and
wherein the first sensor has a faster response time than the second sensor.

### Claim 11 (depends on 10)

The medical system of claim 10, wherein data from the first sensor is used for trend analysis of data from the second sensor.

### Claim 12 (depends on 10)

The medical system of claim 10, wherein data from the second sensor is used for trend analysis of data from the first sensor.

### Claim 13 (depends on 10)

The medical system of claim 10, wherein the controller creates a blended analyte value from the first value and second value.

### Claim 14

A medical system comprising
a first sensor configured to produce a first value for an analyte, wherein the analyte is an electrolyte;
a second sensor configured to produce a second value for the analyte, wherein the second sensor is a different type of sensor than the first sensor; and
a controller configured to receive the first and second values;
wherein the controller triggers a measurement change of the second sensor based on the first value for the analyte; and
wherein the first sensor is an implantable electrical ECG sensor and the second sensor is an implantable diffusion based optical chemical sensor; and
wherein the first sensor has a faster response time than the second sensor.

### Claim 15 (depends on 14)

The medical system of claim 14, wherein the controller creates a blended analyte value by using the first value to normalize the second value or by using the second value to normalize the first value.

### Claim 16 (depends on 15)

The medical system of claim 15, wherein the blended analyte value is created using a method that reduces at least one of sensor offset errors, sensor gain errors and sensor latency as compared with values from the first sensor and second sensor standing alone.
