# US 11,439,144 B2 · Apparatus and methods for delivering cold perfusion fluids in organ donors

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- Number: US 11,439,144 B2
- Document ID: US11439144B2
- Status: Granted
- Kind: B2
- Application number: 16/201,368
- Filed: 2018-11-27
- Published: 2020-05-28
- Granted: 2022-09-13
- Earliest claimed: 2018-11-27
- Assignees: Gift of Hope Organ & Tissue Donor Network
- Applicants: Martin Jendrisak
- Inventors: Martin Jendrisak
- Web page: https://patentgrep.com/patent/US11439144B2

## CPC

- A01N 1/143: for organ perfusion
- A61B 17/3421: {Cannulas}
- A61F 7/12: Devices for heating or cooling internal body cavities
- A61M 25/00: Catheters; Hollow probes (dilators A61M29/00; {peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00} ; for measuring or testing A61B; {materials for catheters A61L29/00})
- A61M 25/0097: {characterised by the hub (tube connectors or tube couplings A61M39/10)}
- A61B 2017/00969: {used for transplantation}
- A61F 2007/0063: {for cooling}
- A61F 2007/0288: {during operations}
- A61F 2007/126: {for invasive application, e.g. for introducing into blood vessels}
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

The present disclosure relates to devices and methods for increasing the probability of a successful organ donation by decreasing organs' warm ischemia time. Furthermore, the present disclosure relates to increasing the pool of eligible donors, including donors who had prior chest surgeries or prior abdominal surgeries. The present disclosure provides a catheter extending through a cannula, wherein the cannula delivers cold perfusion fluid and the catheter blocks the aorta, forcing the cold perfusion fluid to pass to organs in the donor's abdomen. The present disclosure further provides for advancing the catheter from a retracted position to an extended position, and creating a watertight seal at the cannula to prevent backflow of cold perfusion fluid.

## Claims

### Claim 1

An apparatus for achieving endovascular control and delivering cold perfusion fluid in organ donors, comprising:
a cannula having a proximal and a distal end; the proximal end being attached to a y-connector having a first branch and a second branch, the first branch being connected to a perfusion line;
a rubber stop affixed to the second branch;
a catheter comprising an inflatable balloon, a hub, a balloon port, and a distal port;
wherein the catheter extends through the second branch and into the cannula;
wherein the hub of the catheter is configured to form a watertight seal by press-fit engagement with the rubber stop when the catheter is in an extended position.

### Claim 2 (depends on 1)

The apparatus of claim 1, wherein the perfusion line contains perfusion fluid which is cold.

### Claim 3 (depends on 1)

The apparatus of claim 1, further comprising a syringe attached, through a stopcock, to the balloon port.

### Claim 4 (depends on 3)

The apparatus of claim 3, wherein the catheter has a retracted position in which the balloon is deflated and positioned inside the distal end of the cannula, and wherein the catheter extends a predetermined length beyond the proximal end of the cannula.

### Claim 5 (depends on 4)

The apparatus of claim 4, wherein the catheter is configured to be advanced through the cannula by the predetermined length to the extended position, and the balloon is inflated in the extended position.

### Claim 6 (depends on 5)

The apparatus of claim 5, wherein the predetermined length is 20 cm.

### Claim 7 (depends on 6)

The apparatus of claim 6, wherein the cannula is tapered from the proximal end down to the distal end, and wherein the distal end is 24 French in diameter.

### Claim 8 (depends on 7)

The apparatus of claim 7, wherein the catheter is 7 French in diameter.