# US 11,432,951 B2 · Tools for transurethral deployment and fixation of graft for the management and treatment of urethral strictures > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,432,951 B2 - Document ID: US11432951B2 - Status: Granted - Kind: B2 - Application number: 16/346,220 - Filed: 2017-10-31 - Published: 2020-02-13 - Granted: 2022-09-06 - Earliest claimed: 2016-10-31 - Assignees: The Johns Hopkins University - Applicants: The Johns Hopkins University - Inventors: Chanya Godzich Elakkad; Teja Maruvada; Joseph A. Pia; Shravya Srigiri; Kendall Covington; Edward James Wright - Web page: https://patentgrep.com/patent/US11432951B2 ## CPC - A61F 2/95: Instruments specially adapted for placement or removal of stents or stent-grafts - A61F 2/04: Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts (A61F2/18, A61F2/20 take precedence; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95) - A61F 2002/047: {Urethrae} - A61L 2400/10: Materials for lubricating medical devices - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract An embodiment in accordance with the present invention provides a device and method for the treatment of urethral stricture. The present invention places and holds a graft at an incised urethral stricture site for 5-21 days, while the graft adherences to the incised urethral stricture site. A device of the present invention includes a delivery component, a graft carrier component, and a removal component. In some embodiments, the delivery and removal components may be combined into the same device. The delivery component, the graft carrier component, and the removal component are all configured to enter and exit the urethra without trauma. A method according to an embodiment of the present invention includes harvesting a graft, loading the graft onto the graft carrier component, introducing the delivery device into the urethra with the graft carrier component and graft loaded, and delivering of the graft to the incised urethral stricture site. ## Claims ### Claim 1 A device, comprising: a membrane carrier component comprising at least two separate parts each configured to expand when placed at a urethral stricture site of a urethra, wherein the at least two separate parts comprise a first part and a second part, wherein the membrane carrier component expands by the first part and the second part moving away from each other on at least one side, wherein the first part is configured to hold a membrane for placement at the urethral stricture site, wherein the second part is configured to be in direct contact with the urethra and is associated with fixation of the membrane carrier component at the urethral stricture site, and wherein the membrane carrier component is configured to be fixated at the urethral stricture site by surface characteristics along a length of the second part; and a delivery component configured to secure at least one of the first part or the second part and deliver the membrane carrier component through the urethra to the urethral stricture site for the membrane to adhere to the urethral stricture site, wherein the first part and the second part move away from each other in a direction perpendicular to the delivery component during expansion. ### Claim 2 (depends on 1) The device of claim 1, wherein the at least two separate parts are positioned in at least one of: serial, serial offset, concentric, inscribed, nested, jointed, hinged, or interleaved. ### Claim 3 (depends on 1) The device of claim 1, wherein the at least two separate parts of the membrane carrier component comprise a locking mechanism for joining the at least two separate parts into a single part. ### Claim 4 (depends on 1) The device of claim 1, further comprising: platens to hold the membrane in place on the membrane carrier component. ### Claim 5 (depends on 1) The device of claim 1, further comprising: a fixation component for fixing the membrane carrier component at the urethral stricture site. ### Claim 6 (depends on 1) The device of claim 1, further comprising: an endoscope for insertion through a lumen of the delivery component to allow for illumination and visualization of the urethral stricture site during incision of the urethral stricture site. ### Claim 7 (depends on 1) The device of claim 1, further comprising: a tool for incising the urethral stricture site. ### Claim 8 (depends on 1) The device of claim 1, wherein the delivery component further comprises an elongate shaft, wherein the elongate shaft defines a lumen, and wherein the elongate shaft is configured to allow passage of the membrane carrier component. ### Claim 9 (depends on 1) The device of claim 1, further comprising: an inner sheath for insertion into a lumen of the delivery component. ### Claim 10 (depends on 1) The device of claim 1, further comprising: an external sheath defining a lumen configured to receive at least the delivery component. ### Claim 11 A method, comprising: securing a membrane to a first part of a carrier component, wherein the carrier component comprises at least two separate parts including the first part and a second part; coupling at least one of the first part or the second part to a delivery component; inserting, based on the coupling of at least one of the first part or the second part to the delivery component, the delivery component with the carrier component into a urethra; advancing, based on the inserting of the delivery component with the carrier component into the urethra, the carrier component to a stricture site; expanding the carrier component by the first part and the second part moving away from each other on at least one side, wherein the second part is in direct contact with the urethra and is associated with fixation of the carrier component at the stricture site, wherein the first part and the second part move away from each other in a direction perpendicular to the delivery component, and wherein the carrier component is fixated at the stricture site by surface characteristics along a length of the second part. ### Claim 12 (depends on 11) The method of claim 11, further comprising: locking the at least two separate parts of the carrier component together. ### Claim 13 (depends on 11) The method of claim 11, further comprising: inserting an incision tool through a lumen defined by the delivery component; and incising the stricture site. ### Claim 14 (depends on 11) The method of claim 11, further comprising: inserting an endoscope for illumination and visualization through a lumen defined by the delivery component. ### Claim 15 (depends on 11) The method of claim 11, further comprising: fixing the carrier component at the stricture site. ### Claim 16 (depends on 11) The method of claim 11, further comprising: passing a Foley catheter through a lumen defined by at least the carrier component. ### Claim 17 (depends on 11) The method of claim 11, further comprising: leaving the carrier component at the stricture site for approximately 5-21 days. ### Claim 18 (depends on 11) The method of claim 11, further comprising: removing the carrier component after membrane adherence at the stricture site. ### Claim 19 A device, comprising: a carrier component comprising at least two separate parts each configured to expand when placed at a site within a lumen, wherein the at least two separate parts comprise a first part and a second part, wherein the carrier component expands by the first part and the second part moving away from each other on at least one side, wherein the first part is configured to hold a membrane for placement at the lumen, wherein the second part is configured to be in direct contact with the lumen, and wherein the carrier component is configured to be fixated at the site within the lumen by surface characteristics along a length of the second part; and a delivery component configured to secure the at least one of the first part or the second part and deliver the carrier component through the lumen to the site within the lumen for treatment material contact at the site within the lumen, wherein the first part and the second part move away from each other in a direction perpendicular to the delivery component during expansion. ### Claim 20 (depends on 19) The device of claim 19, wherein the delivery component is structured for the carrier component to be coupled to a fixed location on the delivery component during delivery. ### Claim 21 (depends on 19) The device of claim 19, wherein the carrier component expands based on movement associated with at least a first end of the first part and at least a second end of the second part. ### Claim 22 (depends on 19) The device of claim 19, wherein the expansion of the first part and the second part is achieved by actuation of the delivery component. ### Claim 23 (depends on 22) The device of claim 22, wherein the delivery component comprises inter-leaved components. ### Claim 24 (depends on 19) The device of claim 19, wherein the second part comprises a fixation component, and wherein the carrier component is fixated at the site by the fixation component.