Nanocarriers and intracellular delivery of same
AssigneeGeorgia Tech Research Corporation
InventorsJulie Champion, Sung In Lim, Anshul Dhankher
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Abstract
An embodiment of the present disclosure can include a nanocarrier for delivering a cargo to a cell comprising: a bundle domain and a binding domain, the binding domain configured to bind to the cargo. An embodiment of the present disclosure can include a method for delivering a cargo to a cell comprising: introducing an amino-acid based nanocarrier to the cell, the nanocarrier can comprise an alpha-helical protein bundle domain and a binding domain, the cargo can bound to the binding domain and the cargo can be therapeutic cargo.
Claims13
An endocytic method of delivering a nanocarrier into a cell and to a target comprising:
- transporting a nanocarrier into a cell via endocytosis,
- wherein the nanocarrier comprises a core comprising a hexamer bundle domain comprising an alpha-helical protein comprising three or more coils and being approximately 11 nm in length;
- and the core is fused to a cargo comprising a protein;
- and
- wherein a target is located in the cytosol of the cell.
Dependencies are inferred from the claim text.