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US 11,433,130 B2Granted
Recombinant turkey herpesvirus vaccines and uses thereof
AssigneeThe Texas A&M University System
InventorsSanjay M. Reddy, Blanca M. Lupiani
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Abstract
The present disclosure provides a recombinant viral vector comprising at least one transgene inserted into a Marek's disease viral genome for treatment of diseases in poultry. Also provided are immunogenic compositions comprising such recombinant viral vectors and methods for preventing or inhibiting Marek's disease in combination with at least a second disease in poultry.
Claims24
A recombinant viral vector comprising at least one transgene inserted into a Marek's disease viral genome in a region selected from the group consisting of:
- (a) an intergenic region flanked by HVT10 (UL3) and HVT11 (UL4) in the unique long region of the genome;
- and
- (b) an intergenic region flanked by HVT86 (US10) and HVT87 (Sorf3) in the unique short region of the genome,
- wherein the at least one transgene expresses at least one gene selected from infectious bursal disease virus gene, a Newcastle disease virus gene, an avian influenza virus gene, an infectious laryngotracheitis virus gene, and an infectious bronchitis virus gene.
1 more element
Dependencies are inferred from the claim text.