# US 11,433,113 B2 · CEACAM based antibacterial agents

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- Number: US 11,433,113 B2
- Document ID: US11433113B2
- Status: Granted
- Kind: B2
- Application number: 16/987,070
- Filed: 2020-08-06
- Published: 2021-04-15
- Granted: 2022-09-06
- Earliest claimed: 2006-02-27
- Applicants: Gal Markel
- Inventors: Gal Markel
- Web page: https://patentgrep.com/patent/US11433113B2

## CPC

- A61K 38/08: Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)}
- A23B 2/70: by treatment with chemicals
- A23B 2/762: Organic compounds containing nitrogen
- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A23L 33/195: Proteins from microorganisms
- C07K 7/06: having 5 to 11 amino acids
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23B: PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

Prophylactic and/or therapeutic antipathogen agents are provided that disrupt or prevent the formation of at least one homotypic and/or heterotypic protein-protein interaction that has at least one CEA-family protein and that is involved in the establishment and colonization of a pathogen in a suitable host.

## Claims

### Claim 1

A multimer therapeutic agent consisting of two or more different isolated peptides selected from the group consisting of SEQ ID No. 21-SEQ ID No. 24.

### Claim 2

A multimer therapeutic agent consisting of the isolated peptides NRQIV (SEQ ID No. 21), NRQII (SEQ ID No. 22), and QNDTG (SEQ ID No. 23).

### Claim 3

A multimer therapeutic agent consisting of the isolated peptides NRQIV (SEQ ID No. 21), NRQII (SEQ ID No. 22), and GYSWYK (SEQ ID. No. 24).