# US 11,432,867 B2 · Margin extension device and method

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- Number: US 11,432,867 B2
- Document ID: US11432867B2
- Status: Granted
- Kind: B2
- Application number: 16/531,557
- Filed: 2019-08-05
- Published: 2019-11-21
- Granted: 2022-09-06
- Earliest claimed: 2014-10-07
- Assignees: City of Hope
- Applicants: City of Hope
- Inventors: Gagandeep Singh; Jonathan Kessler
- Web page: https://patentgrep.com/patent/US11432867B2

## CPC

- A61B 18/1402: {Probes for open surgery}
- A61B 2018/00077: {high, i.e. electrically conducting}
- A61B 2018/00327: {Ear, nose or throat}
- A61B 2018/00488: {Esophagus}
- A61B 2018/00494: {Stomach, intestines or bowel}
- A61B 2018/005: {Rectum}
- A61B 2018/00541: {Lung or bronchi}
- A61B 2018/00559: {Female reproductive organs}
- A61B 2018/00577: {Ablation}
- A61B 2018/00613: {Irreversible electroporation}
- A61B 2018/143: {multiple needles}
- A61B 2018/1467: {using more than two electrodes on a single probe}
- A61N 1/327: {for enhancing the absorption properties of tissue, e.g. by electroporation}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

A margin extension device and method are disclosed herein. The margin extension device can be used for ablating one or several cancer cells and can include a contact member and a plurality of electrodes. The contact member can be electrically conductive, and can electrically connect the electrodes. The margin extension device can further include one or several leads that connect the electrodes of the margin extension device to a treatment controller. The treatment controller can include a pulse generator that can generate one or several electrical pulses that generate one or several electrical fields in tissue proximate to the margin extension device.

## Claims

### Claim 1

A surgical margin extender comprising:
an anode;
a cathode; and
a contact member, wherein the contact member comprises a conductive material, wherein the contact member electrically connects the anode and the cathode; and wherein the contact member electrically connects the anode and cathode at a distance such that the anode and the cathode can electroporate a cancer cell, wherein the contact member is a planar structure that forms a cylindrical insert by rolling a first end region of the contact member to overlap a second end region of the contact member.

### Claim 2 (depends on 1)

The margin extender of claim 1, wherein the anode comprises a first elongate member and wherein the cathode comprises a second elongate member.

### Claim 3 (depends on 2)

The margin extender of claim 2, wherein the first elongate member comprises a first needle having a first proximal end and a first distal end, and wherein the second elongate member comprises a second needle having a second proximal end and a second distal end.

### Claim 4 (depends on 2)

The margin extender of claim 2, wherein the first elongate member and the second elongate member are parallel when connected to the contact member.

### Claim 5 (depends on 4)

The margin extender of claim 4, wherein the first elongate member comprises a first voltage-delivery portion and a first insulative portion, and wherein the second elongate member comprises a second voltage-delivery portion and a second insulative portion.

### Claim 6 (depends on 5)

The margin extender of claim 5, wherein the first and second voltage-delivery portions of the first and second elongate members are at least partially connected to the contact member.

### Claim 7 (depends on 6)

The margin extender of claim 6, wherein the first and second voltage-delivery portions of the first and second elongate members are completely connected to the contact member.

### Claim 8 (depends on 6)

The margin extender of claim 6, wherein the contact member comprises a contact surface configured for connecting with a living tissue.

### Claim 9 (depends on 8)

The margin extender of claim 8, wherein the first and second voltage-delivery portions of the first and second elongate members extend from within the contact member to beyond the contact surface of the contact member.

### Claim 10 (depends on 1)

The margin extender of claim 1, wherein the contact member is flexible.

### Claim 11 (depends on 1)

The margin extender of claim 1, further comprising a handle extending from the contact member, wherein the handle is configured to allow gripping of the treatment device.

### Claim 12 (depends on 1)

The margin extender of claim 1, wherein the first end region forms a first edge of the contact member and the second end region forms a second, opposed edge of the contact member.

### Claim 13 (depends on 12)

The margin extender of claim 12, wherein the first end region and the second end region are in juxtaposed contact with one another.

### Claim 14

A treatment system comprising:
a control module, wherein the control module is configured to generate at least one electrical pulse configured to electroporate a cancer cell;
a surgical margin extender comprising:
an anode;
a cathode; and
a contact member electrically connecting the anode and cathode in a configuration such that the anode and the cathode can electroporate the cancer cell via the transmission of the at least one pulse to a living tissue, wherein the contact member is a planar structure that forms a cylindrical insert by rolling a first end region of the contact member to overlap a second end region of the contact member; and
leads connecting the anode and the cathode to the control module.

### Claim 15 (depends on 14)

The treatment system of claim 14, wherein the anode comprises a first elongate member and wherein the cathode comprises a second elongate member.

### Claim 16 (depends on 15)

The treatment system of claim 15, wherein the first elongate member and the second elongate member are parallel when connected to the contact member.

### Claim 17 (depends on 16)

The treatment system of claim 16, wherein the contact member comprises a contact surface configured for electrically connecting with a living tissue.

### Claim 18 (depends on 17)

The treatment system of claim 17, wherein the first and second elongate members are parallel with the contact surface.

### Claim 19 (depends on 17)

The treatment system of claim 17, wherein the first and second elongate members intersect the contact surface.

### Claim 20 (depends on 19)

The treatment system of claim 19, wherein the first and second elongate members extend from one side of the contact surface to the other side of the contact surface.

### Claim 21 (depends on 14)

The treatment system of claim 14, wherein the contact member is flexible.

### Claim 22 (depends on 14)

The treatment system of claim 14, further comprising a handle extending from the contact member, wherein the handle is configured to allow gripping of the treatment.

### Claim 23 (depends on 14)

The treatment system of claim 14, wherein the first end region forms a first edge of the contact member and the second end region forms a second, opposed edge of the contact member.

### Claim 24 (depends on 23)

The treatment system of claim 23, wherein the first end region and the second end region are in juxtaposed contact with one another.

### Claim 25

A method of treating a cancer, the method comprising:
identifying the location for providing a treatment;
applying a surgical margin extender to tissue at the treatment location, wherein the margin extender comprises:
an anode;
a cathode; and
a contact member, wherein the contact member comprises a conductive material that electrically connects the anode and the cathode; and wherein the contact member electrically connects the anode and cathode at a distance such that the anode and the cathode can electroporate the cancer cell;
rolling the contact member to form a cylindrical insert and inserting the cylindrical insert into a void defined by the tissue, wherein the contact member has a first end region and an opposed second end region, and wherein the first end region overlaps the second end region;
applying an electrical current to the contact member via the anode and cathode, wherein the application of the electrical current to the contact member via the anode and the cathode electroporates a cancer cell at the treatment location.

### Claim 26 (depends on 25)

The method of claim 25, wherein the tissue proximate to the cancer cell is located on an exterior portion of the body.

### Claim 27 (depends on 25)

The method of claim 25, wherein the tissue proximate to the cancer cell is located on an interior portion of the body.

### Claim 28 (depends on 27)

The method of claim 27, wherein the interior portion of the body is accessible via an existing orifice.

### Claim 29 (depends on 28)

The method of claim 28, wherein the interior portion of the body comprises at least one of:
a nasal passageway;
a mouth;
a throat;
an esophagus;
a trachea;
a vagina;
a rectum; and
a colon.