# US 11,433,013 B2 · Peptide for preventing skin damage caused by air pollutants and for anti-aging, and use thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,433,013 B2 - Document ID: US11433013B2 - Status: Granted - Kind: B2 - Application number: 17/059,909 - Filed: 2019-04-23 - Published: 2021-07-08 - Granted: 2022-09-06 - Earliest claimed: 2019-02-20 - Assignees: Caregen Co., Ltd. - Applicants: Caregen Co., Ltd. - Inventors: Yong Ji Chung; Eun Mi Kim; Eung Ji Lee - Web page: https://patentgrep.com/patent/US11433013B2 ## CPC - A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof - A61K 38/08: Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)} - A61Q 17/00: Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings - A61Q 19/08: Anti-ageing preparations - C07K 7/06: having 5 to 11 amino acids - C07K 14/4705: {stimulating, promoting or activating activity} - C07K 14/705: Receptors; Cell surface antigens; Cell surface determinants {(tumour specific antigens C07K14/4748)} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS - C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00) ## Abstract The present invention relates to: a novel peptide having activity of preventing skin damage caused by pollutants, and skin anti-aging and wrinkle alleviation activities; and a use of the peptide, which is related to the prevention or treatment of diseases caused by pollutants or to the improvement of skin anti-aging. Particularly, the novel peptide of the present invention inhibits the inflow, into skin cells, of pollutants such as dioxin, particulate matter, and cigarette smoke, and regulates the expression of a skin aging-related gene, and thus may be effectively used as an active ingredient of a pharmaceutical composition for preventing or treating cancer, skin diseases, and lung diseases, which are caused by pollutants, or skin aging-related diseases, or as an active ingredient of a cosmetic composition for preventing skin damage caused by pollutants or for a skin anti-aging effect. ## Claims ### Claim 1 A synthetic peptide having activity of inhibiting pollutants from inflow into skin, the synthetic peptide consisting of the amino acid sequence of SEQ ID No: 1, wherein the N-terminus or the C-terminus of the synthetic peptide is linked to a protective group, wherein the synthetic peptide adsorbs pollutants selected from the group consisting of dioxin, particulate matter, and cigarette smoke extract. ### Claim 2 (depends on 1) A pharmaceutical composition for preventing diseases caused by pollutants selected from the group consisting of dioxin, particulate matter, and cigarette smoke extract, the pharmaceutical composition comprising the synthetic peptide of claim 1 as an active ingredient. ### Claim 3 (depends on 2) The pharmaceutical composition of claim 2, wherein the diseases caused by pollutants are at least one selected from the group consisting of atopic dermatitis, contact dermatitis, seborrheic dermatitis, acne, dry skin, psoriasis, immunotoxicity, peripheral nervous system damage, central nervous system damage, endocrine abnormalities, anemia, bronchitis, emphysema, reduced lung function, asthma, and chronic bronchitis. ### Claim 4 (depends on 1) A pharmaceutical composition for improving skin anti-aging, the pharmaceutical composition comprising the synthetic peptide of claim 1 as an active ingredient. ### Claim 5 (depends on 4) The pharmaceutical composition of claim 4, wherein the improving skin anti-aging is reduction of wrinkles. ### Claim 6 (depends on 1) A cosmetic composition for preventing skin damage caused by pollutants or for improving skin anti-aging, the cosmetic composition comprising the synthetic peptide of claim 1 as an active ingredient. ### Claim 7 (depends on 6) The cosmetic composition of claim 6, wherein the cosmetic composition has at least one formulation selected from the group consisting of solution, suspension, emulsion, gel, lotion, essence, cream, powder, soap, shampoo, conditioner, pack mask, surfactant-containing cleanser, cleansing foam, cleansing water, oil, liquid foundation, cream foundation, and spray. ### Claim 8 A method of treating a disease caused by pollutants selected from the group consisting of dioxin, particulate matter, and cigarette smoke extract in a subject, the method comprising administering the synthetic peptide consisting of the amino acid sequence of SEQ ID NO: 1, wherein the N-terminus or the C-terminus of the peptide is linked to a protective group, to the subject, wherein the diseases caused by pollutants are at least one selected from the group consisting of atopic dermatitis, contact dermatitis, seborrheic dermatitis, acne, dry skin, psoriasis, immunotoxicity, peripheral nervous system damage, central nervous system damage, endocrine abnormalities, anemia, bronchitis, emphysema, reduced lung function, asthma, and chronic bronchitis. ### Claim 9 (depends on 1) A method of improving skin anti-aging, the method comprising administering a synthetic peptide of claim 1 to a subject. ### Claim 10 (depends on 2) The pharmaceutical composition of claim 2, wherein the pharmaceutical composition further comprises a pharmaceutically acceptable carrier, wherein the pharmaceutically acceptable carrier is lipids, liposomes, microspheres, or nano spherical particles.