# US 11,433,105 B2 · Compositions and methods for enhancing hyperthermia therapy

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- Number: US 11,433,105 B2
- Document ID: US11433105B2
- Status: Granted
- Kind: B2
- Application number: 17/163,419
- Filed: 2021-01-30
- Published: 2021-05-27
- Granted: 2022-09-06
- Earliest claimed: 2017-06-13
- Applicants: Houn Simon Hsia
- Inventors: Houn Simon Hsia
- Web page: https://patentgrep.com/patent/US11433105B2

## CPC

- A61K 35/60: Fish, e.g. seahorses; Fish eggs
- A61K 33/04: Sulfur, selenium or tellurium; Compounds thereof
- A61K 36/064: Saccharomycetales, e.g. baker's yeast
- A61K 41/0052: {Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy}
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method for decreasing proliferation of cancer cells comprises the steps of administering a sensitizer. Sensitizers can include selenium, fish oil, and a combination of selenium and fish oil to a cancer cell. The method contemplates that the selenium and fish oil are administered in an amount effective to respectively increase the sensitivity of the cancer cells, and the administration of the combination of selenium and fish oil are administered in an amount effective to synergistically increase the sensitivity of the cancer cells more than the selenium or the fish oil alone. The method additionally exposes cancer cells to temperatures in excess of 37° C.

## Claims

### Claim 1

A method for decreasing proliferation of a cancer cell, comprising:
administering a sensitizer comprising selenium and fish oil to the cancer cell, wherein the sensitizer is administered in an amount sufficient to provide 12.5 μM fish oil and 0.5 μg/mL selenium to the cancer cell; and
exposing of the cancer cell to a hyperthermia therapy comprising a temperature in excess of 37° C., wherein fish oil, selenium, and the hyperthermia therapy in combination provide a synergistic effect that exceeds summation of monotherapy with fish oil, monotherapy with selenium, and monotherapy with the hyperthermia therapy, wherein the selenium is in the form of selenium yeast or a peptide derived from selenium yeast.