# US 11,433,012 B2 · Peptides for increasing melanin in melanocytes

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- Number: US 11,433,012 B2
- Document ID: US11433012B2
- Status: Granted
- Kind: B2
- Application number: 16/763,207
- Filed: 2018-10-22
- Published: 2020-09-10
- Granted: 2022-09-06
- Earliest claimed: 2017-11-14
- Assignees: Conopco, Inc.
- Applicants: Conopco, Inc.
- Inventors: Ganesh Chandramowli; Ian Peter Stott; Sreenivasa Thimmaiah
- Web page: https://patentgrep.com/patent/US11433012B2

## CPC

- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61Q 19/04: for chemically tanning the skin (topical sun or radiation screening or tanning preparations A61Q17/04)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Disclosed is use of a compound of the formula (I) to increase the amount of melanin in melanocytes, where: R1 is formula (AA) in which, X is H, CH3, (CH2)n—CH3 or a substituted alkyl group, Y is H, CH3, (CH2)n—CH3 or a substituted alkyl group and Z is H or OH; and R2 is H, OH, NH2 or —O—(OH2)nβ where, n=1 to 3 and β is phenyl, naphthyl or alkyl group further optionally substituted with halogen, aryl or NH2 group, where compound of formula 1 is not a compound in which X is H, Y is CH3 and Z is OH.

## Claims

### Claim 1

A method of increasing the amount of melanin in melanocytes comprising a step of applying a composition comprising compound
to human skin or human hair,
wherein the composition additionally comprises a cosmetically acceptable base, and wherein the cosmetically acceptable base is an emulsion; and
wherein melanin is increased by 15 to 40% in the melanocytes.