# US 11,433,020 B2 · Brightening skin care serums > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,433,020 B2 - Document ID: US11433020B2 - Status: Granted - Kind: B2 - Application number: 17/302,627 - Filed: 2021-05-07 - Published: 2021-08-26 - Granted: 2022-09-06 - Earliest claimed: 2014-06-12 - Assignees: Colorescience, Inc. - Applicants: Colorescience, Inc. - Inventors: Patricia McGill Boland; Deborah Eileen Gregg Bouche; John Anthony Garruto; Bethany Ann McCarver - Web page: https://patentgrep.com/patent/US11433020B2 ## CPC - A61K 8/9789: Magnoliopsida [dicotyledons] - A61K 8/19: containing inorganic ingredients - A61K 8/27: Zinc; Compounds thereof - A61K 8/29: Titanium; Compounds thereof - A61K 8/34: Alcohols - A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings - A61K 8/416: {Quaternary ammonium compounds (A61K8/35 takes precedence)} - A61K 8/4926: {having six membered rings} - A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin} - A61K 8/55: Phosphorus compounds - A61K 8/602: {Glycosides, e.g. rutin} - A61K 8/733: {Alginic acid; Salts thereof} - A61K 8/891: saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone - A61K 8/9711: Phaeophycota or Phaeophyta [brown algae], e.g. Fucus - A61K 8/9717: Rhodophycota or Rhodophyta [red algae], e.g. Porphyra - A61K 8/9722: Chlorophycota or Chlorophyta [green algae], e.g. Chlorella - A61K 8/9728: Fungi, e.g. yeasts - A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations - A61Q 19/00: Preparations for care of the skin - A61Q 19/007: {Preparations for dry skin} - A61Q 19/02: for chemically bleaching or whitening the skin - A61Q 19/08: Anti-ageing preparations - A61K 2800/30: Characterized by the absence of a particular group of ingredients - A61K 2800/43: Pigments; Dyes - A61K 2800/72: Hypo-allergenic - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract Formulations such as serums to treat skin discoloration via a multi-modal approach are provided in some embodiments. In several embodiments, the formulations are configured to allow select ingredients to work together to effectively brighten skin and treat hyperpigmentation. In several embodiments, the formulations comprise a first anti-melanin agent, such as a Bidens pilosa extract, a second anti-melanin agent, such as a Rheum rhaponticum extract, and an anti-inflammatory agent, such as a Vitamin E compound. In several embodiments, the formulation is provided as a topical formulation. ## Claims ### Claim 1 A formulation for treating skin discoloration comprising effective amounts of: a Bidens pilosa extract; an acetyl Rheum rhaponticum root extract; a Vitamin E compound; a preservative; and a Thermus thermophilus ferment extract, wherein the formulation is a topical formulation in the form of a serum. ### Claim 2 (depends on 1) The formulation of claim 1, wherein said formulation further comprises a glycerin. ### Claim 3 (depends on 1) The formulation of claim 1, wherein the vitamin E compound is a disodium lauriminodipropionate tocopheryl phosphate. ### Claim 4 (depends on 1) The formulation of claim 1, wherein said formulation is paraben-free and wherein said preservative comprises phenoxyethanol. ### Claim 5 (depends on 1) The formulation of claim 1, wherein the amount of the Bidens pilosa extract in the formulation is 0.05-5%, and wherein the amount of the acetyl Rheum rhaponticum root extract in the formulation is 0.005-5%. ### Claim 6 (depends on 1) The formulation of claim 1, wherein the amount of the Vitamin E compound in the formulation is 0.05-5%, and wherein the amount of the Thermus thermophilus ferment extract in the formulation is 0.5-10%. ### Claim 7 (depends on 1) The formulation of claim 1, wherein said formulation further comprises Elaeis Guineensis oil, Gossypium Herbaceum seed oil and Linum Usitatissimum seed oil. ### Claim 8 (depends on 1) The formulation of claim 1, further comprising a triglyceride. ### Claim 9 A formulation for treating skin discoloration, comprising effective amounts of: (i) a first anti-melanin agent, wherein said first anti-melanin agent comprises a Bidens pilosa extract; (ii) a second anti-melanin agent, wherein said second anti-melanin agent comprises a Rheum rhaponticum extract; (iii) an anti-inflammatory agent, wherein said anti-inflammatory agent comprises a Vitamin E compound; and (iv) a preservative; wherein the formulation is a topical formulation suitable for topical delivery. ### Claim 10 (depends on 9) The formulation of claim 9, further comprising a Thermus thermophilus ferment extract. ### Claim 11 (depends on 9) The formulation of claim 9, wherein said formulation further comprises a glycerin. ### Claim 12 (depends on 9) The formulation of claim 9, wherein the vitamin E compound is a disodium lauriminodipropionate tocopheryl phosphate. ### Claim 13 (depends on 9) The formulation of claim 9, wherein said formulation is paraben-free and wherein said preservative comprises phenoxyethanol. ### Claim 14 (depends on 9) The formulation of claim 9, wherein the amount of the first anti-melanin agent in the formulation is 0.05-5%, the amount of the second anti-melanin agent in the formulation is 0.005-5%, and the amount of the anti-inflammatory agent in the formulation is 0.05-5%. ### Claim 15 (depends on 9) The formulation of claim 9, wherein said formulation further comprises Elaeis Guineensis oil, Gossypium Herbaceum seed oil, and Linum Usitatissimum seed oil.