# US 11,439,301 B2 · Ophthalmologic information processing apparatus, ophthalmologic apparatus and ophthalmologic information processing method > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,439,301 B2 - Document ID: US11439301B2 - Status: Granted - Kind: B2 - Application number: 16/408,483 - Filed: 2019-05-10 - Published: 2020-07-16 - Granted: 2022-09-13 - Earliest claimed: 2019-01-16 - Assignees: Topcon Corporation - Applicants: Topcon Corporation - Inventors: Toshihiro Mino; Jonathan Liu - Web page: https://patentgrep.com/patent/US11439301B2 ## CPC - A61B 3/102: {for optical coherence tomography [OCT]} - A61B 3/0025: {characterised by electronic signal processing, e.g. eye models} - A61B 3/103: for determining refraction, e.g. refractometers or skiascopes - G06T 7/0012: {Biomedical image inspection} - G06T 7/11: Region-based segmentation - G06T 7/136: involving thresholding - A61B 3/14: Arrangements specially adapted for eye photography - G06T 2207/10101: Optical tomography; Optical coherence tomography [OCT] - G06T 2207/30041: Eye; Retina; Ophthalmic - G16H 30/40: for processing medical images, e.g. editing - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract An ophthalmologic information processing apparatus includes an acquisition unit, a tissue specifying unit, and a specifying unit. The acquisition unit is configured to acquire a tomographic image of a subject's eye. The tissue specifying unit is configured to acquire first shape data representing shape of a tissue of the subject's eye by performing segmentation processing on each of a plurality of tomographic images acquired by the acquisition unit. The specifying unit is configured to obtain second shape data representing shape of the tissue based on the plurality of first shape data acquired by the tissue specifying unit. ## Claims ### Claim 1 An ophthalmologic information processing apparatus comprising: an acquisition unit configured to acquire a tomographic image of a subject's eye: a tissue specifying unit configured to acquire first shape data representing shape of a tissue of the subject's eye by performing segmentation processing on each of a plurality of tomographic images acquired by the acquisition unit; and a specifying unit configured to obtain second shape data representing shape of the tissue based on a plurality of first shape data acquired by the tissue specifying unit, wherein the first shape data includes a shape profile representing a change in shape in a predetermined one-dimensional direction, a predetermined two-dimensional direction, or a predetermined three-dimensional direction. ### Claim 2 (depends on 1) The ophthalmologic information processing apparatus of claim 1, wherein the specifying unit obtains the second shape data by performing statistical processing on the plurality of first shape data on which registration has been performed by a registration processor to obtain a statistical value for each scan position of an OCT scan in the plurality of first shape data. ### Claim 3 (depends on 2) The ophthalmologic information processing apparatus of claim 2, wherein the statistical processing includes a median calculation processing. ### Claim 4 (depends on 2) The ophthalmologic information processing apparatus of claim 2, wherein the statistical processing includes a mode calculation processing. ### Claim 5 (depends on 2) The ophthalmologic information processing apparatus of claim 2, wherein the statistical processing includes a maximum likelihood value calculation processing. ### Claim 6 (depends on 1) The ophthalmologic information processing apparatus of claim 1, wherein the specifying unit obtains the second shape data based on a maximum likelihood value obtained by performing statistical processing on the plurality of first shape data. ### Claim 7 (depends on 6) The ophthalmologic information processing apparatus of claim 6, wherein the statistical processing includes averaging processing. ### Claim 8 (depends on 1) The ophthalmologic information processing apparatus of claim 1, further comprising a registration processor that performs registration of the plurality of first shape data acquired by the tissue specifying unit, wherein the specifying unit obtains the second shape data based on the plurality of first shape data on which registration has been performed by the registration processor. ### Claim 9 (depends on 8) The ophthalmologic information processing apparatus of claim 8, wherein the registration processor obtains a shift amount based on a correlation value of the plurality of tomographic images, and performs registration of the plurality of first shape data based on the obtained shift amount. ### Claim 10 (depends on 8) The ophthalmologic information processing apparatus of claim 8, wherein the registration processor performs registration of the plurality of first shape data based on constant terms of polynomials obtained by performing polynomial approximation on each of the plurality of first shape data. ### Claim 11 (depends on 8) The ophthalmologic information processing apparatus of claim 8, wherein the registration processor extracts each characteristic parts of the plurality of first shape data, and performs registration of the plurality of first shape data with reference to the extracted characteristic parts. ### Claim 12 (depends on 1) The ophthalmologic information processing apparatus of claim 1, wherein the tissue includes a predetermined layer region in a fundus. ### Claim 13 (depends on 12) The ophthalmologic information processing apparatus of claim 12, further comprising a calculator that calculates a refractive power of a peripheral region of a region including a fovea of the subject's eye based on a refractive power obtained by objectively measuring the subject's eye and parameter representing optical characteristics of the subject's eye corresponding to the shape of the tissue on the basis of the second shape data acquired by the specifying unit. ### Claim 14 (depends on 13) The ophthalmologic information processing apparatus of claim 13, wherein the shape of the tissue includes a tilt angle of the tissue with respect to a predetermined reference direction. ### Claim 15 (depends on 1) An ophthalmologic apparatus comprising the ophthalmologic information processing apparatus of claim 1, wherein the acquisition unit includes an OCT unit configured to acquire the tomographic image of the subject's eye by performing optical coherence tomography. ### Claim 16 (depends on 1) The ophthalmologic information processing apparatus of claim 1, wherein the plurality of shape data have different alignment conditions and scan patterns. ### Claim 17 (depends on 1) The ophthalmologic information processing apparatus of claim 1, wherein the tomographic image of the subject's eye is acquired by performing an OCT scan. ### Claim 18 An ophthalmologic information processing apparatus comprising: an acquisition unit configured to acquire a tomographic image of a subject's eye; a tissue specifying unit configured to acquire first shape data representing shape of a tissue of the subject's eye by performing segmentation processing on each of a plurality of tomographic images acquired by the acquisition unit; a specifying unit configured to obtain second shape data representing shape of the tissue based on a plurality of first shape data acquired by the tissue specifying unit; a registration processor that performs registration of the plurality of tomographic images, wherein the tissue specifying unit performs segmentation processing on each of the plurality of tomographic images on which registration has been performed by the registration processor, and the first shape data includes a shape profile representing a change in shape in a predetermined one-dimensional direction, a predetermined two-dimensional direction, or a predetermined three-dimensional direction. ### Claim 19 (depends on 18) The ophthalmologic information processing apparatus of claim 18, wherein the registration processor obtains a shift amount based on a correlation value of the plurality of tomographic images, and performs registration of the plurality of tomographic images based on the obtained shift amount. ### Claim 20 (depends on 18) The ophthalmologic information processing apparatus of claim 18, wherein the tomographic: age of the subject's eye is acquired by performing an OCT scan. ### Claim 21 (depends on 18) The ophthalmologic information processing apparatus of claim 18, wherein the specifying unit obtains the second shape data by performing statistical processing on the plurality of first shape data to obtain a statistical value for each scan position of the OCT scan in the plurality of first shape data. ### Claim 22 An ophthalmologic information processing method comprising: a tomographic image acquisition step that acquires a tomographic image of a subject's eye; a tissue specifying step that acquires first shape data representing shape of a tissue of the subject's eye by performing segmentation processing on each of a plurality of tomographic images acquired in the tomographic image acquisition step; a specifying step that obtains second shape data representing shape of the tissue based on the plurality of first shape data acquired in the tissue specifying step, wherein the first shape data including a shape profile representing a change in shape in a predetermined one-dimensional direction, a predetermined two-dimensional direction, or a predetermined three-dimensional direction. ### Claim 23 (depends on 22) The ophthalmologic information processing method of claim 22, wherein the specifying step obtains the second shape data by performing statistical processing on the plurality of first shape data. ### Claim 24 (depends on 22) The ophthalmologic information processing method of claim 22, further comprising a registration processing step that performs registration of the plurality of first shape data acquired in the tissue specifying step, wherein the specifying step obtains the second shape data by performing statistical processing on the plurality of first shape data based on the plurality of first shape data on which registration has been performed in the registration processing step to obtain a statistical value for each scan position of the OCT scan in the plurality of first shape data. ### Claim 25 (depends on 22) The ophthalmologic information processing method of claim 22, wherein the tissue includes a predetermined layer region in a fundus. ### Claim 26 (depends on 25) The ophthalmologic information processing method of claim 25, further comprising a calculation step that calculates a refractive power of a peripheral region of a region including a fovea of the subject's eye based on a refractive power obtained by objectively measuring the subject's eye and parameter representing optical characteristics of the subject's eye corresponding to the shape of the tissue on the basis of the second shape data acquired in the specifying step. ### Claim 27 (depends on 22) The ophthalmologic information processing method of claim 22, further comprising acquiring the tomographic image of the subject's eye by performing an OCT scan. ### Claim 28 An ophthalmologic information processing method comprising: a tomographic image acquisition step that acquires a tomographic image of a subject's eye; a tissue specifying step that acquires first shape data representing shape of a tissue of the subject's eye by performing segmentation processing on each of a plurality of tomographic images acquired in the tomographic image acquisition step; a specifying step that obtains second shape data representing shape of the tissue based on the plurality of first shape data acquired in the tissue specifying step a registration processing step that performs registration of the plurality of tomographic images, wherein the tissue specifying step performs segmentation processing on the plurality of tomographic images on which registration has been performed in the registration processing step, and the first shape data includes a shape profile representing a change in shape in a predetermined one-dimensional direction, a predetermined two-dimensional direction, or a predetermined three-dimensional direction.