# US 11,433,110 B2 · Composition for treating fine dust-caused skin cell damage or for inhibiting antimicrobial peptide, comprising Hibiscus syriacus extract

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- Number: US 11,433,110 B2
- Document ID: US11433110B2
- Status: Granted
- Kind: B2
- Application number: 16/651,880
- Filed: 2018-08-20
- Published: 2020-07-23
- Granted: 2022-09-06
- Earliest claimed: 2017-09-29
- Assignees: Amorepacific Corporation
- Applicants: Amorepacific Corporation
- Inventors: Hyoung-June Kim; Tae Ryong Lee
- Web page: https://patentgrep.com/patent/US11433110B2

## CPC

- A61K 36/5775: {Hibiscus}
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61Q 19/00: Preparations for care of the skin
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Disclosed is a composition including a Hibiscus syriacus extract as an effective ingredient for treating fine dust-caused skin damage, wherein the expression of at least one selected from the group consisting of IL-36G (NM_019618), PTGS2 (NM_000963), XDH (NM_000379) and S100A7 (NM_002963), which are all genes having the expression levels affected by fine dust in skin cells, is regulated to a normal level and for inhibiting an antibacterial peptide, wherein the expression of the antibacterial peptide S100A7 (NM_002963) is regulated to a normal level. By using the composition for treating fine dust-caused skin damage and the composition for inhibiting an antibacterial peptide, gene expression changed by fine dust can return to a normal level to treat skin cell damage and the increased expression of the antibacterial peptide due to various causes can return to normal level.

## Claims

### Claim 1

A method for treating a human with skin cells damaged by particulate matter, comprising administering a composition comprising a Hibiscus syriacus extract as an active ingredient to the human,
wherein the damaged skin cells express one or more genes selected from the group consisting of IL-36G (NM_019618), PTGS2 (NM_000963), XDH (NM_000379) and S100A7 (NM_002963) in an increased amount compared to prior to exposure to the particulate matter,
wherein the particulate matter has a diameter of 2.5 μm or less; and
wherein the administering of the composition decreases expression of one or more genes selected from the group consisting of IL-36G (NM_019618), PTGS2 (NM_000963), XDH (NM_000379) and S100A7 (NM_002963) in the human compared to prior to the administration.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the Hibiscus syriacus extract is comprised in an amount of 0.000001-30 wt % based on the total weight of the composition.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the Hibiscus syriacus extract is obtained by extracting Hibiscus syriacus with a solvent selected from the group consisting of water, a C1-C6 anhydrous or water-containing lower alcohol, acetone, butylene glycol, ethyl acetate, diethyl acetate, diethyl ether, benzene, chloroform, hexane, and any combination thereof.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the Hibiscus syriacus extract is an extract of bark of Hibiscus syriacus.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the composition acts on keratinocytes.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the Hibiscus syriacus extract is administered at a dosage of 10-500 mg/kg/day.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the composition is a cosmetic composition.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the composition is a health functional food composition.