# US 11,433,160 B2 · Formed sheet product and hemostatic material

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- Number: US 11,433,160 B2
- Document ID: US11433160B2
- Status: Granted
- Kind: B2
- Application number: 16/659,830
- Filed: 2019-10-22
- Published: 2020-02-13
- Granted: 2022-09-06
- Earliest claimed: 2012-05-14
- Assignees: Teijin Limited; KM Biologics Co., Ltd.
- Applicants: Teijin Limited; Km Biologics Co., Ltd.
- Inventors: Yukako Kageyama; Kentaro Fujinaga; Ayuko Yamaguchi; Yusuke Akiyama; Akitoshi Oono; Susumu Honda; Makoto Satake; Hiroaki Kaneko; Takayuki Imamura; Ryoichi Kawamura; Masaki Hirashima
- Web page: https://patentgrep.com/patent/US11433160B2

## CPC

- A61L 26/0066: {Medicaments; Biocides}
- A61K 38/363: {Fibrinogen}
- A61K 38/4833: {Thrombin (3.4.21.5)}
- A61L 24/0015: {Medicaments; Biocides}
- A61L 24/0036: {Porous materials, e.g. foams or sponges}
- A61L 24/0042: {Materials resorbable by the body}
- A61L 24/043: {Mixtures of macromolecular materials}
- A61L 26/0052: {Mixtures of macromolecular compounds}
- A61L 26/0085: {Porous materials, e.g. foams or sponges}
- A61L 26/009: {Materials resorbable by the body}
- A61P 7/04: Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A61P 41/00: Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A61L 2300/25: Peptides having up to 20 amino acids in a defined sequence
- A61L 2300/252: Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L 2300/418: Agents promoting blood coagulation, blood-clotting agents, embolising agents
- A61L 2400/04: Materials for stopping bleeding
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.

## Claims

### Claim 1

A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin, and an aliphatic polyester, wherein at least one part of said at least one protein is incorporated into and is not covalently bonded to said aliphatic polyester, and
wherein the formed sheet product is manufactured from a suspension composed of a solution of the aliphatic polyester and particles of the protein.

### Claim 2 (depends on 1)

The formed sheet product according to claim 1, wherein the aliphatic polyester is selected from the group consisting of polyglycolic acid, polylactic acid, polycaprolactone, a copolymer thereof, and a mixture thereof.

### Claim 3 (depends on 1)

The formed sheet product according to claim 1, wherein the formed sheet product is a formed film product or a formed fiber product.

### Claim 4 (depends on 1)

A hemostatic material comprising the formed sheet product according to claim 1.

### Claim 5 (depends on 1)

A tissue adhesive material or tissue closure material comprising the formed sheet product according to claim 1.