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US 11,428,691 B2Granted
Methods for predicting tumor response to immunotherapy
AssigneeDuke University
InventorsDavid Ashley, Darell Bigner, Matthias Gromeier, Smita Nair
Life of this patent
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Abstract
Methods of testing tumor samples for mutational burden and/or for expression profiles permit the prediction of responsiveness of an individual to immunotherapy comprising PVSRIPO. Those predicted to respond are treated with PVSRIPO and those predicted not to respond are treated with other agents.
Claims15
A method of treating an individual having a tumor, comprising:
- (a) testing a tumor sample from the individual and determining its tumor mutational burden;
- and
- (b) upon determining a low mutational burden in the tumor sample, administering to the individual an immunotherapeutic agent comprising PVSRIPO.
A method of treating a population of at least a first and a second individual, each individual having a tumor, comprising:
- testing a first tumor sample from the first individual and a second tumor sample from the second individual and determining tumor mutational burden in the first and second tumor sample, wherein (a) upon determining a high mutational burden in the first tumor sample, administering to the first individual a therapy that does not comprise PVSRIPO;
- and (b) upon determining a low mutational burden in the second tumor sample, administering to the second individual an immunotherapeutic agent comprising PVSRIPO.
Dependencies are inferred from the claim text.