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US 11,434,196 B2Granted
Process for preparation of 2-Amino-5-hydroxy propiophenone
AssigneeLaurus Labs Limited
InventorsUma Maheswer Rao Vasireddi, Venkata Ramana Kintali, Jagadeeswara Rao Dadi, Raj Koti Katkuri, Sridhar Tummu
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Abstract
The present invention relates to a process for preparation of 2-Amino-5-hydroxy propiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).
Claims31
A process for preparation of 2-amino-5-hydroxy propiophenone of Formula I,
- comprising:
- a) reacting a compound of Formula III with a suitable nitrating reagent to obtain a compound of Formula IV,
- wherein “PG” represents a suitable hydroxyl protecting group;
- and
- b) converting the compound of Formula IV into the 2-amino-5-hydroxy propiophenone of Formula I.
2 more elements
A process for preparation of 2-amino-5-hydroxy propiophenone of Formula I,
- comprising:
- a) reacting a compound Formula II with a suitable hydroxyl protecting agent to obtain a compound of Formula III,
- wherein “PG” represents a suitable hydroxyl protecting group;
- b) reacting the compound of Formula III with a suitable nitrating reagent to obtain a compound of Formula IV,
- c) deprotecting the compound of Formula IV with a suitable deprotecting agent to obtain a compound of Formula V,
- and
- d) reducing the compound of Formula V with a suitable reducing agent to obtain 2-Amino-5-hydroxy propiophenone of Formula I or
- e) reducing the compound of Formula IV with a suitable reducing agent to obtain a compound of Formula VI,
- and
- f) deprotecting the compound of Formula VI with a suitable deprotecting agent to obtain the 2-amino-5-hydroxy propiophenone of Formula I.
7 more elements
Dependencies are inferred from the claim text.