Anti-Gal3 antibodies and uses thereof
AssigneeTrueBinding, Inc.
InventorsDongxu Sun, Yan Wang, Yinan Wu, Catherine A. Gordon, Samuel A. F. Williams
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Abstract
Disclosed herein are antibodies that specifically bind to Gal3 and methods of use thereof. In some embodiments, also described herein are methods of inducing immune activation or promoting T cell or Natural Killer cell proliferation with an antibody that specifically binds to Gal3. Also disclosed herein are methods and compositions of reducing fibrosis or propensity thereof in a tissue with antibodies that specifically bind to Gal3. In some cases, the anti-Gal3 antibody also disrupts the interaction between Gal3 and TIM-3.
Claims5
An anti-GAL3 antibody comprising:
- an HCDR1 comprising the sequence of SEQ ID NO:
- 62;
- an HCDR2 comprising the sequence of SEQ ID NO:
- 90;
- an HCDR3 comprising the sequence of SEQ ID NO:
- 118;
- an LCDR1 comprising the sequence of SEQ ID NO:
- 146;
- an LCDR2 comprising the sequence of SEQ ID NO:
- 174;
- and
- an LCDR3 comprising the sequence of SEQ ID NO:
- 202.
An anti-GAL3 antibody comprising:
- a heavy chain variable region comprising the sequence of SEQ ID NO:
- 230;
- and
- a light chain variable region comprising the sequence of SEQ ID NO:
- 258.
An anti-GAL3 antibody comprising:
- a heavy chain comprising the sequence of SEQ ID NO:
- 265;
- and
- a light chain comprising the sequence of SEQ ID NO:
- 266.
Dependencies are inferred from the claim text.