Composition for cell protection containing cyclo histidine-proline as active ingredient
AssigneeNovmetapharma Co., Ltd.
InventorsHoe-Yune Jung, Heon-Jong Lee, Jong-Su Jeon, Yon-Su Kim, Seung-Hee Yang, Yong-Chul Kim, Jong-Joo Moon, Hwan-Soo Yoo, Kyeong-Mi Choi
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Abstract
A new use of a cyclo histidine-proline (Cyclo His-Pro, CHP) is disclosed. A composition including cyclo histidine-proline (CHP) as an active ingredient has an excellent protective effect to protect kidney and liver cells from damage and/or toxicity induced by various causes. The composition is useful and effective in protecting kidney and/or liver cells/tissues and in treating a subject with kidney and/or liver diseases and/or damages.
Claims18
A method of treating a subject (a) suffering from a liver disease, (b) having liver cell damage, and/or (c) suffering from liver toxicity,
- comprising administering an effective amount of a composition comprising cyclo histidine-proline (CHP) or its pharmaceutically acceptable salt as an active ingredient to the subject,
- wherein the administering the composition suppresses apoptosis of liver cells, and
- wherein the liver disease is hepatic failure, acute hepatitis, chronic hepatitis, liver cirrhosis, hepatic coma, or alcoholic liver disease.
A method of treating a subject (a) suffering from a liver disease, (b) having liver cell damage, and/or (c) suffering from liver toxicity,
- comprising administering an effective amount of a composition comprising cyclo histidine-proline (CHP) or its pharmaceutically acceptable salt as an active ingredient to the subject,
- wherein the administering the composition suppresses apoptosis of liver cells, and
- wherein the apoptosis of liver cells is caused by administration of a drug.
A method of inhibiting liver cell apoptosis in a subject in need thereof, comprising administering an effective amount of a composition comprising cyclo histidine-proline (CHP) or its pharmaceutically acceptable salt as an active ingredient, to the subject,
- wherein the liver cell apoptosis is caused by administration of a drug;
- wherein the subject suffers from liver damage, liver toxicity, and/or liver disease, and
- wherein the liver disease is hepatic failure, acute hepatitis, chronic hepatitis, liver cirrhosis, hepatic coma, or alcoholic liver disease.
Dependencies are inferred from the claim text.