# US 11,433,149 B2 · Microsphere and preparation method thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,433,149 B2 - Document ID: US11433149B2 - Status: Granted - Kind: B2 - Application number: 16/280,366 - Filed: 2019-02-20 - Published: 2020-01-23 - Granted: 2022-09-06 - Earliest claimed: 2018-03-05 - Assignees: Platinum Optics Technology Inc. - Applicants: Platinum Optics Technology Inc. - Inventors: Yu-Yu Tsai; Fu-Yu Chang; Chien-Liang Liu - Web page: https://patentgrep.com/patent/US11433149B2 ## CPC - A61K 51/1255: {Granulates, agglomerates, microspheres} - A61B 6/481: {involving the use of contrast agents} - A61N 5/1001: {using radiation sources introduced into or applied onto the body; brachytherapy} - A61N 5/1007: {Arrangements or means for the introduction of sources into the body} - G21G 1/06: by neutron irradiation - G21G 4/08: specially adapted for medical application (radiation therapy using radioactive sources A61N5/10) - G21K 5/02: having no beam-forming means - A61N 2005/1019: {Sources therefor} - A61N 2005/1021: {Radioactive fluid} - A61N 2005/109: {Neutrons} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - G21G: CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES (applications of radiation in general G21H5/00; handling particles, e.g. neutrons, or electromagnetic radiation not otherwise provided for G21K) - G21K: HANDLING OF PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES ## Abstract Provided is a microsphere including a glass sphere core. The glass sphere core includes a first nuclide, a second nuclide and a diffusion region extending inwardly from an outer surface of the glass sphere core, with the second nuclide distributed in the diffusion region. The first nuclide and the second nuclide become radioactive after being activated by neutrons to produce radiations including β-rays or γ-rays, or simultaneously β-rays and γ-rays. A preparation method of a microsphere is also provided. ## Claims ### Claim 1 A microsphere, comprising: a glass sphere core comprising a first nuclide, a second nuclide, and a diffusion region extending inwardly from an outer surface of the glass sphere core, wherein the size of the diffusion region is less than the size of the glass sphere core, wherein the first nuclide is distributed throughout the glass sphere core, the second nuclide is only distributed in the diffusion region and not present out of the diffusion region, and the first nuclide and the second nuclide both are capable of being radioactive to produce radiations comprising γ-rays or β-rays, or simultaneously γ-rays and β-rays. ### Claim 2 (depends on 1) The microsphere of claim 1, further comprising a shell layer coating the glass sphere core. ### Claim 3 (depends on 2) The microsphere of claim 2, wherein a material of the shell layer comprises one of an organic material, an inorganic material, or a combination thereof. ### Claim 4 (depends on 1) The microsphere of claim 1, wherein the first nuclide comprises one of yttrium, aluminum, silicon, or a combination thereof. ### Claim 5 (depends on 1) The microsphere of claim 1, wherein the second nuclide is at least one selected from the group consisting of: phosphorus, calcium, sodium, rhenium, scandium, lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, erbium, thulium, ytterbium, lutetium, actinium, antimony, arsenic, barium, bismuth, californium, carbon, cesium, chromium, cobalt, fluorine, gallium, gold, holmium, hydrogen, indium, iodine, iridium, iron, krypton, molybdenum, nitrogen, oxygen, palladium, radon, radium, rhodium, selenium, strontium, technetium, thallium, xenon and yttrium. ### Claim 6 (depends on 3) The microsphere of claim 3, wherein the material is an organic material, and the organic material comprises an acid group, a hydroxyl group, an amine group or a biodegradable material. ### Claim 7 (depends on 6) The microsphere of claim 6, wherein the organic material is at least one selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, carboxymethyl cellulose, methyl cellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyethylene glycol, gum arabic and a copolymer of polylactic acid and polylactic acid-glycolic acid. ### Claim 8 (depends on 3) The microsphere of claim 3, wherein the material is an inorganic material, and the inorganic material comprises a phosphate compound, a sulfate compound, a chlorine salt compound, a nitrate compound or a borate compound. ### Claim 9 (depends on 3) The microsphere of claim 3, wherein the shell layer is further grafted with a radioactive therapeutic agent or a radioactive contrast agent. ### Claim 10 A method for preparing a microsphere, comprising: heating glass powder comprising a first nuclide to spheroidize and form a glass sphere core; and reacting the glass sphere core with a cooling source, wherein the cooling source is a saturated liquid containing a second nuclide liquid phase component with a second nuclide diffused into the glass sphere core by being thermally activated to form a diffusion region extending inwardly from an outer surface of the glass sphere core, wherein the first nuclide and the second nuclide are capable of being radioactive to produce radiations comprising β-rays or γ-rays, or simultaneously β-rays and γ-rays. ### Claim 11 (depends on 10) The method of claim 10, further comprising forming a shell layer coating the glass sphere core by a spray process. ### Claim 12 (depends on 11) The method of claim 11, wherein the shell layer is grafted with a radioactive therapeutic agent or a radioactive contrast agent.